Kombiglyze XR: functions, dosage, side effects, how to use

Uses

What is Kombiglyze XR?

Kombiglyze XR is a drug that is used in conjunction with a diet and exercise program to control blood sugar levels in patients with type two diabetes. Kombiglyze XR is an oral drug that contains two main ingredients, namely saxagliptin and metformin HCl. extended release (XR). Kombiglyze XR is not used for treatment in patients with type one diabetes.

The saxagliptin in Kombiglyze XR works by increasing the body's natural hormone called incretin. Incretins help control blood sugar by encouraging the release of insulin, especially after a meal. Meanwhile, the metformin in Kombiglyze XR plays a role in helping restore the body's response to insulin. These two drug combinations also decrease sugar production by the liver and decrease the absorption of sugar by the intestines during the digestion of food.

What are the rules for drinking Kombiglyze XR?

Kombiglyze XR is an oral medication that is usually taken once a day at the same time as dinner. Swallow this medication whole and do not split, crush, or chew this medication. Kombiglyze XR contains tablets extended release which will make the drug last longer in the body. Chewing it will make the resistance of the drug in the body faster and increase side effects.

Follow your doctor's instructions carefully when taking this medication. Make sure you increase your fluid intake, through drinking, when taking this medicine unless your doctor instructs you otherwise.

Your doctor may give you a low, low dose first at the start of treatment and will increase it gradually depending on your body's response. Do not change your dose or stop taking this drug before consulting your doctor. The dosage given is based on your health condition and your body's response to treatment.

How do I save Kombiglyze XR?

This medication is best stored at room temperature, no more than 30 degrees Celsius. Keep away from heat and direct light exposure. Avoid storing this medicine in a damp place such as in the bathroom. Keep out of reach of children and pets.

Do not flush or flush this medication down the toilet or drain unless instructed to do so. Discard this product if it has expired or is no longer needed. Ask your pharmacist or local waste disposal company about how to safely dispose of this product.

Dose

The information provided is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist before starting treatment.

What is the dosage for Kombiglyze XR for adult patients?

• Recommended starting dose for Kombiglyze XR patients who need 5 mg of saxagliptin and have not received treatment with metformin: 5 mg saxagliptin / 500 mg metformin extended release, once a day. The dose may be increased gradually to increase gastrointestinal side effects due to metformin consumption.
• For patients who have received treatment with metformin, the dose used is Kombiglyze XR with the same dose of metformin that is being consumed or the closest.
• For patients who need 2.5 mg of saxagliptin with a combination of metformin XR can use Kombiglyze XR 2.5 mg / 1,000 mg
• Patients who need 2.5 mg of saxagliptin, but have not used metformin or even need a metformin dose that is higher than 1,000 mg should be adjusted to the needs of these patients.
• Maximum dose: saxagliptin 5 mg - metformin XR 2,000 mg per day

What is the dosage of Kombiglyze XR for children?

The dosage in pediatric patients has not been established. This medicine may not be safe for your child. It is always important to understand the safety of drugs before using them. Please consult a doctor or pharmacist for more information.

In what dosage and dosage is Kombiglyze XR available?

Tablet, Oral: 5 mg / 500 mg; 5 mg / 1,000 mg; 2.5 mg / 1,000 mg

Side effects

What side effects may occur due to consumption of Kombiglyze XR?

Call your doctor immediately when you notice allergy symptoms after taking Kombiglyze XR, such as itching, peeling skin, shortness of breath, swelling of the face, eyes, lips, tongue, or throat.

