Dasatinib: functions, dosage, side effects, how to use it

What medicine is Dasatinib?

What is dasatinib for?

Dasatinib is a cancer drug. This drug is used to treat certain types of cancer such as chronic myeloid leukemia and acute lymphoblastic leukemia.

Dasatinib is a drug that works by slowing down or stopping the growth of cancer cells.

How to use dasatinib?

Take this medication with or without food as directed by your doctor, usually once daily. This medicine must be swallowed whole. Do not break, cut or crush the tablet. Avoid using antacids (eg, aluminum / magnesium hydroxide, calcium carbonate) within 2 hours before or after taking this medicine as they will decrease their effectiveness.

The dosage is based on your medical condition, laboratory tests, response to treatment, and other medications that can be used. Do not increase your dose or take this drug more often than prescribed. Your condition will not recover any sooner and the risk of serious side effects can be increased. Be sure to tell your doctor and pharmacist about all medicinal products you use (including prescription drugs, nonprescription drugs, and herbal products).

Avoid eating grapefruit or drinking grapefruit juice while using this medicine unless your doctor or pharmacist has said you can do it safely. This fruit can increase the chance of side effects of this drug. Ask your doctor or pharmacist for more details.

Because this medicine can be absorbed through the skin and lungs, women who are pregnant or who may become pregnant should not touch this medicine or inhale the powder from these tablets.

Follow the rules given by your doctor or pharmacist before starting treatment. If you have any questions, consult your doctor or pharmacist.

How to store dasatinib?

Dasatinib is a drug that should be stored at room temperature, away from direct light and damp places. Don't keep it in the bathroom. Don't freeze it. Other brands of this drug may have different storage rules. Observe the storage instructions on the product package or ask your pharmacist. Keep all medicines away from children and pets.

Do not flush medicines down the toilet or down the drain unless instructed to do so. Discard this product when it has expired or when it is no longer needed. Consult your pharmacist or local waste disposal company about how to safely dispose of your product.

Dasatinib dosage

The information provided is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist before starting treatment.

What is the dose of dasatinib for adults?

For treating leukemia, the dose of dacatanib is 100 mg orally once a day. The duration of treatment is given until the disease improves or the patient is no longer tolerant of the drug.

This medicine should be used at the lowest dose to achieve treatment success and minimize side effects.

What is the dose of dasatinib for children?

There is no prescribed dosage for this drug for children. This medicine can be dangerous for children. It is important to understand the safety of drugs before use. Consult your doctor or pharmacist for more information.

In what dosage is dasatinib available?

The dosage of dasatinib is:

Tablet, orally 20 mg
Tablet, orally 50 mg
Tablet, orally 70 mg
Tablet, orally 80 mg
Tablet, orally 100 mg
Tablet, orally 140 mg

Dasatinib side effects

What side effects can be experienced due to dasatinib?

The most common side effects of the drug dasatinib are:

Headache
Tired feeling
Nausea and vomiting
Mild skin rash

Not everyone experiences this side effect. There may be some side effects not listed above. If you have concerns about certain side effects, consult your doctor or pharmacist.

Dasatinib Drug Warnings and Cautions

What should be known before using dasatinib?

Some things you should know before taking dasatinib are:

Before using dasatinib, tell your doctor and pharmacist if you are allergic to dasatinib, any other drugs, or any of the ingredients in dasatinib tablets. Ask your pharmacist for a list of the ingredients that make up the drug.
Tell your doctor and pharmacist about prescription and nonprescription drugs, vitamins, nutritional supplements, and herbal products that you are using or will be using. Your doctor may need to change the dose of your medication or monitor you carefully for side effects.
If you are taking an antacid, such as aluminum hydroxide / magnesium hydroxide (Maalox), calcium carbonate (Tums) or calcium carbonate and magnesium (Rolaids), take it 2 hours before or 2 hours after you use dasatinib.
Tell your doctor about any herbal products you use, especially St. John's Wort.
Tell your doctor if you have or have ever had lactose intolerance (when the body is unable to digest dairy products), low blood levels of potassium or magnesium, long QT syndrome (a heart condition that can cause dizziness, fainting, or an irregular heartbeat. ), problems with the immune system, or liver, lungs or heart disease.
Tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. You should not get pregnant while you are using dasatinib. If you become pregnant while using dasatinib, contact your doctor. Women who are pregnant should not touch crushed or damaged dasatinib tablets. Dasatinib can be harmful to the fetus.
If you are having surgery, including dental surgery, tell your doctor or dentist about using this medication.

Is dasatinib safe for pregnant and lactating women?

There are no adequate studies regarding the risks of using this drug in pregnant or nursing women. Always consult your doctor to weigh the potential benefits and risks before using this medication. This drug is included in the risk of pregnancy category D according to the US Food and Drug Administration (FDA) United States, or the equivalent of the POM in Indonesia.

The following references the pregnancy risk categories according to the FDA:

A = Not at risk
B = No risk in several studies
C = May be risky
D = There is positive evidence of risk
X = Contraindicated
N = Unknown

There are not adequate studies in women who pose a risk to the baby when using this medicine during breastfeeding. Weigh the benefits against the risks before using this medicine while breastfeeding.

Drug Interactions Dasatinib

What medicines may interact with dasatinib?

Although certain drugs should not be used together, in other cases two different drugs can be used together even if interactions are possible. In this case, your doctor may want to change the dose or take other precautions that may be needed.

