Table of contents:
- What Drug Vasopressin?
- What is vasopressin for?
- How is vasopressin used?
- How is vasopressin stored?
- Vasopressin dosage
- What is the vasopressin dosage for adults?
- What is the vasopressin dosage for children?
- In what dosage is vasopressin available?
- Vasopressin side effects
- What side effects can be experienced due to vasopressin?
- Vasopressin Drug Warnings and Cautions
- What should be known before using vasopressin?
- Is vasopressin safe for pregnant and lactating women?
- Vasopressin Drug Interactions
- What medicines might interact with vasopressin?
- Can food or alcohol interact with vasopressin?
- What health conditions can interact with vasopressin?
- Vasopressin overdose
- What should I do in an emergency or overdose?
- What should I do if I miss a dose?
What Drug Vasopressin?
What is vasopressin for?
Vasopressin is a hormone made by the human body called "anti-diuretic hormone" which is normally secreted by the pituitary gland. Vasopressin acts on the kidneys and blood vessels.
Vasopressin prevents loss of fluid from the body by reducing urine output and helping the kidneys absorb water into the body. Vasopressin also increases blood pressure by constricting blood vessels.
Vasopressin is used to treat diabetes insipidus, which is caused by a lack of this natural pituitary hormone in the body. Vasopressin is also used to treat or prevent certain stomach conditions after surgery or during abdominal x-rays.
Vasopressin is also used for other purposes that are not on the list of instructions for this drug.
How is vasopressin used?
Vasopressin is injected into a muscle or under the skin. A health care worker will inject it into you.
Vasopressin is usually given as needed every 3-4 hours. The time interval between doses depends on how your body responds to the drug.
To treat diabetes insipidus, vasopressin is sometimes given to the nose using a nasal spray or medicated dropper, or by inserting a cotton ball soaked with vasopressin.
When used for abdominal x-rays, vasopressin injection is usually given 2 hours before and 30 minutes before the x-ray. Doctors also recommend that you receive an enema before you receive your first dose of vasopressin.
Vasopressin can cause temporary side effects such as nausea, stomach pain, or "pale" skin (such as a pale spot when you press on the skin).
Drinking 1 or 2 glasses of water each time you receive your injection can help alleviate this side effect.
While using vasopressin, you may need frequent blood tests. Heart function can also be checked using electrocardiography or an EKG.
Follow your doctor's instructions regarding the amount of fluids you should drink during therapy with vasopressin. In some cases, drinking too much can be no safer than not drinking enough.
Follow the rules given by your doctor or pharmacist before starting treatment. If you have any questions, consult your doctor or pharmacist.
How is vasopressin stored?
This medication is best stored at room temperature, away from direct light and damp places. Don't keep it in the bathroom. Don't freeze it. Other brands of this drug may have different storage rules. Observe the storage instructions on the product package or ask your pharmacist. Keep all medicines away from children and pets.
Do not flush medicines down the toilet or down the drain unless instructed to do so. Discard this product when it has expired or when it is no longer needed. Consult your pharmacist or local waste disposal company about how to safely dispose of your product.
Vasopressin dosage
The information provided is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist before starting treatment.
What is the vasopressin dosage for adults?
Adult Dose for Diabetes Insipidus:
5 units to 10 units intramuscular or subcutaneous 2-4 times a day.
Continuous IV infusion: 0.0005 units / kg / hour; repeat doses as needed every 30 minutes to a maximum of 0.01 units / kg / hour.
Vasopressin can also be given in the nose with a cotton tampon, by nasal spray, or by dropping. When vasopressin is administered intranasally by spray or tampon, the dose should be titrated for each patient.
Adult Dose for Postoperative Pain Relief:
5 intramuscular units once.
This dose can be doubled and repeated at 3-4 hour intervals as needed to prevent or relieve abdominal distension after surgery.
This recommendation is also used for distension due to pneumonia or other acute toxemia.
Adult Dose for Abdominal Distention before abdominal X-ray:
10 intramuscular units once 2 hours before the X-ray and again 30 minutes before the X-ray.
