Dolasetron: functions, dosage, side effects, how to use

What Drug Dolacetron?

What is dolasetron for?

This drug is generally used alone or together with other drugs to prevent nausea and vomiting caused by cancer drug therapy (chemotherapy). These drugs belong to a class of drugs called 5-HT3 blockers and work by blocking one of the body's natural substances (serotonin) that causes vomiting.
This medicine should not be used to prevent nausea or vomiting after surgery because it has a risk of serious side effects. However, the injectable form of this drug can be used after surgery. Ask your doctor for more details.

How do I use dolasetron?

Take this medication 1 hour before cancer chemotherapy or hours before surgery, or follow as directed by your doctor. This medicine can be taken with or without food.

Dosage is based on your medical condition and response to therapy. The usual maximum dose is 100 milligrams. For children, dosage is also based on age and body weight. Take this medication exactly as directed for benefits. Don't drink more than recommended. Ask your doctor or pharmacist if you have any questions.
Tell your doctor if your condition doesn't improve or if it gets worse

How do I store dolasetron?

This medication is best stored at room temperature, away from direct light and damp places. Don't keep it in the bathroom. Don't freeze it. Other brands of this drug may have different storage rules. Observe the storage instructions on the product package or ask your pharmacist. Keep all medicines away from children and pets.

Do not flush medicines down the toilet or down the drain unless instructed to do so. Discard this product when it has expired or when it is no longer needed. Consult your pharmacist or local waste disposal company about how to safely dispose of your product.

Dolasetron dosage

The information provided is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist before starting treatment.

What is the dose of dolasetron for adults?

Adult dose for nausea / vomiting due to chemotherapy

100 mg given for prevention within one hour before chemotherapy.

Approved indications: For prevention of nausea and vomiting associated with emetogenic moderate cancer chemotherapy in adults and children 2 and older.

Usual adult dose for nausea / vomiting - postoperative

12.5 mg given by infusion 15 minutes before discontinuation of anesthesia or when nausea and vomiting occur
Approved indications: For the prevention or treatment of postoperative nausea and / or vomiting.

What is the dose of dolasetron for children?

Child dosage for nausea / vomiting - postoperatively

2 and above: 0.35 mg / kg (maximum: 12.5 mg) given by infusion 15 minutes before discontinuation of anesthesia or when vomiting and nausea occur.

Or, 1.2 mg / kg (maximum: 100 mg) orally 2 hours before surgery.

Approved indications: For prevention or treatment of postoperative nausea and / or vomiting in pediatric patients 2 years and older.

Child dosage for nausea / vomiting - chemotherapy

2 years and above:

1.8 mg / kg (maximum 100 mg) taken one hour before chemotherapy

Maximum dose: 100 mg

For children who cannot swallow tablets, the solution is to have injection drugs mixed into their drink. The mixture is stable for up to 2 hours at room temperature. However, because it is dose dependent on QT prolongation, intravenous solutions are contraindicated in both adult and pediatric patients.
Approved indications: For prevention of nausea and vomiting associated with emetogenic moderate cancer chemotherapy in pediatric patients 2 years and older.

In what dosage is dolasetron available?

Solution, Intravenous as a mesylate:

Anzemet: 20 mg / mL (0.625 mL, 5 mL, 25 mL)

Tablets, taken as a mesylate:

Anzemet: 50 mg, 100 mg

Dolasetron side effects

What side effects can be experienced due to dolasetron?

Common side effects include headache, constipation, fatigue, drowsiness, or dizziness.

Stop using this drug and seek medical help if you experience any of the following:

felt like passing out
slow heart rate, weak pulse, slow breathing
swelling in the hands or feet
headache with chest pain and severe dizziness, fainting, or pounding heartbeats
urinating less than usual or not at all

Less serious side effects may include:

mild headache
tired feeling, lightheadedness
diarrhea, constipation, stomach pain, loss of appetite
chills, chills, numbness or a tingling feeling
fever, sweating
rash or
joint or muscle pain

Not everyone experiences this side effect. There may be some side effects not listed above. If you have concerns about certain side effects, consult your doctor or pharmacist.

