Cladribine: functions, dosage, side effects, how to use it

What Drug Cladribine?

What is cladribine for?

Cladribine is a drug commonly used to treat certain types of cancer of hair cell leukemia or lymphoma. This drug works by stopping the growth of cancer cells. Use this drug as prescribed by your doctor.

How to use cladribine?

Cladribine is a type of drug that is given by injection into a vein. Cladribine dosage depends on your body weight and response to treatment. This medicine is usually given for 7 consecutive days or as directed by a doctor.

Keep the medicine away from the eyes, mouth or nose. If you get the drug in these areas, flush with plenty of water and tell your doctor right away.

How do I save cladribines?

Cladribine is a drug that is best stored in a cool place with a temperature of 2-8 degrees Celsius and away from light and moisture. Do not store this medication in the bathroom. Don't freeze it either. Other brands of this drug may have different storage rules. Observe the storage instructions on the product package or ask your pharmacist. Keep all medicines away from children and pets.

Do not flush medicines down the toilet or down the drain unless instructed to do so. Discard this product when it has expired or when it is no longer needed. Consult your pharmacist or local waste disposal agency about how to safely dispose of your product.

Cladribine dosage

The information provided is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist before starting treatment.

What is the cladribine dosage for adults?

For adults, the dose of cladribine is 0.09 mg / kg per day followed by infusion for 7 days.

What is the cladribine dosage for children?

The safety and effectiveness of this drug have not been confirmed in children under 18 years of age.

In what dosage is cladribine available?

The drug supply for cladribine is a 10 mg / 10 mL solution

Cladribine side effects

What side effects can be experienced due to cladribine?

The most common side effects of using the drug cladribine are:

• Headache
• The body is weak and powerless
• Nausea
• Gag
• Diarrhea
• Constipation
• Mild itching or skin rash
• Cough
• Pain, swelling, or irritation around the IV needle

Seek immediate medical help if you experience serious side effects such as:

• Numbness, tingling, or pain in the fingers or toes
• Feelings of passing out
• Redness, swelling, or itching under your skin
• Lower back pain, bloody urine, or not urinating less than usual
• Touching muscles
• Fast or slow heart rate, weak pulse, shortness of breath
• Pale or yellow skin, dark urine, fever, unfocused
• Easy bruising, unusual bleeding (on the nose, mouth, vagina, or rectum), purple or red spots under the skin
• Signs of infection such as fever, chills, sore throat, flu symptoms, cough with yellow or green mucus, loss of appetite, mouth sores, unusual fatigue

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about the side effects of cladribine, please consult your doctor or pharmacist.

Cladribine Drug Warnings and Cautions

What should be known before using cladribine?

Some things to consider before using cladribine are:

• Allergy.Tell your doctor if you have ever had any allergies to cladribine or other medications. Also tell your doctor if you have any other allergies such as allergies to foods, dyes, preservatives, or animals. For non-prescription drugs, read the label or ingredients carefully.
• Children. There is no clear information regarding the use of cladribine in children in any age group. Cladribine has been tested in children with various types of cancer.
• Elderly.Many drugs have not been studied specifically for the elderly. However, it is not expected that this drug will cause different side effects or problems in the elderly than it does in younger adults.

Is cladribine safe for pregnant and lactating women?

There are no adequate studies regarding the risks of using this drug in pregnant or breastfeeding women. Always consult your doctor to weigh the potential benefits and risks before using this medication. This drug is included in the risk of pregnancy category D according to the Food and Drug Administration (FDA) in the United States, which is equivalent to the POM in Indonesia.

The following references the pregnancy risk categories according to the FDA:

• A = Not at risk
• B = No risk in several studies
• C = Maybe risky
• D = There is positive evidence of risk
• X = Contraindicated
• N = Unknown

Cladribine Drug Interactions

What medicines may interact with cladribine?

Although some drugs should not be taken at the same time, in other cases some drugs can also be used together even though interactions may occur. In such cases, the doctor may change the dose, or take other preventive measures as needed. Tell your doctor if you are taking any other over-the-counter or prescription drugs.

Taking cladribine with Rotavirus Vaccine is not recommended. Your doctor may decide not to treat you with cladribine or change some of the other drugs you take.

Using cladribine with any of the medicines below is usually not recommended, but may be needed in some cases. If both drugs are prescribed together, your doctor may change the dose or change the frequency of time you are taking one or both of these drugs.

• Adenovirus Vaccine Type 4, Active
• Adenovirus Vaccine Type 7, Active
• Bacillus of Calmette and Guerin Vaccine, Active
• Cobicistat
• Influenza Virus Vaccine, Active
• Measles Virus Vaccine, Active
• Mumps Virus Vaccine, Active
• Rubella Virus Vaccine, Active
• Smallpox vaccine
• Typhoid Vaccine
• Varicella Virus Vaccine
• Yellow Fever Vaccine

Can food or alcohol interact with cladribine?

Certain drugs should not be used with meals or when eating certain foods because drug interactions can occur. Consuming alcohol or tobacco with certain drugs can also cause interactions to occur. Discuss your use of drugs with food, alcohol, or tobacco with your health care provider.

What health conditions can interact with cladribine?

Some of the health conditions that may interact with the drug cladribine are:

• Chicken pox
• Shingles (shingles)
• Kidney stones
• Certain infections

Cladribine overdose

What should I do in an emergency or overdose?

In case of an emergency or overdose, contact the local emergency services provider (112) or immediately to the nearest hospital emergency department.

Symptoms of a cladribine overdose are:

• Urinating less frequently
• Swelling of the face, arms, hands, feet, ankles
• Fatigue is not
• Unusual bleeding or bruising
• Black or bloody stools
• Vomited blood that looked like coffee grounds
• Fever, sore throat, chills, or other signs of infection
• Pain, numbness, or tingling in the hands or feet
• Weakness in the arms or legs
• Loss of ability to move arms or legs

What should I do if I miss a dose?

If you forget a dose of this medicine, take it as soon as possible. However, when it is near the time of the next dose, skip the missed dose and return to the usual dosing schedule. Don't double the dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.