Table of contents:
- What medicine is Dabigatran?
- What's dabigatran for?
- Dabigatran dosage
- How to use dabigatran?
- Dabigatran side effects
- What is the dose of dabigatran for adults?
- Dabigatran Drug Warnings and Cautions
- What side effects can be experienced due to dabigatran?
- Dabigatran Drug Interactions
- What should be known before using dabigatran?
- Is dabigatran safe for pregnant and lactating women?
- Dabigatran overdose
- What medicines may interact with dabigatran?
- Can food or alcohol interact with dabigatran?
- What health conditions can interact with dabigatran?
- Overdose
- What should I do in an emergency or overdose?
- What should I do if I miss a dose?
What medicine is Dabigatran?
What's dabigatran for?
Dabigatran is a medicine used to prevent strokes and dangerous blood blockages (for example in your legs or lungs) if you have a type of irregular heartbeat disease (atrial fibrillation). In people with atrial fibrillation, part of the heart doesn't work the way it should.
This can cause blood clots to form and increase the risk of stroke or heart attack. Dabigatran is a drug that is also used to treat blood clots in the veins of your legs (deep vein thrombosis) or lungs (pulmonary embolism) and to reduce the risk of them recurring.
Dabigatran is an anticoagulant that works by blocking certain substances (a blockage protein called thrombin) in your blood. This helps to keep blood flowing smoothly in your body.
Dabigatran is a drug that should not be used to prevent blood clots that form after replacement of an artificial heart valve. If you've had heart valve surgery, talk to your doctor about the best medication for you. Don't stop taking any medications, including dabigatran, without talking to your doctor first.
Important to note! This section lists uses for this drug that are not listed on approved labels, but may be prescribed by your healthcare professional. Use this medication for the conditions listed below only if it has been prescribed by your doctor and health care professional.
Dabigatran is a drug that can also be used to prevent blood clots in your legs or lungs after hip or knee replacement surgery.
Dabigatran dosage
How to use dabigatran?
Read the Medication Guide or Information Leaflet provided by your pharmacist before you start using dabigatran and each time you get a refill. If you have questions, ask your doctor or pharmacist.
Take this medication with or without food as directed by your doctor, usually twice daily. To prevent clots after hip or knee replacement surgery, use as directed by your doctor usually once a day. Avoid antacids within 24 hours of surgery, as dabigatran may not work well.
Swallow the capsule whole with a full glass of water (8 ounces / 240 milliliters). Do not crush, chew, or open a capsule. Doing so can release all of the drug at once, increasing the risk of side effects. Do not put this medication in a pill box or medicine box reminder. This medicine should be kept tightly closed in the original bottle (orblister package) to protect it from moisture. See also the Storage section for more important details.
The dosage is based on your medical condition, kidney function, response to treatment, and other medications that can be used. Be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).
Use this remedy regularly for the most benefit. To help you remember, use it at the same time every day.
It is important to use as directed. Do not increase your dose or take this medication more often than directed. Do not stop taking this medication without consulting your doctor.
Follow the rules given by your doctor or pharmacist before starting treatment. If you have any questions, consult your doctor or pharmacist.
How is Dabigatran stored?
Dabigatran is a medicine that is best stored at room temperature, away from direct light and damp places. Don't keep it in the bathroom. Don't freeze it. Other brands of this drug may have different storage rules.
Observe the storage instructions on the product package or ask your pharmacist. Keep all medicines away from children and pets.
Do not flush medicines down the toilet or down the drain unless instructed to do so. Discard this product when it has expired or when it is no longer needed. Consult your pharmacist or local waste disposal company about how to safely dispose of your product.
Dabigatran side effects
The information provided is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist before starting treatment.
What is the dose of dabigatran for adults?
- Usual Adult Dose for Deep Vein Thrombosis - Prophylaxis
Take a dose of 150 mg orally twice a day. Generally, anticoagulant levels do not need to be monitored with this medicine. However, if necessary, use aPTT or ECT, and not INR to monitor anticoagulant activity.
Dabigatran is a useful drug for reducing the risk of stroke and systemic embolism in patients with non-valvular atrial fibrillation; treatment of deep vein thrombosis and pulmonary embolism in patients who have been treated with parenteral anticoagulants for 5 to 10 days; reduced risk of recurrence of deep vein thrombosis and pulmonary embolism in previously treated patients.
- Usual Adult Dose for Thromboembolic Prevention in Atrial Fibrillation
Take 150 mg orally twice a day. generally, anticoagulant levels do not need to be monitored with this drug. However, if necessary, use aPTT or ECT, and not INR to monitor anticoagulant activity.
Reduced risk of stroke and systemic embolism in patients with non-valve atrial fibrillation; treatment of deep vein thrombosis and pulmonary embolism in patients who have been treated with parenteral anticoagulants for 5 to 10 days; reduced risk of recurrence of deep vein thrombosis and pulmonary embolism in previously treated patients.
