Desmopressin: functions, dosage, side effects, how to use it

What drug Desmopressin?

What is desmopressin for?

Desmopressin is a drug used to control the amount of urine your kidneys produce. The amount of urine is usually controlled by a certain substance in the body called vasopressin.

In people with water diabetes (diabetes insipidus), head injury or brain surgery, the body is unable to produce enough vasopressin. Desmopressin is an artificial drug and is used to replace low vasopressin. This medicine functions to control thirst and urination, thereby preventing dehydration.

Desmopressin is a drug that is also used to control the urine that children pass at night while sleeping (wetting the bed). This medicine can reduce nighttime bedwetting in children.

Desmopressin dosage

How is Desmopressin taken?

Desmopressin is a drug that is generally used 2 to 3 times a day for the treatment of diabetes insipidus.

To treat bed-wetting, take this medication is usually taken once a day at bedtime. Children should limit drinking after dinner, especially 1 hour before taking desmopressin until the next day, or at least 8 hours after the drug is consumed. If your child gets up at night, limit the amount of water he drinks.

All patients taking Desmopressin, especially children and the elderly, should limit the fluids they drink. Consult your doctor for information. If you drink more fluids than directed, tell your doctor right away. (Read information on side effects and prevention).

The dosage is based on your health condition and response to treatment. Do not use desmopressin in excess or take it more often than recommended.

Take this drug regularly and if possible at the same time every time in order to get maximum benefits. Tell your doctor if your condition does not improve or if this medication is not working properly.

How is Desmopressin stored?

Desmopressin is best stored at room temperature, away from direct light and damp places. Don't keep it in the bathroom. Don't freeze it. Other brands of this drug may have different storage rules. Observe the storage instructions on the product package or ask your pharmacist. Keep all medicines away from children and pets.

Do not flush medicines down the toilet or down the drain unless instructed to do so. Discard this product when it has expired or when it is no longer needed. Consult your pharmacist or local waste disposal company about how to safely dispose of your product.

Desmopressin side effects

The information provided is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist before starting treatment.

What is the desmopressin dosage for adults?

1. Usual Adult Dose for Diabetes Insipidus

The starting dose of the drug desmopressin is 0.05 mg orally twice daily or 1 to 2 mcg IV twice daily or 1 to 2 mcg subcutaneously twice daily or 5 to 40 intranasal mcg sprays twice daily or 0.1-0.4. mL through the intranasal rhinal tube twice daily. The maximum dose depends on the patient's response (adequate sleep, not much urination). The distance between the morning and evening doses should be properly adjusted to control urination.

2. Adult dosage for treating hemophilia A.

The initial dose of desmopressin infusion (IV) is 0.3 mcg / kg once slowly over 15-30 minutes. For preoperative IV doses can be infused 30 minutes before schedule. Blood pressure and heart rate should be monitored while the drug is being infused. Re-dosing should be determined based on laboratory results and the patient's health condition.

Intranasal: 1 spray (1.5 mg / mL) into the nostril. Drug coagulation checks are recommended before performing any surgery. This drug should be consumed 2 hours before the operation is carried out.

3. Adult dosage for treating von Willebrand's disease

The initial dose of desmopressin infusion (IV) is 0.3 mcg / kg once slowly over 15-30 minutes. For preoperative IV doses can be infused 30 minutes before schedule. Blood pressure and heart rate should be monitored while the drug is being infused. Re-dosing should be determined based on laboratory results and the patient's health condition.

Intranasal: 1 spray (1.5 mg / mL) into the nostril. Drug coagulation checks are recommended before performing any surgery. This drug should be consumed 2 hours before the operation is carried out.

Nasal sprays should not be used to treat patients with von Willebrand's disease type IIB because platelet aggregation can occur.

What is the dosage of Desmopressin for children?

1. Children's dosage for treating Diabetes insipidus

(For babies aged 3 months to children aged 12 years)

The initial intranasal dose of desmopressin is 5 mcg / day once a day or divided into 2 doses. Dosage ranges from 5 to 30 mcg / day. The distance between the use of the drug in the morning and evening must be well adjusted to control the urine excreted.