Adult Dose for Gastrointestinal Bleeding:
0.2-0.4 units / minute by continuous intravenous infusion. Then titrate the dose as needed (maximum dose: 0.8 units / minute); if bleeding continues, continue with the same dose for 12 hours, then decrease the dose for 24-48 hours.
What is the vasopressin dosage for children?
Children's Dose for Diabetes Insipidus:
2.5 units to 10 units intramuscularly at a time.
This dose can be repeated 2-3 times a day as needed.
Alternatively, a vasopressin infusion of 0.0005 units / kg / hour can be given and titrated to reduce urine output and maintain a more concentrated urine.
Child dosage for esophageal varices with bleeding:
Continuous IV infusion:
Initial: 0.002-0.005 units / kg / minute; dose titration as needed; maximum dose: 0.01 unit / kg / minute.
Alternative: Initial: 0.1 units / minute; increased by 0.05 units / minute to maximum:
Less than 5 years: 0.2 units / minute
5-12 years: 0.3 units / minute
Over 12 years: 0.4 units / minute
If bleeding stops within 12 hours, reduce the dose for 24-48 hours.
Children's Dose for Asystole:
Limited data are available: 0.4 unit / kg IV after traditional resuscitation methods and at least 2 doses of epinephrine have been given .; Note: because the evidence is insufficient, there is neither an official recommendation nor an official prohibition on the use of vasopressin during pediatric cardiac arrest.
Children's Dose for Ventricular Fibrillation:
Limited data are available: 0.4 unit / kg IV after traditional resuscitation methods and at least 2 doses of epinephrine have been given; Note: because the evidence is insufficient, there is neither an official recommendation nor an official prohibition on the use of vasopressin in childhood cardiac arrest.
In what dosage is vasopressin available?
Vasopressin is available in the following dosages.
Injection of 20 units / mL
Vasopressin side effects
What side effects can be experienced due to vasopressin?
Some people receiving vasopressin experience an immediate drug reaction. Tell your doctor right away if you feel faint, nauseous, floating, sweating, or have a fast heartbeat, shortness of breath, or shallow breathing after receiving vasopressin.
Seek immediate medical help if you experience any of the following signs of an allergic reaction: hives, difficulty breathing, swelling of the face, lips, tongue, or throat.
Tell your doctor if you experience the following serious side effects:
- Heart rate slow or not felt
- Shortness of breath or shortness of breath
- Chest pain or feeling heavy, pain radiating to the arm or shoulder, nausea, sweating, feeling unwell
- Tingling or numbness in the hands or feet
- The skin changes color
- Swelling, weight gain quickly
- Feels like floating, passed out
- Nausea or severe stomach pain
Less common side effects are:
- Mild stomach pain, bloating
- Dizzy
- Throbbing headache
Not everyone experiences the following side effects. There may be some side effects not listed above. If you have concerns about certain side effects, consult your doctor or pharmacist.
Vasopressin Drug Warnings and Cautions
What should be known before using vasopressin?
In using this drug, the risks of using the drug must be weighed against the benefits obtained. The decision is made by both the doctor and you. For this drug, the following should be considered:
Allergy
Tell your doctor if you have had an allergic reaction to this or any other medicine. And also let me know if you have allergies to anything else, such as food, coloring, preservatives, or animals. For non-prescription products, read the ingredients in the packaging carefully.
Children
Studies have not shown an association of age to the effect of Vasostrict ™ in children with vasodilatory shock. Its safety and efficacy are unknown.
Research has not shown specific pediatric problems, so the benefits of Pitressin® are still limited to children with diabetes insipidus and abdominal distension.
Elderly
Studies have not shown an association of age to the effects of thymolol in the elderly population, no elderly problems have been recorded. However, the elderly are more prone to developing liver, kidney or heart problems due to age, which may require an adjustment in the dose in patients receiving Vasostrict ™.
There is no information available that shows the relationship of age to the effects of Pitressin® in elderly patients.
