Factor viii: function, dose, side effects, how to use

Factor Viii What Medicine?

What is factor viii for?

This medication is used to control and prevent bleeding that occurs in people (usually men) with an inherited medical condition, hemophilia A (low levels of factor VIII). This medicine is also given before surgery to prevent bleeding too much in people with this condition. Factor VIII is a protein (clotting factor) that is present in normal blood, and helps blood clots form and stop bleeding after injury. People with low factor VIII levels may bleed longer than normal people after injury / surgery and may experience internal bleeding (especially in joints and muscles). This drug contains human-made factor VIII (antihemophilic factor) to temporarily replace factor VIII in the body, linked to antibodies (immunoglobulins) that help man-made factor VIII work longer. When used to control and prevent bleeding, this medication can help relieve pain and long-term damage caused by hemophilia A.

This medicine should not be used to treat von Willebrand's disease.

How is the factor viii used?

This medication is given by injection into a vein as directed by your doctor, usually no faster than 10 milliliters per minute. The timing of the injection may vary depending on your dose and how your body responds to it.

After the first time receiving this medication in a clinic or hospital, some people may be able to give this medication for themselves at home. If your doctor directs you to use this medication at home, read and study all of the preparations and uses in the instructions on the product package. Learn how to store and dispose of medical supplies safely. If you have questions, ask a health professional.

If the medicine and solution used for the mixture have cooled down, remove it from the refrigerator and allow it to take some time for it to reach room temperature before mixing. After mixing, stir gently to dissolve completely. Don't shake it. Before using this medication, visually inspect it for particles or discoloration. If there are any irregularities, do not use liquids. Use the medicinal mixture as soon as possible, but not more than 3 hours after mixing. Do not refrigerate the medicinal mixture.

Dosage is based on your medical condition, body weight, blood test results, and response to treatment. Children younger than 6 years of age may need higher doses. Follow the doctor's instructions carefully.

Tell your doctor if your condition does not improve or if it gets worse.

How is factor viii stored?

This medication is best stored at room temperature, away from direct light and damp places. Don't keep it in the bathroom. Don't freeze it. Other brands of this drug may have different storage rules. Observe the storage instructions on the product package or ask your pharmacist. Keep all medicines away from children and pets.

Do not flush medicines down the toilet or down the drain unless instructed to do so. Discard this product when it has expired or when it is no longer needed. Consult your pharmacist or local waste disposal company about how to safely dispose of your product.

Dosage Factor Viii

The information provided is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist before starting treatment.

What is the dose of factor viii for adults?

Through blood vessels

Episodes of Treatment and Bleeding Prophylaxis in Patients With Hemophilia A.

Adults: Individual dose based on coagulation tests performed before treatment and periodically during treatment. Generally, 1 IU / kg will increase the circulating factor VIII rate by about 2 IU / dL. Dosage recommendations vary according to the preparation used. recommended dose: light-moderate bleeding (increased to 20-30% of normal): Usually in a single dose 10-15 units / kg; more serious bleeding or minor surgery (30-50% increase from normal): initial dose of 15-25 units / kg followed by 10-15 units / kg every 8-12 hours if needed; heavy bleeding or major surgery (increase to 80-100% of normal): usual starting dose of 40-50 units / kg followed by 20-25 units / kg every 8-12 hours. See individual product information for further dosage details.

Through blood vessels

Severe hemophilia A prophylaxis

Adults: 10-50 u / kg every 2-3 days, as needed.

What is the dose of factor viii for children?

Normal Dosage for Children with Hemophilia A.

Routine prophylaxis to prevent or reduce the frequency of bleeding:

Up to 16 years of age: 20 to 40 IU per kg daily (3 to 4 times a week). Alternatively, a quarterly dosing regimen targeted at maintaining a Factor VIII level greater than 1% may be used.

The dosage required to maintain therapeutic plasma levels is based on active bleeding episodes:

Although the individual dosage should match the patient's needs (body weight, bleeding severity, presence of inhibitors), the following general doses are recommended: Amount of Antihemophilic Factor IU required = (body weight (in kg) x desired increase in Factor VIII (% normal)) x 0.5

or

minor bleeding (superficial bleeding, initial bleeding, bleeding into the joint): The required therapeutic plasma level for Factor VIII activity is 20% to 40% of normal, repeated every 12 to 24 hours as needed until completion. (At least 1 day, depending on the severity of the bleeding episode.)

Moderate (bleeding into muscles, minor head trauma, bleeding into the oral cavity): The therapeutic plasma level required for Antihemophilic Factor VIII activity is 30% to 60% of normal, repeated every 12 to 24 hours for 3-4 days or until hemostasis local reached.