The initial oral dose of desmopressin is 0.05 mg twice daily. The dosage ranges from 0.1-0.8 mg daily.

IV and subcutaneous: No definite dosage is available yet. Dosage for adults should not be given at this age; side effects such as hyponatremic seizures may occur. The dose must be reduced. The recommended starting dose is about 0.1 to 1 mcg in 1 or 2 divided doses. Start at the initial dose and increase as needed. Monitor and limit the amount of serum sodium and urine excreted.

(Children 12 years and over)

The initial intranasal dose of desmopressin is 5 to 40 mcg / day divided into 1-3 doses. The distance between the use of the drug in the morning and evening must be well adjusted to control the urine excreted.

The initial oral dose of desmopressin is 0.05 mg twice daily. The dosage range 0.1-1.2 mg is divided into 2 or 3 doses.

IV: 1 to 2 mcg twice daily

subcutaneous: 1 to 2 mcg twice daily

When this medicine is taken by children, the intake of fluids must be controlled to prevent the possibility of hyponatremia and fluid poisoning. The drug will work optimally depending on the response of the patient (adequate rest and not consuming melted seraca ciran).

2. Usual Children's Dose for Hemophilia A.

Infants aged 3 months and children:

IV: 0.3 mcg / kg once slowly over 15-30 minutes. For preoperative IV doses can be infused 30 minutes before schedule. Blood pressure and heart rate should be monitored while the drug is being infused. Re-dosing may be required.

Children over 12 years of IV administration: 0.3 mcg / kg once slowly over 15-30 minutes.

Intranasal:

The child weighs 50 kg or less, give 150 mcg or if more than 50 kg: 150 mcg, sprayed into the nostrils.

Drug coagulation checks are recommended before performing any surgery. This drug should be consumed 2 hours before the operation is carried out.

In what dosage is Desmopressin available?

Desmopressin is a drug that is available in the following dosages:

Solutions, injections, such as acetate

• DDAVP: 4 mcg / mL (1 mL, 10 mL)
• Generic Drugs: 4 mcg / mL (1 mL, 10 mL)

Solution, nasal, such as acetate

• DDAVP: 0.01% (5 mL)
• DDAVP Rhinal Tube: 0.01% (2.5 mL)
• Stimate: 1.5 mg / mL (2.5 mL)
• Generic: 0.01% (2.5 mL, 5 mL)

Tablets, Oral, as acetate

• DDAVP: 0.1 mg, 0.2 mg
• Generic: 0.1 mg, 0.2 mg

Desmopressin Drug Warnings and Cautions

What side effects can be experienced due to desmopressin?

Desmopressin is a drug that can cause side effects. Common side effects include headache, nausea, stomach upset, or flushing. DDAVP can rarely cause low levels of sodium in the blood, which can be serious and possibly life threatening.

Seek immediate medical help if you have symptoms of low blood sodium such as loss of appetite, nausea, vomiting, severe headache, muscle weakness / spasms / cramps, weight gain, unusual fatigue, severe drowsiness, mental or mood changes (confusion, hallucinations, irritability), loss of consciousness, seizures, or shortness of breath.

Seek immediate medical help if you experience any of the following signs of an allergic reaction: hives, difficulty breathing, swelling of the face, lips, tongue, or throat.

Stop using the drug and contact your doctor if you experience any of the following side effects, such as:

• nausea, vomiting, weakness, loss of appetite, headache, feeling restless or irritable, confusion, hallucinations, muscle pain and weakness, and seizures
• feeling like you might pass out
• swelling, weight gain
• high blood pressure (severe headache, blurred vision, ringing in the ears, feeling anxious, confusion, chest pain, shortness of breath, unstable heartbeat, and seizures).

The following side effects are normal:

• headache
• nausea, mild stomach pain
• diarrhea or
• the face turns warm, flushed, or amused

Not everyone experiences the following side effects. There may be some side effects not listed above. If you have concerns about certain side effects, consult your doctor or pharmacist.

Desmopressin Drug Interactions

What should be known before using desmopressin?

Before using Desmopressin, pay attention to the following:

• tell your doctor and pharmacist if you are allergic to desmopressin or any other medication.