When you are using this medicine it is important that your doctor knows if you are currently taking any of the medicines that are listed below. The following interactions are selected on the basis of their potential significance and are not necessarily all inclusive.

Using this medication with any of the following medicines is not recommended. Your doctor may decide not to treat you with this drug or change some of the other medicines you use.

Amifampridine
Cisapride
Dronedarone
Fluconazole
Mesoridazine
Nelfinavir
Pimozide
Piperaquine
Posaconazole
Saquinavir
Sparfloxacin
Thioridazine

Using this medication with any of the following medicines is not usually recommended, but may be necessary in some cases. If the two drugs are prescribed at the same time, your doctor may change the dose or adjust how often you use one or both drugs.

Alfuzosin
Amiodarone
Amitriptyline
Amoxapine
Anagrelide
Apomorphine
Aprepitant
Aripiprazole
Arsenic Trioxide
Asenapine
Astemizole
Atazanavir
Azithromycin
Buserelin
Carbamazepine
Ceritinib
Chloroquine
Chlorpromazine
Cimetidine
Ciprofloxacin
Citalopram
Clarithromycin
Clomipramine
Clozapine
Cobicistat
Crizotinib
Dabrafenib
Delamanid
Desipramine
Deslorelin
Dexamethasone
Disopyramide
Dofetilide
Dolasetron
Domperidone
Droperidol
Erythromycin
Escitalopram
Eslicarbazepine Acetate
Esomeprazole
Famotidine
Fingolimod
Flecainide
Fluoxetine
Fosaprepitant
Fosphenytoin
Gatifloxacin
Gemifloxacin
Gonadorelin
Goserelin
Granisetron
Halofantrine
Haloperidol
Histrelin
Ibutilide
Idelalisib
Iloperidone
Imipramine
Indinavir
Itraconazole
Ivabradine
Ketoconazole
Lansoprazole
Lapatinib
Leuprolide
Levofloxacin
Lopinavir
Lumefantrine
Mefloquine
Methadone
Metronidazole
Mifepristone
Mitotane
Moxifloxacin
Nafarelin
Nefazodone
Nilotinib
Nizatidine
Norfloxacin
Nortriptyline
Octreotide
Ofloxacin
Omeprazole
Ondansetron
Paliperidone
Pantoprazole
Pazopanib
Perflutren Lipid Microsphere
Phenobarbital
Phenytoin
Primidone
Procainamide
Prochlorperazine
Promethazine
Propafenone
Protriptyline
Quetiapine
Quinidine
Quinine
Rabeprazole
Ranitidine
Ranolazine
Rifabutin
Rifampin
Ritonavir
Salmeterol
Sevoflurane
Siltuximab
Sodium Phosphate
Sodium Phosphate, Dibasic
Sodium Phosphate, Monobasic
Solifenacin
Sorafenib
Sotalol
St. John's Wort
Sunitinib
Telithromycin
Terfenadine
Tetrabenazine
Topotecan
Toremifene
Trazodone
Trifluoperazine
Trimipramine
Triptorelin
Vandetanib
Vardenafil
Vemurafenib
Vinflunine
Voriconazole
Ziprasidone

Using this medication with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If the two drugs are prescribed together, your doctor may change the dose or adjust how often you use one or both drugs.

Aluminum Carbonate, Basic
Aluminum Hydroxide
Aluminum Phosphate
Calcium
Calcium Carbonate
Dihydroxyaluminum Aminoacetate
Dihydroxyaluminum Sodium Carbonate
Magaldrate
Magnesium Carbonate
Magnesium Hydroxide
Magnesium Oxide
Magnesium Trisilicate
Simvastatin
Sodium Bicarbonate

Can food or alcohol interact with dasatinib?

Certain drugs should not be used with meals or when eating certain foods because drug interactions can occur. Consuming alcohol or tobacco with certain drugs can also cause interactions to occur. Discuss your use of drugs with food, alcohol, or tobacco with your health care provider.

Certain medications should not be used at or around the time of eating food or when eating certain types of food because interactions can occur. Using alcohol or tobacco with certain drugs can also cause interactions. The following interactions are selected on the basis of their potential significance and are not necessarily all inclusive.

Using this medication with any of the following foods is usually not recommended, but may not be avoided in some cases. If taken at the same time, your doctor may change your dose or adjust how often you use this drug, or give specific instructions about use of food, alcohol, or tobacco.

Grapefruit juice

What health conditions can interact with dasatinib?

The presence of other health problems in your body may affect the use of this drug. Some of the health conditions that may interact with the drug dasatinib are:

Bleeding problems (for example, stomach bleeding)
Blood or bone marrow disorders (eg, anemia, neutropenia, thrombocytopenia)
Congestive heart failure
Edema
History of heart attack
Heart disease (for example, cardiomyopathy)
Heart rhythm problems (eg, long-term congenital QT syndrome, advanced QTc)
Hypokalemia (low potassium in the blood)
Hypomagnesemia (low magnesium in the blood)
Infection
Lactose intolerance

Dasatinib overdose

What should I do in an emergency or overdose?

In case of an emergency or overdose, contact the local emergency services provider (112) or immediately to the nearest hospital emergency department.

What should I do if I miss a dose?

If you forget a dose of this medicine, take it as soon as possible. However, when it is nearing the time of the next dose, skip the missed dose and return to the usual dosing schedule. Don't double the dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.