Nafarelin: functions, dosage, side effects, how to use it

Functions & Usage

What is Nafarelin used for?

Nafarelin is a drug used to treat endometriosis, a condition in women in which tissue that is normally in the uterus grows in the wrong place. This medication reduces abnormal tissue as well as symptoms of endometriosis (eg, pelvic pain, painful menstrual cramps, and pain during / after sex).

This drug is also used in children to treat certain types of precocious puberty (central precocious puberty, gonadotropin-dependent). This medication helps to slow bone aging and height growth rate so that it can be near normal and to stop or reverse signs of premature puberty (eg, breast growth in girls, growth of sexual organs in boys).

Nafarelin is a man-made hormone that is similar to the natural hormone made by the body (gonadotropin-releasing hormone-GnRH). This drug works by reducing the hormone testosterone in men and the hormone estrogen in women and girls.

What are the rules for using the drug Nafarelin?

Follow the instructions on the correct method if you are using it for the first time.

Gently blow your nose before using this medication. For younger children, it may be necessary to clean the nose with a spray.

Use this medication usually twice daily (every 12 hours) as directed by your doctor. If you use more than 1 spray at a time, wait 30 seconds between each spray. Avoid spraying this medicine in your eyes. Also, avoid sneezing during or immediately after using this medicine as this can decrease the amount of drug that is absorbed. Follow detailed instructions for using the spray and cleaning the nozzle. It is highly recommended that you always clean the nozzle after each use.

Dosage is based on your medical condition and response to therapy. The length of therapy for women on this medication to treat endometriosis is 6 months unless directed by your doctor to do less or more than the general duration of the therapy. The length of therapy for children experiencing precocious puberty depends on when the doctor decides the right time to resume puberty.

Use this drug regularly to get optimal benefits. To help you remember, take this medication at the same time each day.

Consult your doctor or pharmacist to find out how long each nasal spray bottle should last. Don't use the nasal spray bottle again, even though there may be some medication left, as doing so could result in you getting too low a dose. Make sure you get your medicine refills a few days early so you don't run out of medicine.

Do not increase your dose or take this drug more often than prescribed. Your condition will not improve any faster, and it may actually increase the risk of serious side effects. Also, do not stop using this drug without your doctor's approval.

If you need to use a decongestant nasal spray at the same time as this medicine, take Nafarelin first and wait at least 2 hours after you use a decongestant nasal spray.

When you first start using this medicine, your symptoms may worsen (for example, increased vaginal bleeding in endometriosis, or vaginal / menstrual bleeding, increased breast size / pubic hair, oily skin, or body odor at early puberty). Such symptoms may improve after the first month of treatment. Tell your doctor if symptoms get worse or last more than 2 months.

How to save Nafarelin?

This medication is best stored at room temperature, away from direct light and damp places. Don't keep it in the bathroom. Don't freeze it. Other brands of this drug may have different storage rules. Observe the storage instructions on the product package or ask your pharmacist. Keep all medicines away from children and pets.

Do not flush medicines down the toilet or down the drain unless instructed to do so. Discard this product when it has expired or when it is no longer needed. Consult your pharmacist or local waste disposal company about how to safely dispose of your product.

Precautions & Warnings

What should be considered before using Nafarelin?

Before using Nafarelin:

• Tell your doctor and pharmacist if you are allergic to Nafarelin or other hormone-releasing gonadotropins and medicines.
• Tell your doctor and pharmacist about any medications (prescription or non-prescription), vitamins, nutritional supplements, and any herbal products you are currently using or will use, in particular anticonvulsants to treat seizures or epilepsy. nasal decongestants, steroids, and vitamins.
• Tell your doctor if you have or have had osteoporosis or in your family any family members who have a history of osteoporosis; ovarian cysts, uterine tumors, or uterine cancer; chronic rhinitis (runny nose); or a history of depression.
• Tell your doctor if you are pregnant, plan to become pregnant or are breastfeeding. It is very important that you use contraception (birth control) while you are using Nafarelin (eg, condoms, diaphragm). If you become pregnant while using this medicine, contact your doctor immediately.

Is Nafarelin safe for pregnant and lactating women?

There are no adequate studies regarding the risks of using this drug in pregnant or breastfeeding women. Always consult your doctor to weigh the potential benefits and risks before using this medication. This medicine is included in the pregnancy risk category X. (A = No risk, B = No risk in some studies, C = Possible risk, D = There is positive evidence of risk, X = Contraindicated, N = Unknown)

It is not known whether Nafarelin passes into breast milk or if it could harm a breastfed baby. Do not breastfeed while using this medicine.