Major (gastrointestinal, intracranial, intra-abdominal or intrathoracic bleeding, fracture): The therapeutic plasma level required for Antihemophilic Factor VIII activity is 60% to 100% of normal, repeated every 8 to 24 hours until the bleeding is resolved, finished, or case of surgery, until adequate local hemostasis and wound healing are achieved.

In what dosage is factor viii available?

Factor VIII is provided in a single use kit (4 mL size, dry) which includes bottles containing a nominal 250, 500, 1000, 1500 or 2000 IU.

Side Effects Factor Viii

What side effects can be experienced due to factor viii?

Common side effects include sore throat, cough, runny nose; fever or chills; mild nausea, vomiting; unusual or unpleasant taste in your mouth; skin itching or rash; warmth, redness, itching, or tingling under your skin; joint pain or swelling; dizzy; headache; or swelling, a stinging sensation, or irritation where the injection was given.

Get emergency medical help if you have any of the following signs of an allergic reaction: hives; hard to breath; feeling dizzy, fainting; swelling of your face, lips, tongue, or throat.

Stop using recombinant antihemophilic factor and call your doctor right away if you have serious side effects such as:

• chest pain
• easy bruising, increased bleeding
• bleeding from the wound or where the drug was injected

Less serious side effects may include:

• sore throat, cough, runny nose
• fever or chills
• mild nausea, vomiting
• bad or unusual feeling in your mouth
• skin itching or rash
• a sensation of warmth, redness, itching, or tingling under your skin
• joint pain or swelling
• dizzy
• headache
• swelling, stinging sensation, or irritation where the injection was given

Not everyone experiences this side effect. There may be some side effects not listed above. If you have any concerns about side effects, please consult a doctor or pharmacist.

Drug Warnings and Cautions Viii

What should be known before using factor viii?

Before administering antihemophilic (human) factor, tell your doctor and pharmacist if you have had a reaction to an antihemophilic factor or if you are allergic to any medication. Tell your doctor and pharmacist what prescription and medication you are taking, especially aminocaproic acid (Amicar), anticoagulants ('blood thinners') such as warfarin (Coumadin), corticosteroids (eg prednisone), nonprescription cyclophosphamide (Cytoxan), cyclosporin (Neoral, Sandimmune) ), low molecular weight heparin or heparin (Lovenox, Normiflo), interferon alfa (Roferon-A, Intron), vincristine (Oncovin), vitamin K, and other vitamins.

Tell your doctor if you are pregnant, planning pregnancy, or breastfeeding. If you become pregnant while taking antihemophilic (human) factor, call your doctor.

If you are having surgery, including dental surgery, tell your doctor or dentist that you are taking antihemophilic (human) factors, before the operation or surgical procedure.
You must know the antihemophilic (human) factor is made from human plasma. There is a risk that the antihemophilic (human) factor may contain immunodeficiency virus (HIV) or viruses that can cause hepatitis. Talk with your doctor about the potential risks of taking this drug.

Is factor viii safe for pregnant and lactating women?

There are no adequate studies regarding the risks of using this drug in pregnant or nursing women. Always consult your doctor to weigh the potential benefits and risks before using this medication. This drug is included in the risk of pregnancy category C according to the US Food and Drug Administration (FDA).

The following references the pregnancy risk categories according to the FDA:

• A = No risk,
• B = not at risk in several studies,
• C = May be risky,
• D = There is positive evidence of risk,
• X = Contraindicated,
• N = Unknown

Studies in women show that this drug poses minimal risk to the baby when used during breastfeeding.

Drug Interaction Factor Viii

What drugs may interact with factor viii?

Drug interactions can change the performance of your medications or increase the risk of serious side effects. Not all possible drug interactions are listed in this document. Keep a list of all the products you use (including prescription / non-prescription drugs and herbal products) and consult your doctor or pharmacist. Do not start, stop, or change the dose of any medication without your doctor's approval.

Can food or alcohol interact with factor viii?

Certain drugs should not be used with meals or when eating certain foods because drug interactions can occur. Consuming alcohol or tobacco with certain drugs can also cause interactions to occur. Discuss your use of drugs with food, alcohol, or tobacco with your health care provider.

What health conditions can interact with factor viii?

Any other health conditions you have can affect the use of this drug. Always tell your doctor if you have other health problems, especially:

• blood clots or a history of medical problems caused by the clot - use blood with caution. This condition can increase the risk of blood clots
• may increase due to slower removal of the drug from the body

Overdose of Factor Viii

What should I do in an emergency or overdose?

In case of an emergency or overdose, contact the local emergency services provider (112) or immediately to the nearest hospital emergency department.

What should I do if I miss a dose?

If you forget a dose of this medicine, take it as soon as possible. However, when it is nearing the time of the next dose, skip the missed dose and return to the usual dosing schedule. Don't double the dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.