Clomipramine: functions, dosage, side effects, how to use

What drug Clomipramine?

What is clomipramine for?

Clomipramine is a drug used to treat obsessive compulsive disorder (OCD). This medication helps reduce persistent / unwanted thoughts (obsessions), and helps reduce the urge to perform repetitive actions (urges such as washing hands, counting, checking) that interfere with daily life.

Clomipramine is a drug that belongs to a class of drugs called tricyclic antidepressants. It works by restoring the balance of certain natural substances (such as serotonin) in the brain.

OTHER USES: This section lists uses for this drug that are not listed on approved labels, but may be prescribed by your healthcare professional. Use this medication for the conditions listed below only if it has been prescribed by your doctor and health care professional.

Clomipramine is a drug that has also been used to treat depression, panic attacks, and ongoing pain.

Clomipramine dosage

How to use Clomipramine?

Read the Medication Guide available from your pharmacist. Consult your doctor or pharmacist if you have any questions.

Take this medication with or without food as directed by your doctor. To reduce side effects such as stomach upset, clomipramine can be started at a low dose, given in several doses during the day with meals, and slowly increase as your body becomes accustomed to this drug. Once you have reached the dose that is best for you, the total dose may be taken once daily, usually at bedtime to prevent daytime drowsiness or as directed by your doctor. Typically, the daily dose will be no more than 250 milligrams for adults and 200 milligrams for children and adolescents.

Follow the doctor's instructions carefully. Do not cut back on your medication or use your medication more often than recommended. Your condition will not improve any faster and the risk of side effects such as seizures may increase. Dose is based on your medical condition and response to treatment.

Avoid eating grapefruit or drinking grapefruit juice while using this medicine unless your doctor has instructed you otherwise. Grapefruit can increase the amount of certain drugs in your bloodstream. Consult your doctor or pharmacist for more details.

Use this remedy regularly to get its benefits. Continue using even if you feel well. To help you remember, use it at the same time every day.

Do not suddenly stop taking this medication without consulting your doctor. Some conditions can get worse when the use of this drug is suddenly stopped. You may experience sweating, dizziness, nausea, vomiting, headache, or irritability if you suddenly stop taking this medicine. dose You may need to decrease the dose gradually.

It may take 2 to 3 weeks or more before the full effects of this drug are felt. Tell your doctor if your condition does not improve or if it gets worse.

Follow the rules given by your doctor or pharmacist before starting treatment. If you have any questions, consult your doctor or pharmacist.

How is Clomipramine stored?

Clomipramine is best stored at room temperature, away from direct light and damp places. Don't keep it in the bathroom. Don't freeze it. Other brands of this drug may have different storage rules. Observe the storage instructions on the product package or ask your pharmacist. Keep all medicines away from children and pets.

Do not flush medicines down the toilet or down the drain unless instructed to do so. Discard this product when it has expired or when it is no longer needed. Consult your pharmacist or local waste disposal company about how to safely dispose of your product.

Clomipramine side effects

The information provided is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist before starting treatment.

What is the dose of clomipramine for adults?

Adult Dose for Depression:

Initial dose: 25 mg orally once a day at bedtime.
Maintenance dose: May be increased to 100 mg per day for the first 2 weeks.
Maximum dose: 250 mg per day

Adult Dose for Obsessive Compulsive Disorder:

Initial dose: 25 mg orally once a day at bedtime.
Maintenance dose: May be increased to 100 mg per day for the first 2 weeks.
Maximum dose: 250 mg per day

Adult Dose for Panic Disorder:

Initial dose: 25 mg orally once a day at bedtime.
Maintenance dose: May be increased to 100 mg per day for the first 2 weeks.
Maximum dose: 250 mg per day

What is the dosage of Clomipramine for children?

10 to 17 years old

Initial dose: 25 mg orally once a day at bedtime.

Maintenance dose: May increase to 3 mg / kg or 100 mg, whichever is less during the first 2 weeks.
Maximum dose: 3 mg / kg / day or 200 mg, whichever is the smaller dose

In what dosage is Clomipramine available?

Clomipramine is a drug that is available in capsules of 25 mg, 50 mg, 75 mg

Clomipramine Drug Warnings and Cautions

What side effects can be experienced due to clomipramine?

Get emergency medical help if you have signs of an allergic reaction: hives difficulty breathing swelling of the face, lips, tongue, or throat.

Clomipramine is a drug that can cause side effects. Get emergency medical help if you have signs of an allergic reaction: hives difficulty breathing swelling of the face, lips, tongue, or throat.

Report any new symptoms or if certain symptoms worsen with your doctor, such as: mood swings or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, restless, hostile, aggressive, restless, hyperactive ( mentally or physically), is more depressed, or has thoughts of suicide or hurting yourself.