• tell your doctor and pharmacist about any medications (prescription / non-prescription), vitamins, health supplements, and herbal products you are using or will be using. Be sure to mention the following drugs: amitriptyline, amoxapine, clomipramine (Anafranil), desipramine (Norpramin), doxepin (Sinequan), imipramine (Tofranil), nortriptyline (Aventyl, Pamelor), protriptyline (Vivactil), and trimipramine (Surmontil); aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen (Advil, Motrin) and naproxen (Aleve, Naprosyn); carbamazepine (Tegretol); chlorpromazine (Thorazine, Sonazine); chlorpropamide (Diabinese); clofibrate; demeclocycline (Declomycin); fludrocortisone; heparin; lamotrigine (Lamictal); lithium (Eskalith, Lithobid); narcotic (opiate) medicine for pain; oxybutynin (Ditropan); selective serotonin reuptake inhibitors (SSRIs) such as citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem), fluvoxamine, paroxetine (Paxil), and sertraline (Zoloft); and urea (Pytest). Your doctor may need to change the dose of your medication or monitor you carefully for side effects
• tell your doctor if you have or have had kidney disease or if your blood sodium levels are low. Your doctor may tell you not to take Desmopressin
• tell your doctor if you have high blood pressure, or any medical condition that makes you very thirsty, for example cystic fibrosis, or heart disease
• if you are taking Desmopressin to treat bedwet, tell your doctor if you have an infection, fever, vomiting, or diarrhea. if the weather is very hot; or if you plan to exercise more than usual. You may need to drink more fluids than usual in this situation. Drinking too much fluids while you are taking Desmopressin can be dangerous, so your doctor may advise you not to take Desmopressin temporarily.
• tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while using Desmopressin, contact your doctor.
• ask your doctor about the safe use of alcoholic beverages while you are taking Desmopressin.

Is desmopressin safe for pregnant and lactating women?

There are no adequate studies regarding the risks of using this drug in pregnant or breastfeeding women. Always consult your doctor to weigh the potential benefits and risks before using this medication. This drug is included in the risk of pregnancy category B according to the Food and Drug Administration (BPOM) in America.

Following are references to pregnancy risk categories according to the Food and Drug Administration (BPOM) in America

A = Not at risk,

B = not at risk in several studies,

C = May be risky,

D = There is positive evidence of risk,

X = Contraindicated,

N = Unknown

Desmopressin overdose

What medicines may interact with desmopressin?

Desmopressin is a drug that can interact with other drugs. Although certain drugs should not be used simultaneously, in other cases two different drugs can be used together even if interactions are possible. In this case, your doctor may want to change the dose, or take other precautions that may be needed. Tell your health care professional if you are taking prescription drugs or nonprescription drugs as well as drugs on the market.

Can food or alcohol interact with desmopressin?

Desmopressin is a drug that can cause a reaction if you eat certain foods or drink alcohol. Certain drugs should not be used with meals or when eating certain foods because drug interactions can occur. Consuming alcohol or tobacco with certain drugs can also cause interactions to occur. Discuss your use of drugs with food, alcohol, or tobacco with your health care provider.

What health conditions can interact with desmopressin?

The presence of other health problems in your body may affect the use of this drug. Tell your doctor if you have other health problems:

• coronary artery disease
• cystic fibrosis
• kidney problems
• polydipsia (excessive thirst), habitual or psychogenic. Use with care. May cause side effects to be worse
• hypertension (high blood pressure). Use with care. Can make this condition worse
• hyponatremia (low sodium in the blood), or history
• kidney disease, moderate to severe. Should not be used in patients with this condition

Overdose

What should I do in an emergency or overdose?

In case of an emergency or overdose, contact the local emergency services provider (112) or immediately to the nearest hospital emergency department.

The following are symptoms of an overdose:

• • confusion
  • drowsiness
  • headache
  • difficulty urinating
  • weight increases suddenly

What should I do if I miss a dose?

If you forget a dose of this medicine, take it as soon as possible. However, when it is nearing the time of the next dose, skip the missed dose and return to the usual dosing schedule. Don't double the dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.