Is vasopressin safe for pregnant and lactating women?
There are no adequate studies regarding the risks of using this drug in pregnant or nursing women. Always consult your doctor to weigh the potential benefits and risks before using this medication. This drug is included in the risk of pregnancy category C according to the US Food and Drug Administration (FDA).
The following references the pregnancy risk categories according to the FDA:
- A = No risk,
- B = not at risk in several studies,
- C = May be risky,
- D = There is positive evidence of risk,
- X = Contraindicated,
- N = Unknown
There is not yet sufficient information about the safety of using this medicine during pregnancy and breastfeeding. Always consult your doctor to weigh the potential benefits and risks before using this medication.
Vasopressin Drug Interactions
What medicines might interact with vasopressin?
Drug interactions can change the performance of your medications or increase the risk of serious side effects. Not all possible drug interactions are listed in this document. Keep a list of all the products you use (including prescription / non-prescription drugs and herbal products) and consult your doctor or pharmacist. Do not start, stop, or change the dose of any medication without your doctor's approval.
Although certain drugs cannot be used together, in other cases 2 different drugs can be used simultaneously although drug interactions may occur. In this case, the doctor can change the dose, or other warnings may be needed. Tell your doctor if you are taking any other prescription or nonprescription drugs.
Using this medicine with any of the following medicines is not recommended, your doctor may not treat you with this medicine or change the medicine you are taking.
- Bepridil
- Cisapride
- Levomethadyl
- Mesoridazine
- Pimozide
- Terfenadine
- Thioridazine
- Ziprasidone
Using this drug with other drugs is usually not recommended, but may be needed in some cases. If the two drugs are prescribed together, your doctor may have changed the dose or frequency of use of one or both drugs.
- Acecainide
- Ajmaline
- Amiodarone
- Amitriptyline
- Amoxapine
- Aprindine
- Arsenic Trioxide
- Astemizole
- Azimilide
- Bretylium
- Chloral Hydrate
- Chloroquine
- Chlorpromazine
- Clomipramine
- Desipramine
- Dibenzepin
- Disopyramide
- Dofetilide
- Dothiepin
- Doxepin
- Droperidol
- Encainide
- Enflurane
- Erythromycin
- Flecainide
- Fluconazole
- Fluoxetine
- Foscarnet
- Furosemide
- Gemifloxacin
- Halofantrine
- Halothane
- Hydroquinidine
- Ibutilide
- Imipramine
- Indomethacin
- Isoflurane
- Isradipine
- Lidoflazine
- Lorcainide
- Mefloquine
- Nortriptyline
- Octreotide
- Pentamidine
- Pirmenol
- Prajmaline
- Probucol
- Procainamide
- Prochlorperazine
- Propafenone
- Protriptyline
- Quinidine
- Sematilide
- Sotalol
- Spiramycin
- Sulfamethoxazole
- Tedisamil
- Telithromycin
- Trifluoperazine
- Trimethoprim
- Trimipramine
- Venlafaxine
- Zolmitriptan
Can food or alcohol interact with vasopressin?
Certain drugs should not be used with meals or when eating certain foods because drug interactions can occur. Consuming alcohol or tobacco with certain drugs can also cause interactions to occur. Discuss your use of drugs with food, alcohol, or tobacco with your health care provider.
What health conditions can interact with vasopressin?
The presence of other health problems in your body may affect the use of this drug. Tell your doctor if you have other health problems, in particular:
- Coronary heart disease (hardened arteries)
- Heart disease
- Kidney illness
- Asthma
- Migraine
- Epilepsy or other seizure disease
Vasopressin overdose
What should I do in an emergency or overdose?
In case of an emergency or overdose, contact the local emergency services provider (112) or immediately to the nearest hospital emergency department.
What should I do if I miss a dose?
If you forget a dose of this medicine, take it as soon as possible. However, when it is nearing the time of the next dose, skip the missed dose and return to the usual dosing schedule. Don't double the dose.
Hello Health Group does not provide medical advice, diagnosis or treatment.