- Kidney Dose Adjustment
To reduce the risk of stroke and systemic embolism in non-valve atrial fibrillation, use the following dosages:
-CrCl greater than 30 mL / minute: 150 mg orally twice a day
-CrCl 15 to 30 mL / minute: 75 mg orally twice a day
-CrCl less than 15 mL / minute: Recommended dosage cannot be provided.
- When given with dronedarone or systemic ketoconazole:
-CrCl 30 to 50 mL / minute: Dosage can be reduced to 75 mg twice daily.
- Concomitant use with P-gp inhibitors:
-CrCl 30 to 50 mL / min: No adjustment recommended
-CrCl less than 30 mL / minute: Avoid using aids
- For Treatment and Reduction of the Risk of Recurrence of Deep Venous Thrombosis and Pulmonary Embolism:
-CrCl greater than 30 mL / minute: 150 mg orally twice a day
- CrCl less than 30 mL / minute: Recommended dosages cannot be provided
- Concomitant use with P-gp inhibitors:
-CrCl less than 50 mL / minute: Avoid using aids
What is the dosage of Dabigatran for children?
Dabigatran is a drug for which there is no prescribed dosage of this drug for children. This medicine can be dangerous for children. It is important to understand the safety of drugs before use. Consult your doctor or pharmacist for more information.
In what dosage is Dabigatran available?
Dabigatran is a drug that is available in oral capsule dosages of 75 mg and 150 mg
Dabigatran Drug Warnings and Cautions
What side effects can be experienced due to dabigatran?
Dabigatran is a drug that can have side effects. Side effects can include bruising and minor bleeding, nausea, and stomach upset.
Get emergency medical help if you have signs of this allergic reaction: hives; hard to breath; swelling of the face, lips, tongue, or throat.
Stop using dabigatran and call your doctor if you have serious side effects such as:
- bleeding that doesn't stop
- weakness, a feeling like you might pass out
- easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red spots spots under your skin;
- blood in the urine or stool, the stool is black
- coughing up blood or vomiting that looks like coffee grounds
- urine that is pink or brown in color
- joint pain or swelling
- heavy menstrual bleeding.
Less serious side effects may include:
- stomach pain or irritability, indigestion, heartburn
- nausea, diarrhea or
- mild skin rash or hives.
Not everyone experiences this side effect. There may be some side effects not listed above. If you have concerns about certain side effects, consult your doctor or pharmacist.
Dabigatran Drug Interactions
What should be known before using dabigatran?
Before using dabigatran,
- tell your doctor and pharmacist if you are allergic to dabigatran, any other medication, or any of the ingredients in dabigatran capsules. Ask the pharmacist or see the Medication Guide for a list of ingredients
- tell your doctor and pharmacist about the prescription and nonprescription drugs, vitamins, nutritional supplements, and herbal products you are using or will be using. Be sure to mention the following: dronedarone (Multaq), ketoconazole (Nizoral), and rifampin (Rifadin, Rimactane, in Rifamate, in Rifater). Your doctor may need to change the dose of your medication or monitor you carefully for side effects. Your doctor may need to change the dose of your medication or monitor you carefully for side effects
- tell your doctor if you have had a valve in your heart replaced or if recent bruising or unusual bleeding has occurred. Your doctor will probably tell you not to use dabigatran
- call your doctor if you are 75 years of age or older; if you have or have had problems with bleeding, bleeding or ulcers in the stomach or intestines or kidney disease.
- call your doctor if you are or plan to become pregnant, or breastfeeding. If you become pregnant while taking dabigatran, call your doctor. Using dabigatran can increase your risk of experiencing heavy bleeding during labor
- tell the doctor if you are having surgery, including dental surgery, tell the doctor or dentist about using dabigatran.
Is dabigatran safe for pregnant and lactating women?
Dabigatran is a drug that is not necessarily safe for pregnant and lactating women. There are no adequate studies regarding the risks of using this drug in pregnant or nursing women.
Always consult your doctor to weigh the potential benefits and risks before using this medication. This drug is included in the risk of pregnancy category C according to the Food and Drug Administration (BPOM) in America
Following are references to pregnancy risk categories according to the Food and Drug Administration (BPOM) in America:
A = No risk,
B = not at risk in several studies,
C = May be risky,
D = There is positive evidence of risk,
X = Contraindicated,
N = Unknown
Dabigatran overdose
What medicines may interact with dabigatran?
Dabigatran is a drug that can interact with other drugs. Although certain drugs should not be used together, in other cases two different drugs can be used together even if interactions are possible.
In this case, your doctor may want to change the dose, or take other precautions that may be needed. When you are using this medicine it is important that your healthcare provider knows if you are currently taking any of the medicines that are listed below. The following interactions are selected on the basis of their potential significance and are not necessarily all inclusive.
