Synjardy: functions, dosage, side effects, how to use it

Function

What medicine is Synjardy?

Synjardy is an oral drug consisting of two active ingredients, namely empagliflozin and metformin, which is intended for adult patients with type two diabetes. This drug is not used to treat patients with type one diabetes and patients with diabetic ketoacidosis. The use of this drug accompanied by diet and physical exercise will bring optimal results in controlling blood sugar so as to avoid the risk of complications.

This drug works by helping to restore the body's response to insulin. Synjardy works by helping the kidneys not to re-absorb sugar and will excrete it through the urine through the work of empagliflozin. Meanwhile, metformin, which is also one of its components, works by reducing the amount of sugar produced by the liver and making the intestines absorb less glucose. Synjardy has also been shown to be useful in reducing the risk of death from heart disease, stroke and heart failure for people with type two diabetes.

Rules of use Synjardy

Synjardy is an oral medication that is usually taken twice a day. Take this medication in its entirety, do not split, crush, or chew it. Take Synjardy at the same time as meals to avoid stomach upset. To make it easier for you to remember, take this medication at the same time each day.

At the start of treatment using Synjardy, your doctor may start with a low dose first and then increase it gradually to avoid the side effects of metformin consumption. Take Synjardy as prescribed by your doctor. Do not reduce or increase the dose without consulting your doctor. The dose given has adjusted to your health condition and your body's response to treatment.

How do I save Synjardy?

Store this drug at room temperature between 15-30 degrees Celsius. Avoid from light and direct sunlight. Do not store this medication in a humid room, such as in the bathroom. Keep out of reach of children to avoid risk of poisoning.

Do not flush this down the toilet or drain unless instructed to do so. Consult your pharmacist or local waste disposal company about how to safely dispose of your product.

Dose

The information provided is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist before starting treatment.

Synjardy dosage (empagliflozin / metformin) for adult patients

Empagliflozin / metformin immediate release

Initial dose switch to Synjardy:

• Patients on metformin therapy: switch to Synjardy which contains 5 mg of empagliflozin and the same amount of daily dose for metformin, twice daily
• Patients on empagliflozin therapy: switch to Synjardy which contains 500 mg of metformin and the same amount of daily dose of empagliflozin, twice daily
• Patients who have taken empagliflozin / metformin: switch to Synjardy with the same dosage as each component has been consumed

Empagliflozin / metformin extended release tablet

• Patients on metformin: switch to Synjardy extended release tablets with the same dose of metformin and total daily dose of empagliflozin 10 mg, once daily
• Patients on empagliflozin: switch to Synjardy extended release tablets containing the same total daily dose of empagliflozin and metformin 1,000 mg, once daily
• Patients who have taken empagliflozin / metformin: switch to the Synjardy extended release tablet which contains the same dosage as that which has been taken, once daily
• Maximum daily dose: 25 mg empagliflozin and 2,000 mg metformin per day

In what dosage and preparation is Synjardy available?

Tablet, Oral: 5mg / 500mg; 5mg / 1,000mg; 12.5mg / 500mg; 12.5 / 1.000mg (immediate release). Extended release tablet: 5mg / 1,000mg; 10mg / 1,000mg; 12.5mg / 1,000mg; 25mg / 1,000mg

Side effects

What side effects may occur due to consumption of Synjardy?

Headache, diarrhea, nausea, vomiting, runny nose, or sore throat may occur as a result of taking this medicine. If these symptoms persist or get worse, contact your doctor immediately.

If you experience stomach pain at the start of treatment, contact your doctor. These symptoms can be an indication of the accumulation of lactic acid due to the consumption of metformin. Call your doctor if you have unexplained muscle pain, stomach pain, extreme fatigue, vomiting, unusual heartbeat, or feeling weak.

Some of the serious side effects of taking this drug are:

• Urinary tract infection. It is characterized by pain or burning when urinating, increased urine output, bloody urine, pain in the pelvis or lumbar bones.
• Genital infection (penis or vagina) which is characterized by pain, burning, itching, rash, redness, bad odor, or abnormal vaginal discharge.
• Dehydration. Consumption of this drug can cause dehydration which will lead to kidney problems if not followed up. Some signs are weakness, lightheadedness (as if you were going to fall), and dizziness.
• Allergic reactions due to this drug are rare. However, call your doctor if you notice allergy symptoms such as itching, skin redness, swelling of the face, tongue, or throat, and difficulty breathing.

The list above may not include all the side effects caused by consumption of Synjardy. Talk to your doctor about any possible side effects that you are concerned about.

Warnings and Precautions

What should I know before taking Synjardy?

• Tell your doctor about any history of any drug allergies you have, including the drugs empagliflozin and metformin, as well as other medications.
• Tell your doctor about any medical history you have, along with any medical history that you have or are currently suffering from
• Tell your doctor about any medications you are currently taking, both prescription and over-the-counter medicines and herbal medicines
• If you are planning to have a radiological examination that requires injection of contrast fluid into the body, stop using this drug and consult your doctor.
• This medicine will produce high glucose in your urine because of how it works. Make sure you inform the doctor and laboratory personnel when going to do urine checks
• You may experience blurred vision, weakness and dizziness as symptoms of hypoglycemia due to decreased blood sugar due to consumption of this medicine. Don't do activities that require high alertness such as driving before you know how your body is responding to this treatment

Is Synjardy safe for pregnant and lactating women?

There are no adequate studies related to the use of Synjardy in pregnant and lactating women. However, in animal studies, empagliflozin has been shown to affect the fetus. Consider using other therapies, especially during the second and third trimesters.

Experiments carried out on mice, showed that Synjardy also passed out through breast milk. However, human trials have not been carried out. Use this medicine only if the benefits it provides outweigh the risks to the fetus.

Drug Interactions

Consumption of certain drugs at the same time as Synjardy may cause one of the drugs to not work optimally. Even so, doctors sometimes prescribe both when needed. Diuretic drugs, insulin injections, or contrast fluids used during X-ray procedures will affect Synjardy's work. Talk with your doctor about any medications you are currently taking or have stopped taking.

Overdose

What should I do if I overdose on Synjardy?

In an emergency or overdose, immediately contact emergency medical assistance (119) or immediately to the nearest hospital. Symptoms of a Synjardy overdose can include hypoglycemia characterized by weakness, nausea, trembling, rapid breathing, loss of consciousness, or difficulty breathing.

What if I forget to take medicine?

If you miss your scheduled medication, take it as soon as you remember (along with meal times). If it is too close to the schedule for taking the next medication, ignore the missed schedule and continue on the normal schedule. Do not double your dose on a single medication schedule.

Hello Health Group does not provide medical advice, diagnosis or treatment.