Ryzodeg: functions, dosage, side effects, how to use it

Uses

What is Ryzodeg?

Ryzodeg is a combination of two types of artificial insulin, namely insulin aspart and insulin degludec. Ryzodeg consists of 70 percent insulin degludec and 30 percent insulin aspart. That's why this insulin is also known as Ryzodeg 70/30. Its use can help maintain blood sugar levels in patients with diabetes, be it type one diabetes or type two diabetes. However, this insulin is not intended for use in patients with diabetic ketoacidosis.

The aspart insulin contained in Ryzodeg is fast-acting insulin which can work really fast. Meanwhile, insulin degludec is long-acting insulin which has a longer service life in the body. The combination of these two insulin starts to work within 10 - 20 minutes after injection and reaches a peak working period within one hour. Ryzodeg can also work for 24 hours or even more.

Combined insulin, such as Ryzodeg, is also called premix insulin.

How do I use Ryzodeg?

Use this medication as instructed by your doctor. Follow all directions on the label. Do not use this medication in doses lower or smaller than prescribed or use Ryzodeg for longer than recommended.

Ryzodeg is insulin which is used by injection in the subcutaneous tissue or subcutaneous tissue. This insulin can be injected into the area of ​​the thigh, upper arm, or abdomen. Do not make the injection at the same point twice in succession. This will increase the risk of problems in the subcutaneous tissue, such as thickening of the fat tissue which can be seen from the appearance of the lump. This condition is called lipodystrophy.

This insulin is usually given once or twice a day at the same time as the main meal. You may be able to use fast acting insulin otherwise, on your other main meal schedule, if your doctor instructs you to. Follow the dosage that your doctor gives you very carefully. Do not mix other insulin with Ryzodeg. Use a different injection device to inject two different insulin.

Do not use this insulin if the liquid has changed color or looks cloudy. Contact your doctor or pharmacist for new medicines.

Do not share the injection pen with others even after the needle has been changed. This will increase the risk of passing the disease or infection from one person to another.

How to save Ryzodeg?

Store Ryzodeg in its original container and keep it away from heat and light. You can store the Ryzodeg in the refrigerator at a temperature of 2 - 8 degrees Celsius. Do not freeze the Ryzodeg or store it near the cooling element in the refrigerator. Discard frozen Ryzodeg and do not use it even though it is liquid again.

Stores unopened Ryzodeg

Store unopened Ryzodeg in the refrigerator and use it before expiration.

Save an already opened Ryzodeg

Store the injection pen at room temperature no more than 30 degrees Celsius. Do not store it in the refrigerator and use it within 28 days. Discard this medicine that has been more than 28 days even if there is still some medicine left. Do not store this insulin injection pen with the needle still attached.

Dose

The information provided is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist before starting treatment.

What is the dosage of Ryzodeg for adults?

Patients with type 1 diabetes

• Initial dose for patients who have not used insulin: ⅓ to ½ of the daily total insulin requirement, once daily. The daily total insulin requirement for insulin-naive patients is usually 0.2 - 0.4 units per kilogram of body weight
• Switch from insulin premix with a dose of one or two times a day: equate the initial dose with the dose used insulin premix
• Switch from basal insulin once or twice a day: equate the starting dose with the one-time daily basal insulin dose at the same time as the main meal schedule. Basal insulin is insulin which is given at bedtime or when the patient is no longer eating / fasting

Patients with type 2 diabetes

• Initial dose: 10 units, once a day
• Switch from insulin premix with a dose of one or two times a day: equate the initial dose with the dose used insulin premix
• Switch from basal insulin once or twice a day: equate the starting dose with the one-time daily basal insulin dose at the same time as the main meal schedule.

Dosage adjustments or increases can be done every 3-4 days

What is the dosage of Ryzodeg for children?

Safety and effectiveness for children have not been established.

In what dosages and preparations is Ryzodeg available?

Injection, Subcutaneous: 100 units / mL: 3 mL FlexTouch injection pen

Side effects

What side effects might occur due to using Ryzodeg?

Get emergency medical help right away if you notice symptoms of an allergic reaction to Ryzodeg, which is characterized by itching, rash, sneezing, fatigue, difficulty breathing, feeling like falling, nausea, diarrhea, swelling of the face / lips / tongue / throat.

