Gliclazide: functions, dosage, side effects, how to use it

What Drug Gliclazide?

What is gliclazide used for?

Gliclazide is a type of oral medicine in the form of tablets. This drug is available in various preparations, ranging from 40 milligrams (mg), 60 mg, up to 80 mg. This drug belongs to the sulfonylurea drug class, namely anti-diabetic drugs.

This drug is used to control blood sugar levels in patients with type 2 diabetes. The use of this drug is included in a series of treatments to control high blood sugar levels in patients with non-insulin dependent diabetes (who are not dependent on insulin). This treatment is also accompanied by adjusting a healthy diet and exercising.

Controlling high blood sugar levels helps prevent heart disease, stroke, kidney, circulation problems, and blindness. This drug is included in the type of prescription drug, which can only be purchased at a pharmacy if accompanied by a prescription from a doctor.

How do I use gliclazide?

Here are some ways to look for when using gliclazide, including:

• Use this medication according to the instructions given by your doctor.
• This medication is best taken with food. Take this medication at the same time every day.

How is gliclazide stored?

This medication is best stored at room temperature, away from direct light and damp places. Don't keep it in the bathroom. Don't freeze it. Other brands of this drug may have different storage rules. Observe the storage instructions on the product package or ask your pharmacist. Keep all medicines away from children and pets.

Do not flush medicines down the toilet or down the drain unless instructed to do so. Discard this product when it has expired or when it is no longer needed. Consult your pharmacist or local waste disposal company about how to safely dispose of your product.

Gliclazide dosage

The information provided is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist before starting treatment.

What is the dosage for gliclazide for adults?

Adult dosage for type 2 diabetes mellitus

• Initial dose: 40-80 mg daily
• This dose can be increased to 320 mg daily if necessary.
• Doses> 160 mg per day may be given in two separate doses.
• For modified release tab: Initial dose is 30 mg once per day, possibly increased to 120 mg per day.

What is the dose of gliclazide for children?

There is no provision for the dosage of this drug for children. This medicine can be dangerous for children. It is important to understand the safety of drugs before use. Consult your doctor or pharmacist for more information.

In what dosage is gliclazide available?

Gliclazide is available in tablet form: 40 mg, 60 mg, 80 mg.

Gliclazide side effects

What side effects can be experienced due to gliclazide?

As with drug use in general, use of this drug may also cause symptoms of drug side effects. One of the most common side effects is hypoglycemia, or lack of blood sugar levels in the body.

If you continue to do so, then you may become drowsy as a result, pass out or maybe go into a coma. If low blood sugar levels become severe or prolonged, even if controlled by consuming sugar, you need to seek immediate medical attention, if you experience any of the following conditions. :

• blood disorders
• reported reduction in the number of cells in the blood (e.g. platelets, red and white blood cells)

Hypoglycemia may cause:

• pale
• prolonged bleeding
• bruise
• sore throat
• fever
• fatigue, difficulty breathing
• nosebleed
• mouth ulcers, chills

However, these symptoms usually go away if treatment is stopped.

There are also other symptoms of serious side effects, such as the following:

• Liver dysfunction (characterized by jaundice or eyes and skin turning yellow)
• Skin problems, such as a severe allergic reaction (characterized by skin rash, redness, angiodema or rapid swelling of tissues such as the eyelids, face, lips, mouth, tongue or throat that may make breathing difficult)
• skin reaction to sunlight (hypersensitivity)
• Digestive disorders include abdominal pain or discomfort
• feel or are not feeling well
• gag
• indigestion
• diarrhea
• Constipation
• Your vision may be affected in the short term especially at the start of treatment. This effect is due to changes in blood sugar levels.

Not everyone experiences this side effect. There may be some side effects not listed above. If you want to know about side effects, consult your doctor or pharmacist.

Gliclazide Drug Warnings and Cautions

What should be known before using gliclazide?

Before using this drug, there are a number of things you should know and do, as follows.

• Tell your doctor if you have an allergy to gliclazide or other drug ingredients, or other similar drugs (sulphonylureas and hypoglycemic sulphonamides).
• Tell your doctor if you have diabetes which must be dependent on insulin (type 1)
• Tell your doctor if you have severe kidney or liver problems
• Tell your doctor if you have diabetes complications with ketosis or acidosis
• Tell your doctor if you have pre-coma and coma due to diabetes
• Tell your doctor if you are taking medication to treat a yeast infection
• Tell your doctor if you are breastfeeding (see pregnancy, breastfeeding and fertility sections)
• Tell your doctor if you have diabetes and have had surgery after an impact or during a serious infection
• Tell your doctor if you have porphyria (an inherited disease that affects the liver or bone marrow).
• This medicine should not be given to children to treat diabetes.

