Nilotinib: functions, dosage, side effects, how to use it

What Drug Nilotinib?

What is the drug Nilotinib used for?

Nilotinib is a drug to treat certain types of blood cancer (chronic myelogenous leukemia-CML). These drugs work by slowing or stopping the growth of cancer cells.

How do you use the drug Nilotinib?

Avoid eating grapefruit or drinking its juice while being treated with this medicine unless your doctor instructs you otherwise. Citrus fruits can increase the amount of certain drugs in your bloodstream. Consult your doctor or pharmacist for more details. Take this medication on an empty stomach, usually twice daily with a time interval of about 12 hours or as directed by your doctor. Swallow the capsule whole with water. Do not open, crush, or chew the capsules. Do not eat food for at least 2 hours before or for 1 hour after taking your dose. Taking this drug with food can increase the amount of medicine in your body and increase your risk of serious side effects. If you cannot swallow the capsules, they can be opened and the contents sprinkled in 1 teaspoon with applesauce. This mixture should be swallowed immediately (within 15 minutes). Use only 1 teaspoon of applesauce. Do not sprinkle the contents on other types of food.

Drink plenty of fluids during treatment with this medicine, unless directed by your doctor differently.

If you are also taking an antacid, use it 2 hours before or after using nilotinib. If you are also taking H2 blockers (such as cimetidine, famotidine), take them 10 hours before or 2 hours after nilotinib.

The dosage is based on your medical condition, response to treatment, laboratory tests, and other drugs you may be using. Be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Do not increase your dose or use this medication more often than prescribed. Your condition will not recover any sooner and the risk of serious side effects can be increased.

Because this medicine can be absorbed through the skin and lungs, women who are pregnant or who may become pregnant should not tamper with this medicine or inhale the powder from the contents of the capsule.

Follow the rules given by your doctor or pharmacist before starting treatment. If you have any questions, consult your doctor or pharmacist.

How to store Nilotinib?

This medication is best stored at room temperature, away from direct light and damp places. Don't keep it in the bathroom. Don't freeze it. Other brands of this drug may have different storage rules. Observe the storage instructions on the product package or ask your pharmacist. Keep all medicines away from children and pets.

Do not flush medicines down the toilet or down the drain unless instructed to do so. Discard this product when it has expired or when it is no longer needed. Consult your pharmacist or local waste disposal company about how to safely dispose of your product.

Nilotinib dosage

What should be considered before using the drug Nilotinib?

