Deferoxamine: functions, dosage, side effects, how to use

What Drug Deferoxamine?

What is deferoxamine for?

Deferoxamine is a drug commonly used to treat excess levels of iron in the blood, which can be caused by repeated blood transfusions, blood disorders such as thalassemia, or iron poisoning.

Deferoxamine is a drug that can also be used to remove iron in patients with high iron levels, due to the large number of blood transfusions.

Deferoxamine belongs to a class of drugs iron chelators. Deferoxamine is a drug that works by binding to excess iron in the body and helping the kidneys and gallbladder remove excess iron.

This medicine is not recommended in children under 3 years of age. It can also be used to treat high aluminum levels in dialysis patients and patients with aluminum poisoning.

Rules of Use Deferoxamine

How do I use deferoxamine?

Follow the rules given by your doctor or pharmacist before starting treatment. If you have any questions, consult your doctor or pharmacist.

Depending on your medical condition, Deferoxamine will be injected directly into a muscle, under the skin or into a vein according to your doctor's instructions.

The dosage is based on your medical condition and response to treatment.

If you are using Deferoxamine at home, learn about its use from your medical provider. Before using, check if there are particles or discoloration of the product, do not use. Learn how to store and dispose of medicines safely.

If you are taking this drug to treat high iron levels, your doctor will recommend taking vitamin C (ascorbic acid) after you have taken this drug for 1 month. Taking vitamin C can replace vitamin C lost due to high iron levels and help medications to get rid of iron. If you have heart disease (such as heart failure), tell your doctor before taking vitamin C with this medicine (see Interactions section). Adults are recommended not to take more than 200 milligrams of vitamin C per day.

Tell your doctor if your condition does not improve or if it gets worse.

How is deferoxamine stored?

This medication is best stored at room temperature, away from direct light and damp places. Don't keep it in the bathroom. Don't freeze it. Other brands of this drug may have different storage rules. Observe the storage instructions on the product package or ask your pharmacist. Keep all medicines away from children and pets.

Do not flush medicines down the toilet or down the drain unless instructed to do so. Discard this product when it has expired or when it is no longer needed. Consult your pharmacist or local waste disposal company about how to safely dispose of your product.

Deferoxamine dosage

The information provided is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist before starting treatment.

What is the dosage for deferoxamine for adults?

The usual adult dosage for acute iron poisoning is

For the treatment of acute iron poisoning:

The initial dose is 15 mg / kg / hour by slow intravenous, the dose is reduced after 4-6 hours so that the dose does not exceed 80 mg / kg in 24 hours. It can also be given as a single dose of 2 grams by intramuscular injection

General geriatric dosage for acute iron poisoning

Determination of the dosage for elderly patients should be done carefully, usually starting from a low dose, considering the high frequency of decreased liver, kidney or heart function, other diseases and other therapies.

General geriatric dosage for chronic iron poisoning

Determination of the dosage for elderly patients should be done carefully, usually starting from a low dose, considering the high frequency of decreased liver, kidney or heart function, other diseases and other therapies.

What is the dosage of deferoxamine for children?

Common pediatric dosage for acute iron poisoning

This medicine can be dangerous for children. It is important to understand the safety of drugs before use. Consult your doctor or pharmacist for more information.

In what dosage is deferoxamine available?

Deferoxamine is a drug that is available in solution and injection doses of 500 mg and 2 grams.

Deferoxamine side effects

What side effects can be experienced due to deferoxamine?

Deferoxamine is a drug that can cause side effects. Common side effects include pain and swelling at the injection site or blurred vision.

Seek immediate medical help if you experience any of the following signs of an allergic reaction: hives, difficulty breathing, swelling of the face, lips, tongue, or throat.

Stop using Deferoxamine and contact your doctor immediately if you experience serious side effects such as:

• cough, shortness of breath or other breathing problems
• urinating infrequently or not at all
• drowsiness, dizziness, mood changes, increased thirst, loss of appetite, nausea and vomiting
• swelling, weight gain, shortness of breath
• nausea, pain in the upper stomach, itching, loss of appetite, cloudy urine, dark colored stools, jaundice
• hearing problems
• blurred vision, eye pain, or seeing circles in light
• convulsions (convulsions)
• the heart beats fast
• bluish lips, skin, nails
• severe, watery and bloody diarrhea with cramping
• nasal congestion, fever, redness or swelling around the nose and eyes, ulcers on the inside of the nose
• pain in the stomach or back, coughing up blood
• easy bruising or bleeding, weakness
• leg cramps, bone problems or growth changes (in children)

Less serious side effects that can include the use of deferoxamine are:

• dizzy
• flushing (warmth, redness and tingling feeling on the face)
• itching or rash on the skin
• numbness or burning in the body
• mild diarrhea, nausea or stomach pain
• reddish urine
• there is pain, stinging, swelling, redness, irritation or a hard lump at the injection site.

