Table of contents:
- What drug Phenylbutazone?
- What is Phenylbutazone for?
- How is Phenylbutazone used?
- How is Phenylbutazone stored?
- Phenylbutazone dosage
- What is the Phenylbutazone dosage for adults?
- What is the dosage of Phenylbutazone for children?
- In what dosage is Phenylbutazone available?
- Phenylbutazone side effects
- What side effects can be experienced due to Phenylbutazone?
- Phenylbutazone Drug Warnings and Cautions
- What should be known before using Phenylbutazone?
- Is Phenylbutazone safe for pregnant and lactating women?
- Phenylbutazone Drug Interactions
- What medicines may interact with Phenylbutazone?
- Can food or alcohol interact with Phenylbutazone?
- What health conditions may interact with Phenylbutazone?
- Phenylbutazone overdose
- What should I do in an emergency or overdose?
- What should I do if I miss a dose?
What drug Phenylbutazone?
What is Phenylbutazone for?
Phenylbutazone is a drug that can help to reduce pain and inflammation caused by ankylosing spondylitis when other medications may not be suitable.
Ankylosing spondylitis is an inflammation that causes joint disease that affects the spine.
How is Phenylbutazone used?
Always use Phenylbutazone tablets exactly as directed by your doctor and always read the label. Your doctor will determine the right dose according to your condition. Ask your doctor or pharmacist if you are unsure.
- Take the tablets with food or immediately after eating.
- Swallow the tablet completely with plenty of water. Your doctor may ask you to take an antacid (medication for indigestion) at the same time.
- Drinking alcohol while taking Phenylbutazone can cause more alcohol effects than usual.
Follow the rules given by your doctor or pharmacist before starting treatment. If you have any questions, consult your doctor or pharmacist.
How is Phenylbutazone stored?
This medication is best stored at room temperature, away from direct light and damp places. Don't keep it in the bathroom. Don't freeze it. Other brands of this drug may have different storage rules. Observe the storage instructions on the product package or ask your pharmacist. Keep all medicines away from children and pets.
Do not flush medicines down the toilet or down the drain unless instructed to do so. Discard this product when it has expired or when it is no longer needed. Consult your pharmacist or local waste disposal company about how to safely dispose of your product.
Phenylbutazone dosage
The information provided is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist before starting treatment.
What is the Phenylbutazone dosage for adults?
The usual starting dose for the first 48 hours is 400 mg to 600 mg daily in divided doses.
The doctor will then reduce the dose to the minimum required amount, usually 200 mg to 300 mg daily in divided doses.
Elderly patients have a higher risk of side effects and should use the lowest effective dose for the shortest possible time, with additional monitoring performed by your doctor.
What is the dosage of Phenylbutazone for children?
This medicine is not suitable for children under 14 years of age.
In what dosage is Phenylbutazone available?
Tablets: 100 mg; 200 mg
Phenylbutazone side effects
What side effects can be experienced due to Phenylbutazone?
Call your doctor if you have any of the following serious side effects:
- ringing in the ears (tinnitus)
- dizziness (vertigo)
- depression
- hallucinations
- mental confusion
- dizziness, drowsiness, feeling lethargic and tired
- a feeling of numbness, tingling, or burning in the hands or feet
- asthma or asthma that is worse than usual (shortness of breath)
- swelling of the hands, feet (around the ankles) or stomach
- mouth pain (pain or ulcers on the tongue, cheeks, lips, throat or gums)
- swelling of the salivary glands (in front of the ear, under the lower jaw and under the tongue) that can make chewing or swallowing painful, dry mouth
- there is a lump in front of the neck, feeling tired and sensitive to cold, gaining weight
- constipation. This may be due to a change in the reaction of the thyroid gland
- reaction to the sun. Your skin may become red, painful, and swollen. Do not sunbathe, use tanning bed, or expose your skin to artificial UV rays
- deafness
- constipation or bloating
- difficulty swallowing
- blurred vision, bleeding in the eye
- feeling sick (malaise)
Not everyone experiences the following side effects. There may be some side effects not listed above. If you have concerns about certain side effects, consult your doctor or pharmacist.
Phenylbutazone Drug Warnings and Cautions
What should be known before using Phenylbutazone?
