Anakinra: functions, dosage, side effects, how to use it

Use

What is the function of Anakinra?

Anakinra is a medicine to treat rheumatoid arthritis (rheumatism). This medication helps slow joint damage and reduce joint pain from rheumatoid arthritis so that you can move more easily.

Anakinra is a processed form of natural protein (interleukin-1 receptor antagonist) that is produced by the body. This medication also helps block the effects of another protein (interleukin-1) that can cause joint pain / swelling / stiffness.

Anakinra is also used to treat a condition called Neonatal-Onset Multisystem Inflammatory Disease (NOMID), by treating symptoms such as fever, rash, joint pain, vomiting and headaches.

How to use Anakinra?

There are several things you should pay attention to when using this drug, namely:

If you inject yourself

• Pay attention to the correct way of injecting from the doctor and what to prepare.
• Injected into the skin, usually once or as directed by a doctor.
• Do not shake this drug because it can damage the womb.
• Watch to see if the medicine changes color. If so, let the medicine sit for 30 minutes at room temperature before using it.
• Clean the injection area with alcohol.
• Do not inject this medicine into areas that are sensitive, red, bruised, hard or have scars or stretch marks.
• Use this drug regularly for optimal benefits. To help you remember, take this medication at the same time every day.
• Do not reuse needles. Learn how to store and safely dispose of needles and other medical equipment.
• Tell your doctor if your condition does not improve or if it gets worse.

How is Anakinra stored?

This medication is best stored at room temperature, away from direct light and damp places. Do not store in the bathroom and do not freeze.

Other brands of this drug may have different storage rules. Observe the storage instructions on the product package or ask your pharmacist. Keep all medicines away from children and pets.

Do not flush medicines down the toilet or down the drain unless instructed to do so. Discard this product when it has expired or when it is no longer needed. Consult your pharmacist or local waste disposal agency about how to safely dispose of your product.

Dose

The information provided is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist before starting treatment.

What is the dosage for Anakinra for adults?

100 mg injected once a day. Do not increase your dose than you should because a higher dose does not imply a faster or better response.

What is the dosage for Anakinra for children?

Initial dose: 1-2 mg / kg injected once a day
Maximum dose: 8 mg / kg injected once a day

In what dosage is Anakinra available?

Anakinra is available in the following doses:

Liquid 100 mg per 0.67 mL

Side effects

What side effects can be experienced due to Anakinra?

Seek immediate medical help if you experience any of the following signs of an allergic reaction: hives, difficulty breathing, swelling of the face, lips, tongue, or throat.

Serious infections can occur during treatment with anakinra. Stop treatment and contact your doctor immediately if you experience signs of infection such as:

• Fever, sweating, chills, tired
• Hard to breathe
• Cough, sore throat
• Sores in the mouth or throat
• Flu symptoms, weight loss.

Less serious side effects, such as:

• Nausea, diarrhea, stomach pain
• Headache
• Flu symptoms, such as stuffy nose, sneezing, sore throat
• Redness, bruising, pain or swelling at the injection site.

Not everyone experiences the following side effects. There may be some side effects not listed above. If you have concerns about certain side effects, consult your doctor or pharmacist.

Precautions & Warnings

What should be known before using Anakinra?

Before using Anakinra:

• Tell your doctor and pharmacist if you are allergic to Anakinra, a protein made from bacterial cells (E. coli), latex or other drugs.
• Tell your doctor and pharmacist what prescription or nonprescription medications, vitamins, supplements and herbal products you are using. Be sure to mention the following drugs:
  • etanercept (Enbrel)
  • infliximab (Remicade)
  • drugs that suppress the immune system, such as:
    • azathioprine (Imuran)
    • cyclosporine (Neoral, Sandimmune)
    • methotrexate (Rheumatrex)
    • sirolimus (Rapamune), and tacrolimus (Prograf)
• Tell your doctor if you have an infection, asthma, HIV infection or AIDS, or other kidney disease.
• Tell your doctor if you are or plan to become pregnant or are breastfeeding. If you become pregnant while using anakinra, contact your doctor.
• If you are having surgery, including dental surgery, tell your doctor if you are using anakinra.
• Do not get vaccinated (measles or flu shot) without informing your doctor.

