Jentadueto: functions, dosage, side effects, how to use

Jentadueto What medicine?

What is Jentadueto?

Jentadueto is an oral drug intended for diabetes patients. Consumption of Jentadueto coupled with a diet and exercise program can help control blood sugar in adult patients with type two diabetes. This medicine is not intended for the treatment of patients who have type one diabetes. Blood sugar control can help prevent the risk of kidney damage, blindness, nerve problems, amputations, or problems with sexual function. Proper blood sugar control also helps reduce the risk of heart attack and stroke.

Jentadueto is an oral drug made from a combination of two drug components, namely linagliptin and metformin. Linagliptin in Jentadueto works by increasing the body's natural substance called incretin. This incretin will later encourage the release of insulin into the blood, especially after eating to help control blood sugar.

Type two diabetics who experience insulin resistance have problems in their body responding to insulin, which results in disruption of the process of breaking down sugar from carbohydrates. The metformin in Jentadueto works by restoring your body's response to insulin, so that the metabolic process can run as it should. Metformin also lowers blood sugar levels by reducing the amount of sugar absorbed by the intestines during digestion so that glucose does not return to the bloodstream. The linagliptin and metformin contained in Jentadueto also play a role in lowering the amount of sugar produced by your liver.

What are the rules for drinking Jentadueto?

Take Jentadueto as directed by your doctor. Jentadueto is usually consumed twice a day at the same time as meals. When taking Jentadueto, make sure you are consuming enough water, unless your doctor recommends otherwise.

To reduce the risk of side effects, your doctor may give you a low dose first and then increase it gradually. The dose of this drug is given taking into account your health condition and your body's response to Jentadueto. Do not change your dose or stop medication without consulting your doctor.

Drink Jentadueto regularly for maximum results. To make it easier for you to remember, take this drug at the same time each day as your meal schedule. Follow the diet and exercise program recommended by your doctor.

What are the rules for saving Jentadueto?

This medication is best stored at room temperature. Avoid from light and do not store in damp places. Do not store this medication in the bathroom. Keep out of reach of children and pets.

Do not flush or flush this medication down the toilet or drain unless instructed to do so. Discard this product when it has reached its expiration date or is no longer in use. Consult your pharmacist or local waste disposal company about how to safely dispose of this medication.

Jentadueto dosage

The information provided is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist before starting treatment.

What is the dosage of Jentadueto (Linagliptin-Metformin) in adult patients?

Jentadueto immediate release tablet

• Initial dose for patients who have not taken metformin: linagliptin 2.5 mg / metformin 500 mg, twice daily
• Initial dose for patients taking metformin: linagliptin 2.5 mg combined with the same metformin dose, twice daily
• Initial dose for patients taking linagliptin and metformin in two separate tablets: switch to Jentadueto with the same dose of each component
• Maintenance dose: adjusted to the effectiveness and response of the patient's body
• Maximum daily dose: linagliptin 5 mg / metformin 2,000 mg

Jentadueto extended release (XR) tablet

• Initial dose for patients who have not taken metformin: linagliptin 5 mg / metformin (XR) 1,000 mg once daily
• Initial dose for patients taking metformin: linagliptin 5 mg combined with the same dose of metformin, once daily
• Initial dose for patients taking linagliptin and metformin in two separate tablets: switch to Jentadueto at the same dose for each component, once daily
• Dosage for patients switching from Jentadueto immediate release to Jentadueto (XR): 5 mg linagliptin and the same daily dose for metformin, once daily
• Maximum daily dose: linagliptin 5 mg / metformin 2,000 mg

What is the dosage of Jentadueto in pediatric patients?

The dosage in pediatric patients has not been established. The use of this drug is not recommended for patients younger than 18 years. Talk to your doctor about using the right medication for your child.

What is the dosage of Jentadueto in elderly patients?

Do not give this medicine to elderly people who are over 80 years of age without having had kidney function tests and stated normal.

In what dosage and dosage is Jentadueto available?

Tablet, Oral: 2.5 mg / 500 mg; 2.5 mg / 850 mg; 2.5 mg / 1,000 mg

Tablet (XR), Oral: 2.5 mg / 1,000 mg; 5 mg / 1,000 mg

Jentadueto side effects

What side effects arise from the consumption of Jentadueto?

Nausea, vomiting, stomach pain, diarrhea, or changes in taste (such as metal) in the mouth may occur as a side effect of taking Jentadueto. If these symptoms persist and even get worse, contact your doctor immediately. Symptoms of abdominal pain that occur at the start of treatment may be a sign of lactic acidosis. Tell your doctor if symptoms persist.