The use of too much metformin in some people will lead to lactic acidosis. This has a fatal impact. Stop treatment and contact your doctor if you experience any of the following conditions:

• Unusual muscle pain
• Feeling cold
• Difficulty breathing
• Dizziness, lightheadedness, fatigue, or unusual weakness
• Abdominal pain, nausea and vomiting
• Irregular heartbeat

Tell your doctor right away if you notice any of the following serious side effects:

• A severe autoimmune reaction, characterized by itching, blisters, damage to the outer layer of skin
• Pain that doesn't go away in the joints
• Symptoms of heart failure, such as shortness of breath even when lying down, swelling in the legs, or rapid weight gain

Common side effects of taking Kombiglyze XR include:

• Diarrhea
• Headache
• Flu symptoms, such as runny / stuffy nose, sneezing, sore throat

Because Kombiglyze XR is a drug that affects blood sugar levels, hypoglycemia or hyperglycemia may also occur. Recognize the signs of both, such as blurred vision, body shaking, difficulty speaking, weakness for hypoglycemia and symptoms of hyperglycemia characterized by excessive thirst, frequent urination, confusion, drowsiness, rapid breathing, and fruity breath. .

The list above does not include the entire list of side effects that may occur due to consumption of Kombiglyze XR. Talk to your doctor about any possible side effects that you fear might occur.

Warnings and Precautions

What should I pay attention to when taking Kombiglyze XR?

Before taking this drug, make sure that you have informed your history of any drug allergies you have, including allergies to saxagliptin and metformin, as well as other drugs.

Your medical history also needs to be known by the doctor who treats you, including any diseases that you have or are currently suffering from, especially if you have a history of kidney disease, respiratory problems (lung disease or severe asthma), blood problems, such as anemia, illness. liver, pancreatitis, and other conditions that increase the risk of developing pancreatitis, such as gallstones, high triglycerides, and alcohol consumption).

Here are a few things you need to pay attention to before using Kombiglyze XR:

• Tell your doctor if you need to have a CT scan or MRI procedure that uses contrast fluid. You may need to stop using Kombiglyze XR for a moment before starting this procedure.
• Limit alcohol consumption when using this medicine as it can increase the risk of developing lactic acidosis, pancreatitis, and hypoglycemia.
• This medicine may cause blurred vision, dizziness, or severe drowsiness due to the extreme drop in blood sugar levels. Avoid activities that require high alertness, such as driving, before knowing how your body responds to this medication
• Metformin can cause changes in the menstrual cycle (promote ovulation) and increase the chance of an unplanned pregnancy. Consult with your doctor about using birth control that suits your condition
• Tell your doctor if you plan to become pregnant or are pregnant. Your doctor may provide other, safer treatment alternatives if you need blood sugar control during pregnancy

Is Kombiglyze XR safe for pregnant and lactating women?

Animal studies have shown no risk, but there has not been adequate research conducted in pregnant women. The US Food and Drug Administration (FDA) classifies this drug into category B (no risk in some studies).

Metformin is known to pass along with breast milk in small amounts. Even so, it is not known whether saxagliptin also comes out with breast milk. Consult your doctor before giving breast milk.

Drug Interactions

Drug interactions can change how medications work or increase the risk of side effects. The following list does not contain all drugs that may cause drug interactions. Tell your doctor if you are on medication, especially for drug consumption:

• Antibiotic or antifungal
• Insulin or other oral diabetes medication
• Medicines to treat HIV or AIDS
• CYP3A4 / 5 inhibitors, eg diltiazem, ketoconazole
• Rifampin
• Glucocorticoids
• Diuretic

Keep a list of all the medicines you take and inform your doctor before taking Kombiglyze XR, including prescription, non-prescription, vitamin, or herbal medicines.

Overdose

What should I do in an emergency or overdose?

In case of an emergency or overdose, call emergency medical help immediately (119) or rush to the nearest hospital emergency department for help. Kombiglyze XR overdose can cause lactic acidosis. Hypoglycemia is also a condition that occurs as a result of an overdose, the symptoms of which include:

• Very, very tired
• Nausea
• Shaky
• Sweating
• Confusion
• Difficulty communicating
• Fast heart rate
• Seizures

What if I forget my medication schedule?

Take the missed dose as soon as you remember. However, skip the forgotten schedule if the distance gets too close to the next schedule. Continue taking medication on a regular schedule. Do not double your dose on a single medication schedule.