Is Anakinra safe for pregnant and lactating women?

There is no adequate research on the risks of using this drug in pregnant or breastfeeding women. Always consult your doctor to weigh the potential benefits and risks before using this medication. This drug is included in the risk of pregnancy category B according to the US Food and Drug Administration (FDA).

The following references the pregnancy risk categories according to the FDA:

• A = No risk,
• B = not at risk in several studies,
• C = May be risky,
• D = There is positive evidence of risk,
• X = Contraindicated,
• N = Unknown.

Interaction

What medicines may interact with Anakinra?

Drug interactions can change the performance of your medications or increase the risk of serious side effects. Not all possible drug interactions are listed in this article.

Keep a list of all the products you use (including prescription / non-prescription drugs and herbal products) and consult your doctor or pharmacist. Do not start, stop, or change the dose of any medication without your doctor's approval.

Anakinra can interact with 448 types of drugs, but the most frequently interacting are:

• Biaxin (clarithromycin)
• carvedilol (Coreg, Coreg CR)
• Cymbalta (duloxetine)
• Enbrel (etanercept)
• Flexeril (cyclobenzaprine)
• folic acid (Folvite, Folacin-800, FA-8, FaLessa)
• furosemide (Lasix, Diaqua-2, Lo-Aqua)
• Lasix (furosemide)
• Lyrica (pregabalin)
• metformin (Glucophage, Glumetza, Fortamet, Glucophage XR, Riomet)
• methotrexate (Otrexup, Trexall, Rasuvo, Methotrexate LPF Sodium, Xatmep, Rheumatrex Dose Pack, Folex PFS)
• Neurontin (gabapentin)
• Nexium (esomeprazole)
• Orfadine (nitisinone)
• oxycodone (OxyContin, Roxicodone, Xtampza ER, OxyIR, Oxaydo, Dazidox, Oxyfast, Oxecta, RoxyBond, Oxydose, Percolone, M-Oxy, ETH-Oxydose, Endocodone, Roxicodone Intensol)
• prednisone (Deltasone, Rayos, Sterapred, Prednicot, Sterapred DS, Liquid Pred, Meticorten, Orasone, Prednicen-M)
• tramadol (Ultram, Tramadol Hydrochloride ER, Tramal, Ultram ER, Tramahexal, ConZip, Larapam SR, Ryzolt, Tramal SR, GenRx Tramadol, Tramahexal SR, Tramedo, Zydol, Zamadol, Zydol XL, Rybix ODT, Ultram ODT)
• trazodone (Desyrel, Oleptro, Desyrel Dividose)
• Tylenol (acetaminophen)
• Vitamin B12 (cyanocobalamin)
• Xanax (alprazolam)

Can food or alcohol interact with Anakinra?

Certain drugs should not be used with meals or when eating certain foods because drug interactions can occur. Consuming alcohol or tobacco with certain drugs can also cause interactions to occur. Discuss your use of drugs with food, alcohol, or tobacco with your health care provider.

What health conditions can interact with Anakinra?

Any other health conditions you have can affect the use of this drug. Always tell your doctor if you have other health problems, especially:

• Allergy to E. coli derived proteins
• Infectious, active - Should not be given to patients with this condition
• Cancer
• Infections, chronic (long term)
• Weak immune system - It is not known whether this drug can make this condition worse
• Kidney disease - Higher levels of anakinra in the blood may occur and the doctor may change the dose
• Tuberculosis, inactivity - May increase the risk of becoming active again.

Overdose

What should I do in an emergency or overdose?

In case of an emergency or overdose, contact the local emergency services provider (119) or immediately to the nearest hospital emergency department.

What should I do if I miss a dose?

If you forget a dose of this medicine, use it as soon as possible. However, when it is nearing the time of the next dose, skip the missed dose and return to the usual dosing schedule. Don't double the dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.