Isosorbide dinitrate (ISDN): function, dosage, side effects, how to use

Isosorbide Dinitrate (ISDN) What Medicine?

What is isosorbide dinitrate (ISDN) used for?

Isosorbide dinitrate (ISDN) is a medication to treat chest pain (angina) in people with certain heart conditions, such as coronary heart disease.

This drug belongs to the class of vasodilator drugs. This drug works to relax and dilate blood vessels so that blood can flow more smoothly.

How do I use the drug isosorbide dinitrate (ISDN)?

ISDN drugs can be taken before or after meals. Make sure you follow the rules for taking the medication given by your doctor.

For the drug in tablet form, you should not crush or crush the tablet. This is because grinding the drug without the doctor's instructions can affect the performance of the drug itself.

If you really have trouble swallowing the drug without crushing it first, consult this with your doctor. Your doctor may be able to prescribe other drug options, such as liquid drugs or tablets that can be dissolved in water. For injection drugs, follow the rules of use given by the doctor and medical team.

Use this remedy regularly for maximum benefits.

Do not use this medication for more than the recommended dose, for less, or for longer than the recommended dosage. If your condition gets worse or shows no change, consult a doctor immediately.

How to store this drug?

Store ISDN in a place with room temperature, which is about 25-30 degrees Celsius. Keep away from direct light and damp places. Don't keep it in the bathroom. Don't freeze it.

Other brands of this drug may have different storage rules. Observe the storage instructions on the product package or ask your pharmacist. Keep all medicines away from children and pets.

Do not flush your medication down the toilet or down the drain unless instructed to do so. Discard this product when the drug has expired or when it is no longer needed.

Consult your pharmacist or local waste disposal agency about how to safely dispose of your medicine.

Isosorbide Dinitrate (ISDN) Dosage

The information provided is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist before starting treatment.

What is the dose of isosorbide dinitrate (ISDN) for adults?

ISDN dosage for acute angina

• 2.5 mg - 10 mg under the tongue (sublingual)

ISDN dosage for congestive heart failure

• Sublingual tablet: 5-10 mg every 2 hours
• Oral tablet: 30-160 mg per day in divided doses. The maximum dose is 20 mg per day

What is the dose of isosorbide dinitrate (ISDN) for children?

There is no set dosage for isosorbide dinitrate for children. This medicine can be dangerous for children.

It is important to understand the safety of drugs before use. Please consult your doctor or pharmacist for more information.

In what dosage is isosorbide dinitrate (ISDN) available?

ISDN drugs are available in the following preparations:

• Capsule, sustained-release 40 mg
• Tablet, sustained-release 40 mg
• Tablet, sublingual 2.5 mg, 5 mg
• 5 mg, 10 mg, 40 mg tablets

Isosorbide Dinitrate (ISDN) side effects

What are the side effects of ISDN?

Usually, the side effects of drugs can go away on their own without needing to be treated. However, if the side effects do not go away, contact your doctor immediately.

Some of the side effects of ISDN that may occur are:

• dizzy
• headache
• nausea
• gag

If you experience a severe allergic (anaphylactic) reaction to this medicine, seek medical attention immediately. Symptoms of an allergic reaction can include:

• itchy rash
• difficulty breathing
• swelling of the face, lips, tongue, or throat.

Not everyone experiences drug side effects. There may be some side effects not listed above.

If you have concerns about certain side effects, consult your doctor or pharmacist.

Drug Isosorbide Dinitrate (ISDN) Warnings and Cautions

What should be known before taking isosorbide dinitrate?

Before taking medication, it is important that you consider all the benefits and risks of this medicine.

The reason is, this drug should not be used carelessly. Some things that are important for you to know before using ISDN drugs are:

• Tell your doctor if you have a history of allergies to certain drugs or unusual symptoms after using this medicine or any other medicines.
• Tell your doctor about all medications you are currently taking, including vitamins, supplements, and herbs.
• Tell your doctor if you are pregnant or breastfeeding.
• If you have bleeding in the brain, an overactive thyroid, heart problems (for example, heart failure, cardiomyopathy, history of heart attack), or anemia.
• You are using avanafil, riociguat, sildenafil, tadalafil, or vardenafil.

There may be other things not mentioned above. If you have other questions, please consult a doctor for more information.

Your doctor may provide more complete information, including the dosage, safety, and interactions of these drugs.

Listen carefully to all the information explained by the doctor so that the treatment you are doing runs optimally.

Is isosorbide dinitrate safe for pregnant and lactating women?

This drug is included in the pregnancy risk category C (possibly risky) according to the US Food and Drug Administration (FDA) United States, which is the equivalent agency of the POM in Indonesia. The following references the pregnancy risk categories according to the FDA:

• A = Not at risk
• B = No risk in several studies
• C = May be risky
• D = There is positive evidence of risk
• X = Contraindicated
• N = Unknown

Meanwhile, it is not known whether this drug is absorbed into breast milk (ASI) or not. If you are breastfeeding and need heart attack medication, consult your doctor first.

Isosorbide Dinitrate (ISDN) Drug Interactions

What medicines may interact with isosorbide dinitrate (ISDN)?

Although certain drugs are not recommended to be used together, in other cases two different drugs can be used together even though drug interactions may occur.

In these cases, your doctor may change the dose, or other precautions need to be taken. Tell your doctor if you are using any other prescription or nonprescription drugs.

Side effects in the form of hypotension, anemia, and cardiogenic shock may get worse if ISDN is combined with hypertension drugs such as:

• sildenafil
• tadalafil
• vardenafil

Also, avoid using drugs such as NSAIDs while using ISDN. NSAID drugs such as ibuprofen and naproxen have a risk of worsening your heart failure condition.

Can food or alcohol interact with isosorbide dinitrate (ISDN)?

Certain drugs should not be used when eating certain foods because drug-food interactions can occur.

Smoking tobacco or consuming alcohol with certain drugs can also cause interactions to occur.

Discuss your use of drugs with food, alcohol, or tobacco with your health care provider.

What health conditions may interact with the drug isosorbide dinitrate (ISDN)?

Some of the health problems that can interact with ISDN drugs are:

• Congestive heart failure
• Heart attack
• Hypertrophic cardiomyopathy
• Hypotension (low blood pressure)
• Hypovolemia (low blood count)

Isosorbide Dinitrate (ISDN) overdose

What should I do in an emergency or overdose?

In case of an emergency or signs of an overdose, contact the emergency services provider (118 or 119) or immediately to the nearest hospital emergency department.

What should I do if I miss a dose?

If you forget a dose of this medicine, take it as soon as possible. However, when it is nearing the time of the next dose, skip the missed dose and return to the usual dosing schedule. Make sure you don't double your dose in one shot.