Avandamet: functions, dosage, side effects, how to use it

What medicine is Avandamet?

What is Avandamet?

Avandamet is an oral drug consisting of a combination of two drugs, namely rosiglitazone and metformin. The use of Avandamet together with a diet and exercise program can help control blood sugar levels in patients with type two diabetes. Controlling high blood sugar can help prevent kidney damage, blindness, nerve problems, loss of limbs, and problems with sexual function. Good diabetes control can also help reduce your risk of having a heart attack and stroke.

Rosiglitazone and metformin contained in Avandamet lower blood sugar by restoring your body's response to insulin. Metformin also decreases sugar production by the liver and the amount of sugar absorbed by the intestines during digestion.

Avandamet is not intended to treat patients with type one diabetes. Avandamet is also not recommended for use with insulin. Using the two together increases your risk of serious heart problems.

What are the rules for taking Avandamet?

Avandamet is an oral medication that is usually taken once or twice a day with meals to avoid stomach upset. Often times, your doctor will give you a low dose first at the start of treatment and increase it gradually.

Do not change your dose, stop, or continue treatment if it is not recommended by your doctor. The dosage given is based on your health condition and your body's response to treatment.

Take this drug regularly to get maximum results. To make it easier for you to remember, take this medication at the same time each day.

What are the storage rules for Avandamet?

This medication is best stored at room temperature not exceeding 30 degrees Celsius. Avoid storing this drug from heat and direct light. Do not store this medication in a damp place, such as a bathroom. Keep out of reach of children and pets.

Do not flush or flush this medication down the toilet or drain unless instructed to do so. Discard this product if it has expired or is no longer needed. Ask your pharmacist or local waste disposal company about how to safely dispose of this product.

Avandamet dosage

The information provided is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist before starting treatment.

What is the dosage of Avandamet (rosiglitazone / metformin) for adult patients?

• Initial dose: rosiglitazone 2 mg / metformin 500 mg, once or twice daily
• If HbA1C is greater than 11% or fasting blood sugar exceeds 270 mg / dL, consider the initial dose of rosiglitazone 2 mg / metformin 500 mg, twice daily.
• Increase the dose of rosiglitazone to 2 mg / metformin 500 mg per day in divided doses if it remains uncontrolled after four weeks.

In patients who have taken rosiglitazone:

Initial dose: switch to Avandamet with the same dose of rosiglitazone plus metformin 1,000 mg per day, divided into two doses

In patients who have taken metformin:

Initial dose: switch to Avandamet with the same dose of metformin plus 4 mg of rosiglitazone per day, divided into two doses

In patients who have taken rosiglitazone and metformin as separate tablets:

Switch to Avandamet with the same dose of each composition

Maximum daily dose: rosiglitazone 8 mg / metformin 2,000 mg per day

In what dosage and preparation is Avandamet (rosiglitazone-metformin) available?

Tablet, Oral: 2 mg / 500 mg, 4 mg / 500 mg, 2 mg / 1,000 mg, 4 mg / 1,000 mg.

Avandamet side effects

What side effects may arise due to consumption of Avandamet?

Nausea, stomach pain, diarrhea, and a metallic sensation in your mouth may occur as a result of taking this drug in the early stages of treatment. If the complaints in your stomach do not go away, contact your doctor immediately. This could indicate lactic acidosis due to consuming too much metformin.

The serious side effects that may occur due to consumption of Avandamet are, as follows:

• Changes to your ability to see
• Feelings of floating, like going to fall
• Anemia, which is characterized by pale skin, a feeling of spinning in the head or shortness of breath, fast heartbeat, and difficulty concentrating
• Heart attack symptoms, chest pain or pressure, pain radiating to the jaw or shoulder, nausea, sweating
• Signs of heart failure, such as shortness of breath even when lying down, swelling in the legs or ankles, rapid weight gain
• Liver problems, which are characterized by nausea, vomiting, loss of appetite, pain in the upper abdomen, fatigue, dark urine, pale stools, jaundice (of the skin or eyes)
• A severe skin reaction, characterized by fever, sore throat, swelling of the face or tongue, hot eyes, sore on the skin surface accompanied by a reddish or purplish rash that spreads (especially on the face and upper body), sore skin and peel off

The more common side effects are:

• Headache, dizziness
• Joint pain

Severe allergic reactions are known to rarely occur as a result of using this drug. However, call your doctor immediately if you notice signs of an allergy such as rash, itching, swelling of the face, eyes, lips, tongue and throat, severe dizziness, and shortness of breath.

The list above does not include all the side effects that can occur due to consumption of Avandamet. Consult with your doctor about the possible side effects that you are worried about could occur before taking this medicine.

Avandamet Drug Warnings and Cautions

What should be considered before taking Avandamet?

• Inform your doctor about any history of drug allergies you have, especially if you are allergic to rosiglitazone and / or metformin, glitazone drugs, such as pioglitazone or other drug allergies.
• Tell your doctor about your medical history, including past or current illnesses, especially if you have kidney disease, liver disease, respiratory problems (lung disease or severe asthma), heart disease (heart failure, seizures). heart and angina), blood disorders (anemia or vitamin B12 deficiency), swelling (edema), fluid in the lungs, eye disorders, bone disorders (such as osteoporosis)
• Before performing surgery or an X-ray / CT Scan procedure that uses iodine contrast fluid, inform your doctor or dentist about the use of this medicine. You may need to stop taking this drug if you are going to have surgery (including dental surgery) in the near future
• Some people may experience lactic acidosis from taking metformin. Call your doctor if you find a condition that indicates symptoms of lactic acidosis such as stomach pain and nausea
• Avandamet use can encourage ovulation and menstruation in women, even if they have not had the cycle for a long time for health reasons. This leaves the chance that an unplanned pregnancy will occur. Consult your doctor about this if you are planning a birth
• Tell your doctor if you plan to become pregnant or are pregnant. Your doctor may suggest alternative treatments or adjust your dose depending on the trimester you are taking

Is Avandamet safe for pregnant and lactating women?

There has not been adequate research regarding the risks to the fetus in pregnant women who take Avandamet. However, animal studies suggest a risk to the fetus. The United States Food and Drug Administration (FDA) lists Avandamet as a category C (possibly risky) drug.

The metformin contained in Avandamet is known to come out together with breast milk, but it is not known whether the same thing happens to rosiglitazone. There are no studies showing that both can pose a risk to a newborn. It is recommended that you do not take this drug while breastfeeding. Consult with your doctor about solutions that can be taken.

Avandamet Drug Interactions

Drug interactions may change how your medications work or increase your risk of serious side effects. Some of the products that interact with Avandamet are:

• Insulin or other oral diabetes medication
• Medicines for heart disease or blood pressure control
• Cholesterol-lowering drugs

This list may not include all drugs or products that may interact with Avandamet. Keep a complete list of the drugs you take and keep them informed to your doctor, including prescription drugs, over-the-counter drugs, vitamins, and herbal medicines to prevent drug interactions.

Avandamet overdose

What should I do in an emergency or overdose?

Seek immediate medical emergency help by calling 119 or immediately to the nearest hospital emergency department. Serious symptoms that suggest an overdose include fainting and difficulty breathing.

What if I forget my medication schedule?

If you forget your scheduled medication, take it as soon as you remember. Skip the missed dose when you are close to your next schedule. Continue your dosage on a regular schedule. Do not double up on doses to make up for missed doses on one scheduled medication.

Hello Health Group does not provide medical advice, diagnosis or treatment.