Not everyone experiences the following side effects. There may be some side effects not listed above. If you have concerns about certain side effects, consult your doctor or pharmacist.

Deferoxamine Drug Warnings and Cautions

What should be known before using deferoxamine?

Deferoxamine is a drug whose use must be under the supervision of a doctor. You are prohibited from using this medicine if you are allergic to Deferoxamine, have severe kidney disease or if you are unable to urinate. To make sure you can take Deferoxamine, tell your doctor if you have any of the following conditions

• kidney disease (or are on dialysis)
• heart disease
• liver disease
• vision or hearing problems
• asthma or respiratory disorders
• low calcium levels in the blood (hypocalcemia)
• parathyroid disorders.

If you need to have an X-ray or CT scan using a dye that is injected into a vein, you will need to stop using Deferoxamine. Make sure your doctor knows if you are using this drug.

Children

Deferoxamine is a drug whose long-term use can inhibit a child's growth. Tell the doctor if a child using this medicine does not grow properly.

Is deferoxamine safe for pregnant and lactating women?

Deferoxamine is a drug for which adequate research has not been found regarding the risks of using this drug in pregnant or breastfeeding women. Always consult your doctor to weigh the potential benefits and risks before using this medication. This drug is included in the risk of pregnancy category C according to the Food and Drug Administration (BPOM) in America.

Following are references to pregnancy risk categories according to the Food and Drug Administration (BPOM) in America:

• A = Not at risk,
• B = not at risk in several studies,
• C = May be risky,
• D = There is positive evidence of risk,
• X = Contraindicated,
• N = Unknown

It is not known whether Deferoxamine can harm a future baby. Tell your doctor if you are or plan to become pregnant while using this medicine.

It is not known whether Deferoxamine passes into breast milk or can harm a breastfed baby. Do not use this medication without telling your doctor that you are breastfeeding.

Deferoxamine Drug Interactions

What medicines may interact with deferoxamine?

Deferoxamine is a drug that can cause side effects. Drug interactions can change the performance of your medications or increase the risk of serious side effects. Not all possible drug interactions are listed in this document.

Keep a list of all the products you use (including prescription / non-prescription drugs and herbal products) and consult your doctor or pharmacist. Do not start, stop, or change the dose of any medication without your doctor's approval.

Using this medication with some of the medicines below is not usually recommended, but in some cases it may be necessary. If both drugs are prescribed for you, your doctor will usually change the dosage or determine how often you should take them

Can food or alcohol interact with deferoxamine?

Deferoxamine is a drug that can interact with certain health conditions. Certain drugs should not be used with meals or when eating certain foods because drug interactions can occur. Consuming alcohol or tobacco with certain drugs can also cause interactions to occur. Discuss your use of drugs with food, alcohol, or tobacco with your health care provider.

What health conditions may interact with deferoxamine?

Any other health conditions you have can affect the use of this drug. Always tell your doctor if you have other health problems, especially:

• excess aluminum
• dialysis treatment
• encephalopathy (brain disease), related to aluminum — May increase the risk of serious side effects
• anuria (unable to produce urine)
• severe kidney disease — Should not be used in patients with this condition.
• kidney problems
• convulsions, or have a history of seizures — Use with caution. May worsen the condition.
• infections (bacterial, fungal) —May decrease the body's ability to fight infection.

Overdose

What should I do in an emergency or overdose?

In case of an emergency or overdose, contact the local emergency services provider (112) or immediately to the nearest hospital emergency department.

What should I do if I miss a dose?

Deferoxamine is used only when needed and there is no specific schedule. Contact your doctor immediately if symptoms do not improve after taking Deferoxamine.

If you forget a dose of this medicine, take it as soon as possible. However, when it is nearing the time of the next dose, skip the missed dose and return to the usual dosing schedule. Don't double the dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.