Table of contents:
- What drug Deferasirox?
- What is deferasirox for?
- How do you use deferasirox?
- How do I store deferasirox?
- Deferasirox dosage
- What is the dosage for deferasirox for adults?
- What is the dosage of deferasirox for children?
- In what dosage is deferasirox available?
- Deferasirox side effects
- What side effects can be experienced due to deferasirox?
- Deferasirox Drug Warnings and Cautions
- What should be known before using deferasirox?
- Is deferasirox safe for pregnant and lactating women?
- Deferasirox Drug Interactions
- What medicines may interact with deferasirox?
- Can food or alcohol interact with deferasirox?
- What health conditions can interact with deferasirox?
- Deferasirox overdose
- What should I do in an emergency or overdose?
- What should I do if I miss a dose?
What drug Deferasirox?
What is deferasirox for?
Deferasirox is a drug used to treat high iron levels in the body caused by repeated blood transfusions. Deferasirox can also treat high iron levels in patients with blood disorders that do not require blood transfusions such as thalassemia (non-transfusion dependent thalassemia).
Blood transfusions are often required for several types of blood disorders, such as sickle cell disease and anemia. Blood transfusions have several benefits, but they can cause the body to store too much iron.
In patients who receive multiple blood transfusions and patients with non-transfusion dependent thalassemia but have high iron levels, excess iron can build up in multiple organs. This triggers various problems such as heart failure, liver disease and diabetes. These risks can be reduced by removing excess iron.
Deferasirox is a drug class of iron chelating agents. These drugs work by attaching to iron and helping the body remove excess iron through urine or feces.
How do you use deferasirox?
Take this medication on an empty stomach, at least 30 minutes before meals, usually once daily or as directed by your doctor. Do not chew or swallow the tablet immediately. Always dissolve the tablet as directed.
Some antacids that contain aluminum can decrease the amount of the drug that the body can absorb. If you are taking an antacid, wait until at least 2 hours after taking this medicine.
Take this medicine regularly to get optimal benefits. To help you remember, take this medication at the same time each day. Do not stop using this medication before consulting a doctor.
How do I store deferasirox?
Deferasirox is a drug that should be stored at room temperature, away from direct light and damp places. Don't keep it in the bathroom. Don't freeze it. Other brands of this drug may have different storage rules. Observe the storage instructions on the product package or ask your pharmacist. Keep all medicines away from children and pets.
Do not flush medicines down the toilet or down the drain unless instructed to do so. Discard this product when it has expired or when it is no longer needed. Consult your pharmacist or local waste disposal company about how to safely dispose of your product.
Deferasirox dosage
The information provided is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist before starting treatment.
What is the dosage for deferasirox for adults?
- For iron overload, the dose of deferasirox is 20 mg / kg once daily with a maximum dose of 40 mg / kg / day.
- For iron overload in syndromes non-transfusion dependent thalassemia, the dose of deferasirox is 10 mg / kg orally once a day.
Calculate the dose (mg per kg per day) at the nearest tablet size.
What is the dosage of deferasirox for children?
- For iron overload in children, the dose of deferasirox is 20 mg / kg once daily with a maximum dose of 40 mg / kg / day.
- For iron overload in syndromes non-transfusion dependent thalassemia, the dose of deferasirox is 10 mg / kg orally once a day.
Calculate the dose (mg per kg per day) at the nearest tablet size.
In what dosage is deferasirox available?
Available dosages of deferasirox are water soluble tablets 125 mg, 250 mg, 500 mg
Deferasirox side effects
What side effects can be experienced due to deferasirox?
The mild side effects of deferasirox are:
- Nausea
- Gag
- Stomach ache
- Dizzy
- Headache
- Restless
- Difficulty sleeping (insomnia)
- Mild rash, discoloration of skin
- Cough
- Nasal congestion
Not everyone experiences the above side effects. There may be some side effects not listed above. If you have concerns about certain side effects, consult your doctor or pharmacist.
Deferasirox Drug Warnings and Cautions
What should be known before using deferasirox?
Before using certain drugs, consider the risks and benefits first. This is a decision you and your doctor will have to make. Some things that you should consider before taking deferasirox drugs are:
- Tell your doctor if you have any unusual or allergic reactions to this or any other medicine. Also tell your doctor if you have any other types of allergies such as to food, coloring, preservatives, or animal allergies. For over-the-counter products, read the labels on the packaging carefully.