Call your doctor immediately, if you experience:

• Fluid buildup, which is characterized by weight gain, swelling of the hands and feet, a feeling of shortness of breath
• Lack of potassium, characterized by cramps in the legs, constipation, irregular heartbeat, palpitations, excessive thirst, frequent urination, tingling or numbness, weakness, and a feeling of weakness

Some of the common side effects of Ryzodeg include:

• Low blood sugar levels
• Itching, rash on the skin
• Thickening of the area of ​​the skin at the point of injection

Remember that your doctor prescribes certain medications because they judge their benefits to outweigh the risk of possible side effects. Almost all drugs have side effects, but in most cases, they rarely require serious attention.

The above list is not a complete list of the side effects that occur. There may be other side effects not mentioned above. Talk to your doctor about any side effects you fear will occur.

Warnings and Precautions

What should I pay attention to before using Ryzodeg?

• Tell your doctor if you have an allergy to insulin aspart or insulin degludec or you are experiencing hypoglycemia
• Inform all of your complete medical history, both previous and current illnesses. To make sure this insulin is safe, tell your doctor if you have kidney or liver disease, hypokalemia or low levels of potassium in the blood, and diabetes ketoacidosis.
• You may experience visual disturbances, weakness, and drowsiness due to drastic changes in blood sugar levels. Do not do activities that require high alertness, such as driving, after the injection before knowing how your body is responding
• Tell your doctor if you are taking pioglitazone or rosiglitazone (sometimes mixed in drugs combined with glimepiride or metformin). Taking certain oral diabetes medications along with Ryzodeg can increase your risk of serious heart disease
• Tell your doctor if you are planning or are pregnant. The use of diabetes drugs during pregnancy is only permitted if the benefits outweigh the risks that may befall the fetus. Consult your doctor regarding the use of this drug while pregnant and breastfeeding. Your doctor may provide other diabetes treatment alternatives during pregnancy

Is Ryzodeg safe to use for pregnant and lactating women?

Studies conducted on animals have shown side effects in the fetus. However, there have not been controlled studies in women or breastfeeding mothers regarding the use of Ryzodeg. Consult with your doctor regarding the administration of this drug. This medicine should only be given if the benefits outweigh the risks to the fetus.

According to the United States Food and Drug Administration (FDA), this drug is known to fall into a category C pregnancy risk (possibly risky).

This drug is also known to flow out along with breast milk in animal studies. However, it is not known whether this combination of insulin is also excreted through breast milk in humans. Consult your doctor regarding the use of Ryzodeg while breastfeeding.

Interaction

What medicines interact with Ryzodeg?

Certain drugs cannot be taken at the same time because they can cause drug interactions. Drug interactions can cause the drugs you are taking to not work properly or increase the risk of side effects. Even so, sometimes doctors prescribe both drugs at the same time if needed. In that case, the doctor will make dosage adjustments and provide directions to you about the instructions for taking the drug.

The following is a list of products that may interact with Ryzodeg:

• Prandin (repaglinide)
• Rosuvastatin
• Saxenda (liraglutide)

The list above is not an exhaustive list of the products that may interact. Tell your doctor if you use the above products and all the products you consume, including prescription or nonprescription, vitamins, and herbal medicines.

What health conditions interact with Ryzodeg?

• Kidney / liver disease
• Hypokalemia (potassium deficiency)
• Hypoglycemia

Overdose

What should I do in an emergency or Ryzodeg overdose?

Call emergency medical assistance immediately (119) or immediately to the nearest hospital emergency department if you notice signs of hypoglycemia. Insulin overdose can cause hypoglycemia which is quite dangerous. Symptoms can include intense drowsiness, confusion, blurred vision, numbness or tingling in the mouth, difficulty speaking, muscle weakness, clumsiness, seizures, or loss of consciousness.

What if I forget the Ryzodeg injection schedule?

Ignore the missed schedule and return to using this insulin at the same time as your next big meal. After that continue this insulin injection on your regular schedule. Do not double up on a dose to make up for a missed dose. Always provide Ryzodeg wherever you are. Refill them before your supplies are completely depleted.