Do not use phenylbutazone if you:
- allergies to phenylbutazone or other anti-inflammatory drugs (such as aspirin, buprofen, cielecoxib), or one of the other ingredients (see Section 6)
- have, or have had, a stomach or intestinal condition such as an ulcer, bleeding in the stomach, large intestine or small intestine, or severe gastritis, especially if you have ever taken NSAIDs
- have inflammatory bowel disease (eg ulcerative colitis, Crohn's disease), because phenylbutazone can make this condition worse
- have severe heart, liver or kidney problems
- lung problems, swelling or high blood pressure that can affect the heart
- have thyroid gland disease
- have or have had a bleeding disorder, or another disorder that affects the blood or cells in your blood
- have Sjogren's syndrome, which is a disorder in which the mouth and eyes become very dry
- asthma. It should be noted that NSAIDs cause asthma attacks, rashes, swelling or inflammation of the nasal passages
- using other non-steroidal anti-inflammatory drugs (NSAIDs), (eg ibuprofen, diclofenac)
- pregnant more than 6 months
If you experience any of the above factors, talk to your doctor or pharmacist.
Is Phenylbutazone safe for pregnant and lactating women?
There are no adequate studies regarding the risks of using this drug in pregnant or nursing women. Avoid use unless you have been diagnosed with a pancreatic problem that requires you to take treatment with Phenylbutazone.
Phenylbutazone Drug Interactions
What medicines may interact with Phenylbutazone?
Drug interactions can change the performance of your medications or increase the risk of serious side effects. Not all possible drug interactions are listed in this document. Keep a list of all the products you use (including prescription / non-prescription drugs and herbal products) and consult your doctor or pharmacist. Do not start, stop, or change the dose of any medication without your doctor's approval
Please tell your doctor or pharmacist if you are taking or have recently used any other medicines, including over-the-counter medicines and herbal medicines.
Some medications may be affected by Phenylbutazone or can affect how well Phenylbutazone will work. Tell your doctor or pharmacist if you are also taking:
- medicines that can increase the occurrence of ulcers or bleeding in the stomach or intestines, such as:
- Corticosteroids are used to treat arthritis and inflammation
- Medicines such as anti-platelet agents, which are used to thin the blood (eg warfarin, aspirin, clopidogrel). Your doctor can check your blood for a short time
- Antidepressants called selective serotonin re-uptake inhibitors (SSRIs), (eg
paroxetine)
- Other anti-inflammatory drugs (eg diclofenac, celecoxib)
- medicines used for high blood pressure (eg atenolol, ramipril, valsartan)
- diuretics (water tablets) or heart medicines (eg digoxin, sotalol, diltiazem)
- some diabetes medications (eg glipizide, glibenclamide) or insulin
- drugs that suppress the immune system (eg cyclosporine, tacrolimus, methotrexate)
- lithium, a drug used to treat mood swings and some types of depression
- a drug that is usually prescribed through the hospital, called mifepristone (taken within the last 12 days)
- quinolone antibiotics (antibiotics used to treat infections)
- methylphenidate, a drug used to treat hyperactive conditions
- anabolic steroids, such as nandrolone
- Misoprostol, a drug used to treat ulcers in the stomach and intestines
- AZT, a drug used for HIV (human immunodeficiency virus)
- alcohol
- a drug used to treat epilepsy known as phenytoin
- medicines that affect liver enzymes - (check with your pharmacist). These drugs include barbiturates, chorphenamine, promethazine, rifampin, cholestyramine, and drugs used to control cholesterol.
Can food or alcohol interact with Phenylbutazone?
Certain drugs should not be used with meals or when eating certain foods because drug interactions can occur. Consuming alcohol or tobacco with certain drugs can also cause interactions to occur. Discuss your use of drugs with food, alcohol, or tobacco with your health care provider.
What health conditions may interact with Phenylbutazone?
The presence of other health problems in your body may affect the use of this drug. Tell your doctor if you have other health problems.
Phenylbutazone overdose
What should I do in an emergency or overdose?
In case of an emergency or overdose, contact the local emergency services provider (112) or immediately to the nearest hospital emergency department.
What should I do if I miss a dose?
If you forget a dose of this medicine, take it as soon as possible. However, when it is nearing the time of the next dose, skip the missed dose and return to the usual dosing schedule. Don't double the dose.
