Table of contents:
- Functions & Usage
- What is Pamidronate used for?
- How do you use Pamidronate?
- How do I save Pamidronate?
- Precautions & Warnings
- What should be considered before using Pamidronate?
- Is Pamidronate safe for pregnant and lactating women?
- Side effects
- What are the possible side effects of Pamidronate?
- Drug Interactions
- What drugs can interfere with the drug Pamidronate?
- Can certain foods and drinks interfere with the drug Pamidronate?
- What health conditions can interfere with the performance of the drug Pamidronate?
- Dose
- What is the dose of Pamidronate for adults?
- What is the dosage of Pamidronate for children?
- In what dosages and preparations is Pamidronate available?
- What to do in an emergency or overdose?
- What should I do if I forget to take medicine or forget to take medicine?
Functions & Usage
What is Pamidronate used for?
Pamidronate is a drug to treat high blood calcium levels and certain bone problems (bone metastases / lesions) that may occur with some types of cancer. This medication is also used to treat a certain type of bone disease (Paget's disease) that causes abnormal and weak bones.
Pamidronate belongs to a class of drugs known as bisphosphonates. These drugs work by slowing the release of calcium from bones to lower blood calcium levels, reduce the risk of fractures (fractures) and reduce bone pain.
How do you use Pamidronate?
This medication is given by injection slowly into a vein for a minimum of 2 hours to 24 hours, or as directed by your doctor.
Dosage is based on your medical condition, laboratory tests, and response to treatment. Your doctor will order blood tests to check your kidney function before any treatment with this medicine. The maximum adult dose of this medicine is 90 milligrams for a single dose.
If you are giving this medication to yourself at home, learn all the preparation and directions for use from your healthcare professional. Before using it, check this product visually, if there are particles or a discoloration occurs, do not use medicinal liquid. Learn how to store and dispose of medical supplies safely.
If you are being treated for a condition with high blood calcium levels, you may only receive a single dose of pamidronate. If you are being treated for cancer-related bone problems, you may receive a dose every 3 to 4 weeks. If you are being treated for Paget's disease, you may receive medication every day for 3 days. Consult your doctor or pharmacist for more details.
During treatment with this medicine, it is important that you drink plenty of fluids and urinate frequently to help avoid kidney problems. Intravenous fluids are usually given with this medicine. Ask your doctor how much fluid you should drink and follow these directions carefully.
This drug can take up to 7 days to work optimally.
Tell your doctor if your condition does not improve or gets worse.
Follow the rules given by your doctor or pharmacist before starting treatment. If you have any questions, consult your doctor or pharmacist.
How do I save Pamidronate?
This medication is best stored at room temperature, away from direct light and damp places. Don't keep it in the bathroom. Don't freeze it. Other brands of this drug may have different storage rules. Observe the storage instructions on the product package or ask your pharmacist. Keep all medicines away from children and pets.
Do not flush medicines down the toilet or down the drain unless instructed to do so. Discard this product when it has expired or when it is no longer needed. Consult your pharmacist or local waste disposal company about how to safely dispose of your product.
Precautions & Warnings
What should be considered before using Pamidronate?
In deciding to use this drug, the risks of using the drug must be weighed against its benefits. This is up to you and your doctor. For this drug, the following should be considered:
Allergy
Tell your doctor if you have ever had an unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to food, coloring, preservatives, or animals. For non-prescription products, read the label or list of ingredients that make up the medicine on the package carefully.
Children
Appropriate studies have not been conducted regarding the relationship of age to the effects of pamidronate injection in the pediatric population. Safety and efficacy are unknown.
Parents
The precise studies carried out to date have not shown specific problems in the elderly that will limit the usefulness of pamidronate injection in the elderly. However, elderly patients are more likely to have age-related kidney, liver, or heart problems that may require caution and an adjustment in the dose for patients receiving pamidronate injection.
Is Pamidronate safe for pregnant and lactating women?
There are no adequate studies regarding the risks of using this drug in pregnant or breastfeeding women. Always consult your doctor to weigh the potential benefits and risks before using this medication. This drug is included in the risk of pregnancy category D according to the US Food and Drug Administration (FDA). (A = No risk, B = No risk in some studies, C = Possible risk, D = Positive evidence of risk, X = Contraindicated, N = Unknown)
Side effects
What are the possible side effects of Pamidronate?
Get emergency medical help if you have any of these signs of an allergic reaction: nausea, vomiting, sweating, hives, itching, difficulty breathing, swelling of your face, lips, tongue, or throat, or feel like you might pass out.
