Glyxambi: functions, dosage, side effects, how to use it

Uses

What medicine is Glyxambi?

Glyxambi is an oral drug that helps control blood sugar in adult patients with type two diabetes. Its use, balanced with a proper diet and exercise program, can help diabetes patients avoid kidney damage, blindness, nerve problems, amputations, and problems with sexual function. Glyxambi is not used for treatment in patients with type one diabetes.

Glyxambi is a drug consisting of a combination of empagliflozin and linagliptin. Both of these combinations can also reduce the risk of death from heart attack, stroke, or heart failure due to heart disease.

Empagliflozin in Glyxambi works by helping the kidneys remove glucose. In other words, the re-absorption by the kidneys leaves sugar to be excreted out of the body along with urine. Meanwhile, linagliptin works by increasing the production of incretin in the body which plays a role in insulin release, especially after eating. The combination of the two also lowers the amount of sugar your liver produces.

What are the rules for drinking Glyxambi?

Glyxambi is an oral medication that is taken by mouth, with or without food as directed by your doctor. Usually, Glyxambi is consumed once a day in the morning.

Your doctor may change your dose as needed for the treatment to work optimally for you. Follow your doctor's instructions when taking this drug. Do not change your dose or stop taking this drug without consulting your doctor. The dose given takes into account your health condition and your body's response to treatment.

To get maximum results, take this drug regularly every day. To make it easier for you to remember, take this drug at the same time every day. Tell your doctor if there is no improvement or if it gets worse. Your doctor may need to readjust the dose.

What are the storage rules for Glyxambi?

Store this medication at room temperature not exceeding 30 degrees Celsius. Avoid storing this drug from heat and direct light. Do not store this medication in a damp place, such as a bathroom. Keep out of reach of children and pets.

Do not flush or flush this medication down the toilet or drain unless instructed to do so. Discard this product if it has expired or is no longer needed. Ask your pharmacist or local waste disposal company about how to safely dispose of this product.

Dose

The information provided is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist before starting treatment.

What is the dosage of Glyxambi for adult patients?

Initial dose: empagliflozin 10 mg-linagliptin 5 mg, once daily in the morning

The dose may be increased to empagliflozin 25 mg-linagliptin 5 mg if the lower dose is tolerated.

Maximum daily dose: empagliflozin 25 mg-linagliptin 5 mg, once daily

What is the dosage of Glyxambi for pediatric patients?

The dosage in pediatric patients has not been established. Talk to your doctor about using the right medication for your child.

What is the dosage of Glyxambi for elderly patients?

Use the same dosage as an adult patient. Empagliflozin in Glyxambi is often indicated to be associated with the occurrence of osmotic diuresis, which is a condition in which an increase in the amount of urine due to high sugar levels is excreted in the urine. This condition will be more common in elderly patients aged 75 years or over who are taking empagliflozin.

In what dosage and preparation is Glyxambi (empagliflozin-linagliptin) available?

Tablet, Oral: 10 mg / 5 mg; 25 mg / 5 mg

Side effects

What side effects might be caused by consuming Glyxambi?

More frequent urination, dizziness, and lightheadedness may occur as a result of taking this drug. To avoid dizziness and vertigo, get up slowly if you are sitting and lying down. If this condition persists and even gets worse, contact your doctor immediately.

Stop treatment with Glyxambi if you experience the following complaints:

• Severe and lingering pain in the joints
• Pancreatitis which is characterized by pain in the gut that spreads to the back, nausea and vomiting, and a racing heart
• Symptoms of a bladder infection, namely pain or burning when urinating, cloudy urine, pain in the pelvis and waist
• Symptoms of genital infection (penis or vagina), characterized by pain, burning sensation, itching, rash, redness, bad odor, and unusual mucus discharge
• Symptoms of heart failure, such as shortness of breath even when lying down, swelling in the feet or ankles, weight gain
• Symptoms of a skin reaction, namely itching, sores, cracked skin
• Ketoacidosis (too many ketones in the blood), which is characterized by nausea, vomiting, stomach pain, confusion, drowsiness, or difficulty breathing

Some of the more common side effects include:

• Urination problems
• Sore throat
• Runny / stuffy nose, sinusitis

Consumption of Glyxambi can also cause you to lose a lot of fluids, aka dehydration. If this continues, it will have serious repercussions on the kidneys. Drink plenty of fluids to prevent dehydration. Tell your doctor if you are losing a lot of fluids such as nausea, vomiting, diarrhea, or excessive sweating.

Serious allergic reactions are known to rarely occur as a result of taking this drug. However, contact your doctor immediately if you notice any serious allergy symptoms, such as rash, itching, swelling of the face, tongue, and throat, severe dizziness, and difficulty breathing.

The list above is not a complete list regarding the side effects that may be caused by consuming Glyxambi. Talk to your doctor about the possible side effects that you are worried about will occur.

Warnings and precautions

What should I pay attention to before consuming Glyxambi?

• Tell your doctor if you have any drug allergies, especially to empagliflozin and linagliptin, as well as other drugs. Tell them about any allergies you have, such as food allergies, preservative allergies, or food coloring. Glyxambi may contain other ingredients that can also cause allergic reactions
• Tell your doctor about your medical history including past and current illnesses, especially if you have kidney problems, diabetes ketoacidosis, heart disease, liver disease, pancreatitis, low blood pressure, gallstones, high cholesterol or triglyceride levels in the blood, and genital infections
• This medicine may cause blurred vision, dizziness, or severe drowsiness as a result of a drastic drop or increase in blood sugar levels. Avoid activities that require high alertness, such as driving, before knowing how your body responds to this medication
• Limit alcohol use while you are taking this drug. Alcohol consumption can increase your risk of low blood sugar
• Tell your doctor if you plan to become pregnant or are pregnant but need to control blood sugar. Your doctor may prepare alternative treatments or make dosage adjustments

Is Glyxambi safe for pregnant and lactating women?

Based on studies conducted on animals (mice), the use of empagliflozin shows detrimental effects on the kidneys. Its use in pregnant women is not recommended, especially in the second and third trimesters of pregnancy. There is no adequate information regarding the excretion of Glyxambi through breast milk. Nursing mothers are advised not to take this drug while breastfeeding.

Drug Interactions

Certain drugs will cause interactions when used together. This causes one of the drugs to not work optimally or there is an increased risk of side effects. Even so, sometimes your doctor may prescribe the two drugs at the same time if needed by making a dose adjustment.

Tell your doctor about other medicines you are also taking before taking Glyxambi, especially if you are taking:

• Other oral diabetes medications
• Insulin
• Rifampin (for the treatment of tuberculosis)
• Medicines to treat blood pressure

The above list is not a complete list of drugs that interact with Glyxambi. Keep a list of all drugs that you have or are currently taking, and inform your doctor, both prescription / non-prescription drugs, vitamins, and herbal medicines before taking Glyxambi.

Overdose

What should I do in an emergency or overdose?

In case of an emergency or overdose, call emergency medical help immediately (119) or rush to the nearest hospital emergency department for help. Glyxambi overdose can cause severe hypoglycemia. Symptoms of hypoglycemia include extreme weakness, confusion, tremors, fainting, and seizures.

What if I forget my medication schedule?

Take the missed dose as soon as you remember. If the distance is close to the schedule for taking the next medication, ignore the missed dose. Continue the schedule for taking the medication according to the predetermined time. Do not double the dose to make up for a missed dose on one scheduled medication.