Is gliclazide safe for pregnant and lactating women?

There is no adequate research on the risks of using this drug in pregnant or breastfeeding women. Always consult your doctor to weigh the potential benefits and risks before using this medication. This drug is included in the risk of pregnancy category N according to the US Food and Drug Administration (FDA) in America or the equivalent of the Food and Drug Administration (BPOM) in Indonesia. The following references the pregnancy risk categories according to the FDA:

• A = No risk,
• B = not at risk in several studies,
• C = May be risky,
• D = There is positive evidence of risk,
• X = Contraindicated,
• N = Unknown

Gliclazide Drug Interactions

What medicines may interact with gliclazide?

Drug interactions may change how medications work or increase the risk of serious side effects. This article does not contain all possible drug interactions. Write down all the products you use (including prescription / nonprescription drugs and herbal products) and tell your doctor and pharmacist. Do not start, stop, or change your dose without your doctor's approval.

The effect of gliclazide which reduces blood sugar levels may increase and signs of low blood sugar levels may appear when one of the following drugs is used:

• other drugs useful for treating high blood sugar levels (oral antidiabetics, glp-1 receptor blockers or insulin)
• antibiotics (eg sulphonamides, clarithromycin)
• medications for high blood pressure or heart failure (beta blockers, antiarhythmic, ace inhibitors such as captopril or enalapril)
• yeast infection drugs (miconazole, fluconazole)
• duodenum ulcer medication (h2 receptor antagonists)
• depression medication (monoamine oxidase inhibitors), pain relievers or antirheumatic drugs (phenylbutazone, ibuprofen)
• drugs containing alcohol
• sulphonamide antibiotics, eg sulfamethoxazole, co-trimoxazole
• antibacterial components including clarithromycin, tetracycline, oral forms of miconazole, trimethoprim, and chloramphenicol
• medications to reduce high blood lipid levels (lipid-reducing agents such as clofibrate)
• hormones like testosterone or octreotide
• gout medications (for example sulfinpyrazone)
• breast or prostate cancer drugs (example: aminoglutethimide)
• thyroid hormone to treat thyroid problems, eg thyroxine

The effect of gliclazide which reduces blood glucose may weaken or even increase blood sugar levels. It may appear if you use any of the following medicines:

• central nervous system disorder drugs (chlorpromazine), drugs that reduce inflammation (corticosteroids)
• drugs to treat asthma or useful during labor (intravenous salbutamol, ritodrine, and terbutaline)
• drugs for breast disorders, heavy menstrual bleeding and endometriosis (danazol)
• laxatives for constipation, eg magnesium hydroxide
• adrenocorticotropic hormone which is useful in the treatment of adrenal deficiency of nerve origin, for example tetracosactrin
• gliclazide might increase the effect of drugs that reduce blood clotting (eg warfarin)

Consult your doctor before starting treatment.

Can food or alcohol interact with gliclazide?

Certain drugs cannot be used with meals or when eating certain foods because drug interactions can occur. Consuming alcohol or tobacco with certain drugs can also cause interactions to occur. Talk to your healthcare professional about using your medication with food, alcohol, or cigarettes.

What health conditions can interact with gliclazide?

The presence of other medical problems may affect medication use. Make sure you tell your doctor if you have any other medical problems, especially:

• if you have kidney or liver problems
• if you are told that you have porphyria or a glucose 6-phosphate dehydrogenase (G6PD) deficiency, which is a rare inherited disorder

Gliclazide overdose

What should I do in an emergency or overdose?

In case of an emergency or overdose, contact the local emergency services provider (112) or immediately to the nearest hospital emergency department.

What should I do if I miss a dose?

If you forget a dose of this medicine, take it as soon as possible. However, when it is near the time of the next dose, skip the missed dose and return to the usual dosing schedule. Do not double up on a dose to make up for a missed dose. This is because double doses do not guarantee you will recover faster and can increase the risk of side effects of use.

Hello Health Group does not provide medical advice, diagnosis or treatment.