Call your doctor if you have any of the following serious side effects:
- High fever
- Severe joint, bone, or muscle pain
- New or unusual pain in the thigh or hip
- Urinating less than usual or not at all
- Swelling, rapid weight gain
- Pain or burning when urinating
- Seizures
- Eye pain, vision changes
- Pale skin, feeling dizzy or short of breath, fast heart rate, difficulty concentrating
- Confusion, uneven heart rate, extreme thirst, increased urination, discomfort in the legs, muscle weakness or weakness, or muscle twitching
Less serious side effects may include:
- Low fever
- Stomach pain, loss of appetite, nausea, vomiting
- Constipation
- Pain, redness, swelling or a hard, painful lump under the skin around the area of the IV needle
Not everyone experiences the following side effects. There may be some side effects not listed above. If you have concerns about certain side effects, consult your doctor or pharmacist.
Drug Interactions
What drugs can interfere with the drug Pamidronate?
Drug interactions can change the performance of your medications or increase the risk of serious side effects. Not all possible drug interactions are listed in this document. Keep a list of all the products you use (including prescription / non-prescription drugs and herbal products) and consult your doctor or pharmacist. Do not start, stop, or change the dose of any medication without your doctor's approval
Although certain drugs should not be used at the same time, in other cases two different drugs can be used together even if interactions are possible. In this case, your doctor may be able to change the dose or take other precautions that may be needed. Tell your health care professional if you are taking any other prescription or nonprescription drugs on the market.
Can certain foods and drinks interfere with the drug Pamidronate?
Certain drugs should not be used with meals or when eating certain foods because drug interactions can occur. Consuming alcohol or tobacco with certain drugs can also cause interactions to occur. Discuss your use of drugs with food, alcohol, or tobacco with your health care provider.
What health conditions can interfere with the performance of the drug Pamidronate?
The presence of other health problems in your body may affect the use of this drug. Tell your doctor if you have other health problems .:
- Anemia
- Dehydration
- Heart disease
- Kidney illness
- Leukopenia (low white blood cell count)
- Mineral imbalances (for example, low levels of calcium, magnesium, phosphorus, or potassium in the blood)
- Thrombocytopenia (low platelet count) - Use with caution. It might make things worse
- Cancer, history
- Gum or tooth problems
- Dental surgery
- Poor oral hygiene or
- Surgery (eg, dental surgery) -may increase the risk for severe jaw problems.
- Parathyroid disease (for example, hypoparathyroidism)
- Thyroid surgery, history - this condition can increase your risk of having hypocalcemia (low levels of calcium in the blood)
Dose
The information provided is not a substitute for a doctor's prescription. ALWAYS consult your doctor or pharmacist before starting treatment.
What is the dose of Pamidronate for adults?
Usual Adult Dose for Hypercalcemia in Malignancy
60-90 mg as a single dose, slow intravenous infusion more than once every 2-24 hours. A longer infusion (eg> 2 hours) can reduce the risk of renal toxicity, especially in patients with pre-existing renal insufficiency. If significant hypercalcemia persists or recurs, a second dose, the same as the first, may be considered. A gap of at least 7 days should be given between doses. The response to the next dose may be reduced. Patients with recurrent hypercalcemia may require an infusion of pamidronate every 2-3 weeks to maintain normal blood calcium levels.
Usual Adult Dose for Paget's Disease
30 mg intravenously as a 4 hour infusion on 3 consecutive days. Some patients have received more than one treatment with the same dose.
Usual Adult Dose for Osteolytic Bone Lesions in Multiple Myeloma
90 mg intravenously as an infusion over 4 hours given monthly for up to 9 months.
Usual Adult Dose for Osteolytic Bone Metastases in Breast Cancer
90 mg intravenously as a 2 hour infusion given every 3 to 4 weeks.
What is the dosage of Pamidronate for children?
More than> 1 year:
0.5-1 mg / kg intravenously infusion slowly over 24 hours once. If significant hypercalcemia persists or recurs, a second dose, the same as the first, may be considered. A gap of at least 7 days should be given between doses.
In what dosages and preparations is Pamidronate available?
Solution, intravenous, sodium:
Generic: 30 mg / 10 ml (10 ml); 90 mg / 10 ml (10 ml)
Solution, intravenously, as disodium
Generic: 30 mg / 10 ml (10 ml); 6 mg / mL (10 mL) 90 mg / 10 ml (10 ml)
Dissolved solutions, intravenously, as disodium:
Generic: 30 mg (1EA); 90 mg (1EA).
What to do in an emergency or overdose?
In case of an emergency or overdose, contact the local emergency services provider (118/119) or immediately to the nearest hospital emergency department.
Overdose symptoms may include:
- Fever
- Changes in the ability to taste food
- Sudden tightening of muscles
- Numbness or tingling around the mouth
What should I do if I forget to take medicine or forget to take medicine?
If you forget a dose of this medicine, take it as soon as possible. However, when it is nearing the time of the next dose, skip the missed dose and return to the usual dosing schedule. Don't double the dose.
Hello Health Group does not provide medical consultation, diagnosis or treatment.