Before using Nilotinib,

• Tell your doctor and pharmacist if you are allergic to nilotinib or any other medications
• Tell your doctor and pharmacist about any prescription drugs, nonprescription drugs, vitamins, and nutritional supplements you are taking or planning to use. Be sure to mention the following drugs: certain angiotensin-receptor blockers such as irbesartan (Avapro) and losartan (Cozaar, in Hyzaar); anticoagulants ("blood thinners") such as warfarin (Coumadin); aripiprazole (Abilify); certain benzodiazepines such as alprazolam (Xanax), diazepam (Valium), midazolam, and triazolam (Halcion); buspirone (BuSpar); Certain calcium channel blockers such as amlodipine (Norvasc), diltiazem (Cardizem, Dilacor, Tiazac, and others), felodipine (Plendil), nicardipine (Cardene), nifedipine (Adalat, Procardia), nisoldipin (Sular), and verapamil (Calan, Isoptin) , Verelan); certain cholesterol-lowering drugs (statins) including atorvastatin (Lipitor), fluvastatin (Lescol), lovastatin (Mevacor), and simvastatin (Zocor); chlorpheniramine (Chlor-Trimeton, other cough and cold medicines); dexamethasone (Mymethasone); flecainid (Tambocor); certain depression medications such as amitriptyline, desipramine (Norpramin), duloxetine (Cymbalta), imipramine (Tofranil), paroxetine (Paxil), and venlafaxine (Effexor); certain oral medications for diabetes such as glipizide (Glucotrol) and tolbutamide; certain drugs that suppress the immune system such as cyclosporine (Neoral, Sandimmune) and tacrolimus (Prograf); certain medications for seizures such as carbamazepine (Equetro, Carbatrol, Tegretol), phenobarbital, and phenytoin (Dilantin, Phenytek); mexiletine; certain nonsteroidal anti-inflammatory drugs (NSAIDs) such as celecoxib (Celebrex), diclofenac (Voltaren), ibuprofen (Advil, Motrin), naproxen (Aleve, Naprosyn), and piroxicam (Felden); ondansetron (Zofran); propafenone (Rythmol); quinine (Qualaquin); rifabutin (Mycobutin); rifampin (Rifadin); rifapentine (Priftin); risperidone (Risperdal); sildenafil (Viagra, Revatio); tamoxifen; testosterone (Androderm, AndroGel, Striant, others); timolol; torsemide; tramadol (Ultram, on Ultracet); trazodone; and vincristine. Your doctor may need to change the dose of your medication or watch you carefully for side effects. Many other medicines can also interact with nilotinib, so be sure to tell your doctor about all drugs you use, even those that don't appear on this list.
• Tell your doctor what herbal products you use, especially St. John's Wort
• Tell your doctor if you have or have had heart problems, pancreatitis (swelling of the pancreas, a back gland that produces a substance to aid digestion), surgery to remove the entire stomach (total gastrectomy), or any condition that makes it difficult for you to digest lactose ( milk sugar) or other sugar
• Tell your doctor if you are pregnant or plan to become pregnant. You should not get pregnant while you are taking nilotinib. Talk with your doctor about contraceptive methods you can use during your treatment. If you become pregnant while using nilotinib, contact your doctor immediately. Nilotinib can harm the fetus
• Tell your doctor if you are breastfeeding. You should not breastfeed while you are taking nilotinib
• If you are having surgery, including dental surgery, tell your doctor or dentist about using nilotinib

Is the drug Nilotinib safe for pregnant and lactating women?

There are no adequate studies regarding the risks of using this drug in pregnant or breastfeeding women. Always consult your doctor to weigh the potential benefits and risks before using this medication. This drug is included in the risk of pregnancy category D according to the US Food and Drug Administration (FDA). (A = No risk, B = No risk in some studies, C = Possible risk, D = Positive evidence of risk, X = Contraindicated, N = Unknown)

There are not adequate studies in women to determine the risk to infants when using this medicine during breastfeeding. Consider the benefits and potential risks before using this medication while breastfeeding.

Nilotinib side effects

What are the possible side effects of Nilotinib?

Get emergency medical help if you have any of these signs of an allergic reaction: nausea, vomiting, sweating, hives, itching, difficulty breathing, swelling of your face, lips, tongue, or throat, or feel like you might pass out.

Stop using Nilotinib and call your doctor if you have any of the following serious side effects:

• Headache with chest pain and severe dizziness, fainting, fast or pounding heartbeat
• Fever, chills, body aches, flu symptoms, sores in mouth and throat
• Pale skin, weakness, easy bruising or bleeding
• Blood in the urine or stool
• Severe pain in the upper abdomen that spreads to the back
• Nausea, loss of appetite, dark urine, jaundice (yellowing of the skin or eyes)
• Lower back pain, numbness or tingling feeling around your mouth
• Urinating less than usual or not at all
• Muscle weakness, tightness, or contractions
• Fast or slow heart rate, weak pulse, feeling short of breath
• Sudden severe headache, confusion, problems with vision, feeling like they might pass out

Other common side effects may include:

• Diarrhea, constipation
• Mild skin rash, temporary hair loss
• Headaches, back pain, joint pain or muscle aches
• Tired feeling
• Cold symptoms such as stuffy nose, sneezing, coughing, sore throat

Not everyone experiences the following side effects. There may be some side effects not listed above. If you have concerns about certain side effects, consult your doctor or pharmacist.