Using this medication with any of the following medicines is not recommended. Your doctor may decide not to treat you with this drug or change some of the other medicines you take.
- Itraconazole
Using this medication with any of the following medicines is not usually recommended, but may be necessary in some cases. If the two drugs are prescribed together, your doctor may change the dose or how often you use one or both drugs.
- Abciximab
- Abiraterone Acetate
- Aceclofenac
- Acemetacin
- Acenocoumarol
- Alipogene Tiparvovec
- Alteplase, Recombinant
- Amiodarone
- Amtolmetin Guacil
- Anagrelide
- Anistreplase
- Apixaban
- Argatroban
- Aspirin
- Azithromycin
- Bivalirudin
- Bosutinib
- Bromfenac
- Bufexamac
- Captopril
- Carbamazepine
- Carvedilol
- Celecoxib
- Choline Salicylate
- Cilostazol
- Clarithromycin
- Clonixin
- Clopidogrel
- Cobicistat
- Collagenase, Clostridium histolyticum
- Conivaptan
- Cyclosporine
- Daclatasvir
- Dalteparin
- Danaparoid
- Desirudin
- Dexibuprofen
- Dexketoprofen
- Diclofenac
- Dislunisal
- Diltiazem
- Dipyridamole
- Dipyrone
- Doxorubicin
- Doxorubicin Hydrochloride Liposome
- Dronedarone
- Drotrecogin Alfa
- Eliglustat
- Enoxaparin
- Eptifibatide
- Erythromycin
- Etodolac
- Etofenamate
- Etoricoxib
- Felbinac
- Felodipine
- Fenofibrate
- Fenoprofen
- Fepradinol
- Feprazone
- Floctafenine
- Flufenamic Acid
- Fluoxetine
- Flurbiprofen
- Fondaparinux
- Fosphenytoin
- Dabigatran
- Ibuprofen
- Ibuprofen Lysine
- Indomethacin
- Ivacaftor
- Ketoconazole
- Ketoprofen
- Ketorolac
- Lepirudin
- Levomilnacipran
- Lomitapide
- Lopinavir
- Lornoxicam
- Loxoprofen
- Lumiracoxib
- Meclofenamate
- Mefenamic Acid
- Meloxicam
- Morniflumate
- Nabumetone
- Naproxen
- Nepafenac
- Niflumic Acid
- Nilotinib
- Nimesulide
- Nintedanib
- Oxaprozin
- Oxyphenbutazone
- Parecoxib
- Pentosan Polysulfate Sodium
- Phenindione
- Phenobarbital
- Phenprocoumon
- Phenylbutazone
- Phenytoin
- Piketoprofen
- Piroxicam
- Pranoprofen
- Prasugrel
- Primidone
- Proglumetacin
- Propyphenazone
- Proquazone
- Protein C, Human
- Quercetin
- Quinidine
- Ranolazine
- Reteplase, Recombinant
- Rifampin
- Ritonavir
- Rivaroxaban
- Rofecoxib
- Salicylic Acid
- Salsalate
- Simeprevir
- Sodium Salicylate
- St. John's Wort
- Streptokinase
- Sulfinpyrazone
- Sulindac
- Sunitinib
- Telaprevir
- Tenecteplase
- Tenoxicam
- Tiaprofenic Acid
- Ticagrelor
- Ticlopidine
- Tinzaparin
- Tipranavir
- Tirofiban
- Tocophersolan
- Tolfenamic Acid
- Tolmetin
- Ulipristal
- Urokinase
- Valdecoxib
- Verapamil
- Vorapaxar
- Vortioxetine
- Warfarin
Can food or alcohol interact with dabigatran?
Certain drugs should not be used with meals or when eating certain foods because drug interactions can occur. Consuming alcohol or tobacco with certain drugs can also cause interactions to occur. Discuss your use of drugs with food, alcohol, or tobacco with your health care provider.
What health conditions can interact with dabigatran?
The presence of other health problems in your body may affect the use of this drug. Tell your doctor if you have other health problems .:
-
- bleeding, active
- cardiac (artificial) mechanical prosthetic valve - dabigatran should not be used in patients with this condition
- bleeding problems, history
- kidney problems
- stomach bleeding or sores or has recently had an increased risk of bleeding
- kidney disease - use needs to be monitored due to slow cleansing from the body
Overdose
What should I do in an emergency or overdose?
In case of an emergency or overdose, contact the local emergency services provider (112) or immediately to the nearest hospital emergency department.
Symptoms of overdose include:
- unusual bruising or bleeding
- urine that is pink or brown in color
- red or black stool,
- vomit that bleeds or looks like coffee grounds
- coughing up blood
What should I do if I miss a dose?
If you forget a dose of this medicine, take it as soon as possible. However, when it is nearing the time of the next dose, skip the missed dose and return to the usual dosing schedule. Don't double the dose.
Hello Health Group does not provide medical advice, diagnosis or treatment.