Side effects

What are the possible side effects of Nafarelin?

Seek immediate medical help if you experience any of the following signs of an allergic reaction: hives, difficulty breathing, swelling of the face, lips, tongue, or throat.

Call your doctor if you experience serious side effects, such as the following:

• Continuous / severe menstrual bleeding
• Pelvic pain or swollen pelvis
• Increased thirst, increased urge to urinate
• Seizures
• Severe chest or chest pain, pain that goes up to the arm or shoulder, nausea, sweating, overall body aches
• Sudden numbness or weakness, sudden severe headache, problems with vision, ability to speak or balance or
• Nausea, pain in the upper abdomen, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes)

Less serious side effects may include:

• Changes in breast size
• Oily skin or acne, increased body odor
• Dandruff
• The amount of pubic hair increases
• Mood changes
• Runny nose
• A sudden burning sensation
• Mild headaches, muscle aches
• Light and irregular menstrual bleeding
• Whitish discharge that is white to brownish in color or
• Dry or vaginal discharge
• Changes in sexual desire

Not everyone experiences the following side effects. There may be some side effects not listed above. If you have concerns about certain side effects, consult your doctor or pharmacist.

Drug Interactions

What drugs can interfere with the drug Nafarelin?

Drug interactions can change the performance of your medications or increase the risk of serious side effects. Not all possible drug interactions are listed in this document.

Keep a list of all the products you use (including prescription / non-prescription drugs and herbal products) and consult your doctor or pharmacist. Do not start, stop, or change the dose of any medication without your doctor's approval.

If your nose is congested during your treatment with Nafarelin, then check with your doctor before using a decongestant. If your doctor recommends a nasal decongestant spray, do not use the decongestant for at least 2 hours after you use Nafarelin.

Can certain foods and drinks interfere with the work of the drug Nafarelin?

Certain drugs should not be used with meals or when eating certain foods because drug interactions can occur. Consuming alcohol or tobacco with certain drugs can also cause interactions to occur. Discuss your use of drugs with food, alcohol, or tobacco with your health care provider.

What health conditions can interfere with the performance of the drug Nafarelin?

Any other health conditions you have can affect the use of this drug. Always tell your doctor if you have other health problems, especially:

• Abnormal or unusual vaginal bleeding - Should not be used in patients with such conditions.
• Alcohol abuse
• Cigar smoking
• Conditions that increase the likelihood of bone thinning
• Osteoporosis (brittle bones) or a history of osteoporosis - Increases the risk of developing osteoporosis
• Ovarian cysts
• Pituitary gland problems
• Rhinitis (swollen or irritated nose) - Use with caution. Maybe it can make the condition worse

Dose

The information provided is not a substitute for a doctor's prescription. ALWAYS consult your doctor or pharmacist before starting treatment.

What is the dosage of Nafarelin for adults?

Usual Adult Dose for Endometriosis

200 micrograms intranasals daily. This can be achieved by one spray (200 micrograms) into one nostril in the morning and one spray into the other nostril at night. Treatment should be started between day 2 and 4 of the menstrual cycle. In certain patients, a daily dose of 400 micrograms may not produce amenorrhea. For patients with persistent menstruation after 2 months of treatment, the dose can be increased to 800 micrograms daily given as one spray into each nostril in the morning (two sprays total) and again in the evening. The recommended duration of treatment is six months. Re-treatment is not recommended because safety data are not available.

What is the dosage of the drug Nafarelin for children?

Usual Children's Dose for Early Puberty

800 micrograms intranasals twice daily. This can be achieved by two sprays (400 micrograms) into one nostril and two sprays into the other nostril twice daily.

If adequate suppression cannot be achieved, the dose may be increased to 1,800 micrograms intranasally per day given as 3 sprays (600 micrograms total) into the nostrils three times daily.

In what dosages and preparations is Nafarelin available?

Solution, Nasal: 2 mg / mL

What to do in an emergency or overdose?

In case of an emergency or overdose, contact the local emergency services provider (119) or immediately to the nearest hospital emergency department.

What should I do if I forget to take medicine or forget to take medicine?

If you forget a dose of this medicine, take it as soon as possible. However, when it is nearing the time of the next dose, skip the missed dose and return to the usual dosing schedule. Don't double the dose.

If you miss a dose, you may experience menstrual bleeding. Don't worry, but call your doctor.

Hello Health Group does not provide medical consultation, diagnosis or treatment.