Nilotinib Drug Warnings and Cautions

What medicines can interfere with the drug Nilotinib?

Drug interactions can change the performance of your medications or increase the risk of serious side effects. Not all possible drug interactions are listed in this document. Keep a list of all the products you use (including prescription / non-prescription drugs and herbal products) and consult your doctor or pharmacist. Do not start, stop, or change the dose of any medication without your doctor's approval

Some of the products that may interact with this medication include: antacids, H2 blockers (such as cimetidine / famotidine), proton pump inhibitors (such as omeprazole).

Other medicines that may affect the clearance of nilotinib from your body that may affect nilotinib's action. Examples include azole antifungals (such as itraconazole, ketoconazole), HIV protease inhibitors (such as ritonavir), macrolide antibiotics (such as clarithromycin), rifamycins (such as rifabutin), St John's Wort, drugs used to treat seizures (such as carbamazepine, phenytoin), among others. other.

Can certain foods and drinks interfere with the work of the Nilotinib drug?

Certain drugs should not be used with meals or when eating certain foods because drug interactions can occur. Consuming alcohol or tobacco with certain drugs can also cause interactions to occur. Discuss your use of drugs with food, alcohol, or tobacco with your health care provider.

• Food
• Grapefruit orange juice

What health conditions can interfere with the performance of the drug Nilotinib?

The presence of other health problems in your body can affect the use of this drug. Tell your doctor if you have other health problems, such as:

• Blood problems or bone marrow problems (for example, anemia, neutropenia, thrombocytopenia)
• Heart problems or blood vessel problems (for example, congestive heart failure, heart attack, ischemic heart disease, peripheral artery occlusion disease, slow heartbeat, stroke), or a history of
• Hyperkalemia (high potassium in the blood)
• Hypocalcemia (low calcium in the blood)
• Hyponatremia (low sodium in the blood)
• Hypophosphatemia (low phosphate in the blood)
• Pancreatitis (inflammation of the pancreas), history - Use with caution. It might make things worse.
• heart rhythm problems (for example, long QT syndrome)
• Hypokalemia (low potassium in the blood)
• Hypomagnesemia (low magnesium in the blood) - Should not be used in patients with this condition
• Lactose intolerance - Use with caution. This medicine contains lactose
• Disease caution - Use with caution. The effect can be increased due to slower clearance of the drug from the body
• Total gastrectomy (surgery that involves removing the entire stomach) - the effect of nilotinib may decrease in patients having this operation

Nilotinib Drug Interactions

The information provided is not a substitute for a doctor's prescription. ALWAYS consult your doctor or pharmacist before starting treatment.

What is the dosage for Nilotinib for adults?

Usual Adult Dose for Chronic Myeloid Leukemia

For use in patients newly diagnosed with chronic myeloid leukemia with positive Philadelphia chromosome (Ph + CML) in the chronic phase:

Initial dose: 300 mg orally twice a day, about 12 hours apart

For use in patients with chronic or accelerated phase Ph + CML who are resistant or intolerant of previous therapy using imatinib:

Initial dose: 400 mg orally twice a day, with a dose interval of about 12 hours.

What is the dosage of Nilotinib for children?

The dosage for children has not been determined. Consult your doctor for more information.

In what dosages and preparations is Nilotinib available?

Capsule, oral: 150 mg, 200 mg.

What to do in an emergency or overdose?

In case of an emergency or overdose, contact the local emergency services provider (119) or immediately to the nearest hospital emergency department.

Overdose symptoms may include:

• Fever, sore throat, chills, or other signs of infection
• Gag
• Drowsiness

What should I do if I forget to take medicine or forget to take medicine?

If you forget a dose of this medicine, take it as soon as possible. However, when it is nearing the time of the next dose, skip the missed dose and return to the usual dosing schedule. Don't double the dose.

Hello Health Group does not provide medical consultation, diagnosis or treatment.