Juvisync: functions, dosage, side effects, how to use

Uses

What is the Juvisync drug for?

Juvisync is an oral drug that consists of a combination of two types of drugs, namely sitagliptin and simvastatin. Sitagliptin is an oral diabetes medication that is used to help type two diabetes patients control their blood sugar levels. Meanwhile, simvastatin is a drug that functions to reduce levels of bad cholesterol (LDL) and triglycerides, as well as increase levels of good cholesterol, aka HDL in the blood.

Sitagliptin in Juvisync works to control blood sugar by regulating the amount of insulin released, especially after eating. Treatment using Juvisync is usually reserved for patients with type two diabetes who also have high cholesterol levels. Although it is used to control blood sugar levels in patients with type two diabetes, this combination drug is not used to treat people with type one diabetes.

Juvisync is a drug that when taken in conjunction with a regular diet and exercise program for type two diabetes (people with diabetes) can prevent the risk of kidney damage, blindness, nerve problems, amputation, and sexual function problems that can arise due to poor blood sugar control. . Good blood sugar control can also reduce a person's risk of heart attack and stroke in people with type two diabetes.

What are the rules for drinking Juvisync?

Take Juvisync as directed by your doctor. Juvisync is an oral medication that is taken once a day at night. Take this drug completely with drinking water. Do not crush, chew, or split this drug.

Your doctor may prescribe a low dose of this drug at the start of treatment and increase it gradually to avoid the risk of side effects. Do not change the dose or stop medication even though you feel better without consulting your doctor. The dose given takes into account your health condition and your body's response to treatment.

Take this medicine regularly for the expected results. To make it easier for you to remember, take this medication at the same time every day.

What are the Juvisync retention rules?

Store Juvisync at room temperature between 15-30 degrees Celsius. If you're not using it, keep it in the bottle and close it tightly. Keep away from places exposed to heat and direct sunlight. Do not store this medication in a damp place, such as a bathroom.

Do not flush this medication down the toilet or flush it down the drain unless instructed to do so. Discard this product if it has reached its expiration date or is no longer used. Consult your pharmacist or local waste disposal company regarding the proper way to dispose of this product.

Dose

The information provided is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist before starting treatment.

What is the dosage of Juvisync (sitagliptin-simvastatin) for adult patients?

Initial dose: 100 mg / 40 mg, once daily

For patients currently taking simvastatin: start with 50 mg or 100 mg sitagliptin plus the same dose of simvastatin that is currently being consumed.

What is the dosage of Juvisync (sitagliptin-simvastatin) for pediatric patients?

The use of Juvisync is not recommended for children younger than 18 years.

In what dosage and preparation is Juvisync available?

Tablet, Oral: 100 mg / 10 mg; 100 mg / 20 mg; 100 mg / 40 mg; 50 mg / 10 mg; 50 mg / 20 mg; 50 mg / 40 mg

Side effects

What side effects may occur due to consumption of Juvisync?

Basically, almost all drugs have side effects that may have serious consequences. However, most of these drugs do not produce serious side effects except in rare circumstances.

One possible side effect is an allergic drug reaction. Although clinical trials show this is rare, contact your doctor as soon as you notice signs of a serious allergic reaction in you after taking Juvisync, such as itching, rash, redness, blistering, swelling of the face / eyes / lips / tongue / throat area. , as well as difficulty breathing.

Some of the other side effects that may occur are:

• Confusion, memory problems
• Swelling, weight gain, less or no urination
• Pain in the upper abdomen that radiates to the back, nausea, vomiting, loss of appetite, and fast heartbeat
• Excessive thirst, urinating more frequently, hunger, dry mouth, drowsiness, dry skin, blurred vision, weight loss
• Itching, dark colored urine, pale stools, jaundice (visible on the eyes and skin)
• Sensitive skin reactions, such as fever, sore throat, swelling of the face and tongue, hot eyes, blisters accompanied by a reddish or purplish rash (especially on the face or upper body)

Other side effects are more common as a result of taking Juvisync:

• Flu symptoms, such as stuffy nose, sneezing and sore throat
• Headache
• Nausea and abdominal pain

In rare cases, this drug can cause conditions that result in damage to muscle tissue, which can lead to kidney failure. Call your doctor if you notice unexplained pain, stiffness, or weakness in your muscles, especially if you also have fever, unusual fatigue, and dark urine.

The above list is not a complete list of possible side effects. Talk to your doctor about possible side effects that concern you.

Warnings and Precautions

What should I know before taking Juvisync?

• Tell your doctor if you have an allergy to sitagliptin and / or simvastatin, along with other medicines. Juvisync medicine may contain other ingredients that can cause allergies
• Tell your doctor about your entire medical history, including any diseases you have or are currently suffering from, especially liver disease, acute kidney disease, diabetes ketoacidosis, thyroid gland disorders, pancreatitis, and gallstones.
• Tell your doctor if you are pregnant or planning a pregnancy
• Eating grapefruit or its juice is not recommended while undergoing treatment using Juvisync
• If you are going to have surgery, including dental surgery, tell your doctor / dentist about the use of all medicines that are currently being consumed, including Juvisync

Is Juvisync safe for pregnant and lactating women?

There has not been sufficient research conducted on pregnant and lactating women regarding the use of Juvisync and its risks to pregnancy. Always consult your doctor before taking this drug. According to the US Food and Drug Administration (FDA), the equivalent of the Indonesian Food and Drug Administration (Badan POM) in Indonesia, this drug is included in the risk of pregnancy category X (contraindicated).

Experiments conducted on animals have shown that sitagliptin is excreted by the body through breast milk, whereas it is not known for the simvastatin content in it. However, there are no known data for human breast milk. Nursing mothers are advised to stop treatment with Juvisync if they wish to breastfeed. Talk to your doctor about the available treatment alternatives.

Interaction

What drugs cause interactions with Juvisync?

The use of certain drugs at the same time may not be recommended because it will prevent one of the drugs from working properly and increase the risk of side effects. Even so, with a dose adjustment, several of these drugs can be prescribed simultaneously.

The following are some of the drugs that can cause interactions with Juvisync:

• Colchicine
• Fenofibric acid or fenofibrate
• Lomitapide
• Niacin (vitamin B3) in high doses
• Medicines to regulate heart rate, such as amiodarone or dronedarone
• Medicines for blood pressure, such as amlodipine, diltiazem, ranolazine, or verapamil

What foods and drinks give rise to interactions with Juvisync?

• Grapefruit and juice
• Alcohol
• High cholesterol foods (simvastatin in Juvisync will not work optimally if it is not balanced with a healthy diet)

Overdose

What should I do in an emergency or overdose?

Immediately call for emergency medical assistance (119) or the nearest hospital if you have an overdose of this drug. An overdose of this drug is usually accompanied by serious symptoms such as fainting and difficulty breathing.

What if I miss my medication schedule?

Take the missed dose as soon as you remember. If it is too close to the schedule for taking the next medication, ignore the missed dose. Drink Juvisync again on the schedule previously determined. Do not double your dose on a single medication schedule.