Call your doctor if you have:

fast heart rate, tremors or shaking
confusion, extreme fear, thoughts of self-harm
agitation, hallucinations, fever, overactive reflexes, vomiting, diarrhea, loss of coordination, fainting
urinating painful or difficult to urinate
very stiff (rigid) muscles
convulsions (convulsions)
feeling tired, weak, bruising or bleeding easily (nosebleeds, bleeding gums), pale skin, feeling dizzy or short of breath;

Common side effects may include:

dry mouth, nausea, stomach pain, loss of appetite, constipation
feeling anxious, restless, dizzy, drowsy, or tired
sleep problems (insomnia)
changes in appetite or weight
memory problems, trouble concentrating
increased sweating, numbness or tingling
vision changes
decreased sex drive, impotence, or difficulty having an orgasm

Not everyone experiences the following side effects. There may be some side effects not listed above. If you have concerns about certain side effects, consult your doctor or pharmacist.

Clomipramine Drug Interactions

What should be known before using clomipramine?

In deciding to use a drug, the risks of using the drug must be weighed against its benefits. It is up to you and your doctor. For this drug, the following should be considered:

Allergy

Tell your doctor if you have ever had an unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to food, coloring, preservatives, or animals. For non-prescription products, read ingredients labels or packages carefully.

Children

Appropriate studies have not been conducted on the relationship of age to the effects of clomipramine in children younger than 10 years. Safety and efficacy have not been established.

Elderly

The precise studies conducted to date have not shown specific problems in older people that will limit the usefulness of clomipramine in older people. However, elderly patients are more likely to have age-related kidney, liver, or heart problems, which may require adjusting the dose for patients receiving clomipramine.

Is clomipramine safe for pregnant and lactating women?

There is no adequate research on the risks of using this drug in pregnant or breastfeeding women. Always consult your doctor to weigh the potential benefits and risks before using this medication. This drug is included in the risk of pregnancy category C according to the US Food and Drug Administration (FDA).

The following references the pregnancy risk categories according to the FDA:

A = No risk,
B = not at risk in several studies,
C = May be risky,
D = There is positive evidence of risk,
X = Contraindicated,
N = Unknown

Studies in women show that this drug poses minimal risk to the baby when used during breastfeeding.

Clomipramine overdose

What medicines may interact with clomipramine?

Clomipramine is a drug that can interact with other drugs. Although certain drugs should not be used simultaneously, in other cases two different drugs can be used together even if interactions are possible. In this case, your doctor may want to change the dose, or take other precautions that may be needed. Tell your health care professional if you are taking prescription drugs or other drugs on the market.

Using this medication with any of the following medicines is not recommended. Your doctor may decide not to treat you with this drug or change some of the other medicines you take.

Amifampridine
Bepridil
Cisapride
Dronedarone
Furazolidone
Grepafloxacin
Iproniazid
Isocarboxazid

Can food or alcohol interact with Clomipramine?

Certain drugs should not be used with meals or when eating certain foods because drug interactions can occur. Consuming alcohol or tobacco with certain drugs can also cause interactions to occur. Discuss your use of drugs with food, alcohol, or tobacco with your health care provider.

What health conditions may interact with Clomipramine?

The presence of other health problems in your body may affect the use of this medicine. Tell your doctor if you have other health problems .:

adrenal gland tumors (for example, neuroblastoma, pheochromocytoma)
heart disease
hyperthyroidism (overactive thyroid) - use with caution. May cause side effects to be worse
behavior changes or mood changes (for example, aggression, panic attacks)
bipolar disorder (mood disorder with mania and depression), or risk
depression, history of depression
glaucoma (angle closed type)
Kidney illness
liver disease
mania or hypomania, history of this disease
psychosis (mental illness)
schizophrenia (mental illness)
seizures, history of seizures
urinary retention (difficulty urinating), a history of the disease - Use with caution. It might make things worse
heart attack, recently had a heart attack - should not be used in patients with this condition

Overdose

What should I do in an emergency or overdose?

The presence of other health problems in your body may affect the use of this medicine. Tell your doctor if you have other health problems .:

adrenal gland tumors (for example, neuroblastoma, pheochromocytoma)
heart disease
hyperthyroidism (overactive thyroid) - use with caution. May cause side effects to be worse
behavior changes or mood changes (for example, aggression, panic attacks)
bipolar disorder (mood disorder with mania and depression), or risk
depression, history of depression
glaucoma (angle closed type)
Kidney illness
liver disease
mania or hypomania, history of this disease
psychosis (mental illness)
schizophrenia (mental illness)
seizures, history of seizures
urinary retention (difficulty urinating), a history of the disease - Use with caution. It might make things worse
heart attack, recently had a heart attack - should not be used in patients with this condition

What should I do if I miss a dose?

In case of an emergency or overdose, contact the local emergency services provider (112) or immediately to the nearest hospital emergency department.

Overdose symptoms may include:

- seizures
- coma (loss of consciousness for a period of time)
- drowsiness
- anxiety
- lose coordination
- sweating
- stiff muscles
- unusual movements
- fast heart rate
- breathing slows down
- blue discoloration of the skin
- fever
- dilated pupils (dark circle in the center of the eye)
- decreased urination