Dolasetron Drug Warnings and Cautions

What should be known before using dolasetron?

Before starting treatment, you should contact your doctor and pharmacist if you are allergic to any of the ingredients in this medicine, or to any other medicines. Ask the pharmacist or check the patient information brochure for a list of ingredients.

Tell your doctor and pharmacist about any prescription or nonprescription drugs you are taking along with any vitamins, nutritional supplements, and herbal products you are taking or want to take. Be sure to mention the following listed drugs: atenolol (Tenormin) cimetidine (Tagamet) diuretics ('water pills') medications for irregular heartbeats including flecainide (Tambocor), quinidine (Quinidex, Quinaglute, others), and verapamil (Calan, Isoptin, Verelan, in Tarka) and rifampin (Rifadin, Rimactane). Also tell your doctor if you have received or have received certain cancer chemotherapy drugs such as daunorubicin (Cerubidine, DaunoXome), doxorubicin (Adriamycin, Rubex), epirubicin (Ellence), idarubicin (Zevalin), mitoxantrone (Novantrone), or valrubicin. Your doctor may need to change the dose of your medication or watch it carefully to avoid side effects.

Tell your doctor if you or someone in your family is sick or has had QT syndrome (a condition that increases the risk of an irregular heartbeat that can cause fainting or sudden death), or other types of irregular heartbeat or heart rhythm problems. , or if you are sick or have had low blood levels of magnesium or potassium, a heart attack, congestive heart failure, or heart or kidney disease.
Tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while using this medicine, call your doctor.

Is dolasetron safe for pregnant and lactating women?

There are no adequate studies regarding the risks of using this drug in pregnant or nursing women. Always consult your doctor to weigh the potential benefits and risks before using this medication. This drug is included in the risk of pregnancy category B according to the US Food and Drug Administration (FDA).

The following references the pregnancy risk categories according to the FDA:

A = No risk,
B = not at risk in several studies,
C = May be risky,
D = There is positive evidence of risk,
X = Contraindicated,
N = Unknown

There is not yet sufficient information about the safety of using this medicine during pregnancy and breastfeeding. Always consult your doctor to weigh the potential benefits and risks before using this medication.

Dolacetron Drug Interactions

What medicines may interact with dolasetron?

Although there are certain drugs that should not be used together with this drug, in other cases two different drugs can be used together even if an interaction is possible. In this case, your doctor may want to change the dose, or take other precautions that may be needed. When you are taking this medicine, it is very important that your doctor and pharmacist know if you are currently taking any of the medicines that are listed below. The following interactions were selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medication with any of the following medicines is not recommended. :

Amifampridine
Apomorphine
Bepridil
Cisapride
Dronedarone
Levomethadyl
Mesoridazine
Pimozide
Piperaquine
Sparfloxacin
Thioridazine
Ziprasidone

Using this medication with any of the following medicines is not usually recommended, but may and may be necessary in some cases:

Acecainide
Ajmaline
Alfuzosin
Almotriptan
Amineptine
Amiodarone
Amisulpride
Amitriptyline
Amitriptylinoxide
Amoxapine
Amphetamine
Anagrelide
Aprindine
Aripiprazole
Arsenic Trioxide
Asenapine
Astemizole
Azimilide
Azithromycin
Bretylium
Brompheniramine
Buserelin
Buspirone
Carbamazepine
Chloral Hydrate
Chloroquine
Chlorpheniramine
Chlorpromazine
Ciprofloxacin
Citalopram
Clarithromycin
Clomipramine
Clozapine
Cocaine
Crizotinib
Cyclobenzaprine
Dabrafenib
Dasatinib
Delamanid
Desipramine
Deslorelin
Desvenlafaxine
Dextroamphetamine
Dextromethorphan
Dibenzepin
Disopyramide
Dofetilide
Domperidone
Doxepin
Droperidol
Duloxetine
Eletriptan
Enflurane
Erythromycin
Escitalopram
Fentanyl
Fingolimod
Flecainide
Fluconazole
Fluoxetine
Fluvoxamine
Foscarnet
Frovatriptan
Furazolidone
Gatifloxacin
Gemifloxacin
Gonadorelin
Goserelin
Granisetron
Halofantrine
Haloperidol
Halothane
Histrelin
Hydroquinidine
Hydroxytryptophan
Ibutilide
Iloperidone
Imipramine
Iproniazid
Isocarboxazid
Isoflurane
Isradipine
Ivabradine
Ketoconazole
Lacosamide
Lapatinib
Leuprolide
Levofloxacin
Levomilnacipran
Lidoflazine
Linezolid
Lithium
Lofepramine
Lopinavir
Lorcainide
Lorcaserin
Lumefantrine
Mefloquine
Melitracen
Meperidine
Methadone
Methylene Blue
Metronidazole
Mifepristone
Milnacipran
Mirtazapine
Moclobemide
Moxifloxacin
Nafarelin
Naratriptan
Nefazodone
Nialamide
Nilotinib
Norfloxacin
Nortriptyline
Octreotide
Ofloxacin
Ondansetron
Opipramol
Paliperidone
Paroxetine
Pazopanib
Pentamidine
Pentazocine
Perflutren Lipid Microsphere
Phenelzine
Pirmenol
Posaconazole
Prajmaline
Probucol
Procainamide
Procarbazine
Prochlorperazine
Promethazine
Propafenone
Protriptyline
Quetiapine
Quinidine
Quinine
Ranolazine
Rasagiline
Risperidone
Rizatriptan
Salmeterol
Saquinavir
Selegiline
Sematilide
Sertindole
Sertraline
Sevoflurane
Sibutramine
Sodium Phosphate
Sodium Phosphate, Dibasic
Sodium Phosphate, Monobasic
Solifenacin
Sorafenib
Sotalol
Spiramycin
St. John's Wort
Sulfamethoxazole
Sultopride
Sumatriptan
Sunitinib
Tapentadol
Tedisamil
Telavancin
Telithromycin
Terfenadine
Tetrabenazine
Tianeptine
Toremifene
Tramadol
Tranylcypromine
Trazodone
Trifluoperazine
Trimethoprim
Trimipramine
Triptorelin
Tryptophan
Valproic Acid
Vandetanib
Vardenafil
Vemurafenib
Venlafaxine
Vilanterol
Vilazodone
Vinflunine
Voriconazole
Vortioxetine
Zolmitriptan
Zotepine

Can food or alcohol interact with dolasetron?

Certain drugs should not be used with meals or when eating certain foods because drug interactions can occur. Consuming alcohol or tobacco with certain drugs can also cause interactions to occur. Discuss your use of drugs with food, alcohol, or tobacco with your health care provider.

What health conditions can interact with dolasetron?

Any other health conditions you have can affect the use of this drug. Always tell your doctor if you have other health problems, especially:

bradycardia (slow heart rate)
congestive heart failure
Kidney disease should be monitored with an electrocardiogram (EKG) while using this medicine
congenital long QT syndrome
heart block, without pacemaker - should not be used in patients with this condition
heart disease
heart rhythm problems (eg, atrial fibrillation, prolonged QT, PR, and QRS tubes) or
sinus syndrome (an abnormal type of heart rhythm) - use with caution. May increase the risk for worsening the condition.
hypokalemia (low levels of potassium in the blood)
hypomagnesemia (low magnesium in the blood) - should be treated before using this medicine.

Dolasetron overdose

What should I do in an emergency or overdose?

In case of an emergency or overdose, contact the local emergency services provider (112) or immediately to the nearest hospital emergency department. If you experience symptoms of hypoglycemia, follow the instructions your doctor gives you. Other symptoms of an overdose include the following:

lost consciousness
dizzy
unstable heart rhythm

What should I do if I miss a dose?

If you forget a dose of this medicine, take it as soon as possible. However, when it is nearing the time of the next dose, skip the missed dose and return to the usual dosing schedule. Don't double the dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.