- Tell your doctor and pharmacist what medicines, vitamins, supplements and herbal products you are currently using or will be using.
- If you are taking an antacid that contains aluminum such as Amphogel, Alternagel, Gaviscon, Maalox, or Mylanta, take it 2 hours before or after deferasirox.
- Tell your doctor if you have an infection, severe nausea, vomiting or are dehydrated. Also let me know if you have or are experiencing problems with hearing or vision.
- Tell your doctor if you are pregnant, plan to become pregnant or are breastfeeding. If you become pregnant while taking deferasirox, contact your doctor.
- You should understand that deferasirox can make you dizzy. Do not drive or operate machinery until you know how this medication affects you.
- Tell your doctor if you experience diarrhea or vomiting during treatment. If you experience these symptoms, drink plenty of fluids to avoid dehydration.
Is deferasirox safe for pregnant and lactating women?
There are no adequate studies regarding the risks of using this drug in pregnant or nursing women. Always consult your doctor to weigh the potential benefits and risks before using this medication. This drug is included in the risk of pregnancy category C according to the US Food and Drug Administration (FDA) of the United States, or the equivalent of the Indonesian Food and Drug Administration Agency in Indonesia.
The following references the pregnancy risk categories according to the FDA:
- A = Not at risk
- B = No risk in several studies
- C = May be risky
- D = There is positive evidence of risk
- X = Contraindicated
- N = Unknown
Deferasirox Drug Interactions
What medicines may interact with deferasirox?
Drug interactions can change the performance of your medications or increase the risk of serious side effects. Not all possible drug interactions are listed in this document. Keep a list of all the products you use (including prescription / non-prescription drugs and herbal products) and consult your doctor or pharmacist. Do not start, stop, or change the dose of any medication without your doctor's approval.
Although some drugs should not be taken at the same time, in other cases some drugs can also be used together even though interactions may occur. In such cases, the doctor may change the dose, or take other preventive measures as needed. Tell your doctor if you are taking any other over-the-counter or prescription drugs.
Using this medication with some of the medicines below is not usually recommended, but in some cases it may be necessary. If both drugs are prescribed for you, your doctor will usually change the dosage or determine how often you should take them.
- Amiodarone
- Chloroquine
- Clozapine
- Duloxetine
- Enzalutamide
- Ondansetron
- Paclitaxel
- Pimozide
- Propafenone
- Theophylline
- Warfarin
Taking Deferasirox with the drugs below may increase the risk of side effects, but in some cases, a combination of these two drugs may be the best treatment. If both drugs are prescribed for you, your doctor will usually change the dosage or determine how often you should take them.
- Cholestyramine
- Midazolam
- Repaglinide
- Rifampin
Can food or alcohol interact with deferasirox?
Certain drugs should not be used with meals or when eating certain foods because drug interactions can occur. Consuming alcohol or tobacco with certain drugs can also cause interactions to occur. Discuss your use of drugs with food, alcohol, or tobacco with your health care provider.
What health conditions can interact with deferasirox?
Any other health conditions you have can affect the use of this drug. Some of the health conditions that may interact with the drug deferasirox are:
- Blood disorders (agranulocytosis, anemia, neutropenia)
- Eye problems (cataracts, glaucoma)
- Hearing problems
- Kidney disease (Fanconi's syndrome)
- Gastric ulcer
- Bone marrow problems (myelodysplastic syndrome)
- advanced cancer
- Severe kidney disease
- Severe liver disease
- Thrombocytopenia (low platelets in the blood)
- Hepatitis
Deferasirox overdose
What should I do in an emergency or overdose?
In case of an emergency or overdose, contact the local emergency services provider (112) or immediately to the nearest hospital emergency department.
Symptoms of a deferasirox overdose are:
- Yellow skin or eyes
- Pain in the upper right side of the stomach
- Unusual bruising or bleeding
- Weak, lethargic and lackluster
- Loss of appetite
- Flu symptoms
- Diarrhea
What should I do if I miss a dose?
If you forget a dose of this medicine, take it as soon as possible. However, when it is nearing the time of the next dose, skip the missed dose and return to the usual dosing schedule. Don't double the dose.
Hello Health Group does not provide medical advice, diagnosis or treatment.