Tell your doctor if you have serious side effects, such as:

• Joint pain
• Injury to the skin without cause
• Signs of heart failure (shortness of breath, swelling in the feet or ankles, unusual fatigue, and sudden weight gain
• Signs of disease in the pancreas, such as nausea and vomiting that doesn't go away, pain in the gut that can radiate to the back

Other common side effects due to Jentadueto consumption are:

• Sore throat
• Sinusitis, nasal congestion

This medication can also cause hypoglycemia, especially if you consume large amounts of alcohol, do vigorous exercise, and do not consume enough calories. Symptoms can include cold sweat, body shaking, dizziness, drowsiness, fast heartbeat, fainting, tingling in the hands and feet, and hunger. Immediately consume food or drinks that can increase blood sugar levels quickly, such as sugar, honey, or candy.

Symptoms of hyperglycemia can also occur, such as excessive thirst, increased urination, confusion, drowsiness, flushed face, rapid breathing, and fruity breath. Tell your doctor if you experience this. You may need to increase the dosage.

Very serious allergic reactions from taking this medicine are known to occur rarely. Even so, immediately stop treatment and contact your doctor if you notice a serious allergic reaction, such as rash, redness, itching, swelling of the face / tongue / throat area, severe dizziness, and shortness of breath.

The above list is not a complete list of the possible side effects produced by Jentadueto. Talk to your doctor about the possible side effects that you are worried about will occur.

Jentadueto Drug Warnings and Cautions

What should I pay attention to before taking this drug?

• Tell your doctor if you have a drug allergy, especially to linagliptin and metformin, along with other drugs. Jentadueto may contain other ingredients which can also cause allergic reactions
• Before taking this medicine, inform your doctor about your medical history including past and current illnesses, especially if you have kidney problems, heart disease, liver disease, pancreatitis, gallstones, high levels of triglycerides in the blood.
• Before doing surgery or having an X-ray examination or scanning which requires you to use contrast fluid, inform your doctor about using Jentadueto
• This medicine may cause blurred vision, dizziness, or severe drowsiness as a result of a drastic drop or increase in blood sugar levels. Avoid activities that require high alertness, such as driving, before knowing how your body responds to this medication
• The metformin in Jentadueto can trigger ovulation even though you are already premenopausal and cause an unplanned pregnancy. Talk to your doctor if you are on a birth control program
• Tell your doctor if you plan to become pregnant or are pregnant but need to control blood sugar. Your doctor may prepare alternative treatments or make dosage adjustments

Is Jentadueto safe for pregnant and breastfeeding women?

There is no adequate data regarding the use of Jentadueto in pregnant and lactating women. The United States FDA classified this drug into category B, which is no risk in some studies. However, its use is not recommended during pregnancy, unless the benefits outweigh the possible risks to the fetus.

Metformin is known to be excreted with breast milk, while it is not known whether linagliptin is also passed out through breast milk. Nursing mothers are recommended not to take this drug.

Jentadueto Drug Interactions

What medicines may interact with Jentadueto?

Drug interactions can change the performance of your medications or increase the risk of serious side effects. Not all possible drug interactions are listed below.

Keep a list of all medications you have used or are currently using (including prescription, over-the-counter medicines, vitamins, and herbal products). Consult your doctor or pharmacist. The following is a list of drugs that may interact with Jentadueto:

• Acetazolamide
• Albiglutide
• Amlodipine
• Apalutamide
• Benazepril
• Contrast fluid
• Captopril
• Cimetidine
• Ciprofloxacin
• Dulaglutide
• Artificial conjugated estrogens
• Ethanol
• glipizide
• Ioversol
• Rifampin

Jentadueto overdose

What should I do if I have an emergency or overdose?

Jentadueto overdose can cause lactic acidosis. Call emergency medical help (119) or rush to the nearest hospital emergency department for help if someone experiences serious overdose symptoms such as fainting and difficulty breathing. Some of the other symptoms of overdose are:

• Great drowsiness
• Nausea, vomiting, or severe diarrhea
• Breathe fast
• Irregular heartbeat

What if I forget my medication schedule?

Take the missed dose as soon as you remember. However, if the distance is too close to the next schedule, skip the forgotten schedule. Continue taking medication on a regular schedule. Do not double your dose on a single medication schedule.