Chenodiol (chenodeoxycholic acid): functions, dosage, side effects, how to use

Chenodiol (Chenodeoxycholic Acid) What Medicine?

What is chenodiol for?

Chenodeoxycholic acid or chenodiol is a drug used to dissolve certain types of gallstones (non-calcified). Chenodiol is an acid for dissolving stones in bile. Chenodiol is a drug that may have been used in gallstone surgery, but there is a risk of complications. If the gallstones do not dissolve, surgery may still be needed.

How to use chenodiol?

This medication is taken with or without food, usually twice a day. Once in the morning and once in the evening, or according to your doctor's instructions. The dosage is based on medical condition, weight, and response to treatment.

Antacids containing aluminum and drugs that can lower cholesterol (bile acid-binding resins such as cholestyramine or colestipol) can decrease the absorption of the drug in the body. If you are taking this medication, separate the medication from chenodiol for at least 4 hours.

To reduce the risk of side effects such as diarrhea, your doctor will give you a light dose initially and slowly increase your dose. Follow the doctor's instructions carefully. Tell your doctor if you have acute diarrhea. Your doctor may decrease the dose or stop using the drug.

Do not increase your dose or use this medication more frequently without your doctor's approval. Your condition will not improve any sooner, and the risk of serious side effects can increase.

Use this remedy regularly for maximum results. To remind yourself, use it at the same time every day. Do not stop using your medication without talking to your doctor.

It may take 24 months for the gallstones to dissolve completely. Your doctor will perform tests (gallstone sonogram or x-ray) to check the progress.

Attend all your medical appointments. Tell your doctor if your condition persists or gets worse (stomach pain, nausea, or vomiting).

How is chenodiol stored?

This medication is best stored at room temperature, away from direct light and damp places. Don't keep it in the bathroom. Don't freeze it. Other brands of this drug may have different storage rules. Observe the storage instructions on the product package or ask your pharmacist. Keep all medicines away from children and pets.

Do not flush medicines down the toilet or down the drain unless instructed to do so. Discard this product when it has expired or when it is no longer needed. Consult your pharmacist or local waste disposal company about how to safely dispose of your product.

Rules of Use Chenodiol (Chenodeoxycholic Acid)

The information provided is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist before starting treatment.

What is the chenodiol dosage for adults?

For patients with gallstones that are transparent on x-ray of the gallbladder the risk may increase due to systemic disease or age. As for general use, use 13 to 16 mg / kg / day divided into 2 doses, morning and evening.

Starting with 250 mg twice daily for the first two weeks and increasing to 250 mg / day every week until you reach the recommended or maximum dose.

If diarrhea occurs at the time of increasing the dose or after treatment, it will usually be controlled with a temporary dose adjustment until the last dose is tolerated. Doses usually less than 10 mg / kg are usually ineffective and can increase the risk of cholecystectomy and are not recommended. Drug safety after 24 months of use has not been determined.

What is the dosage of chenodeoxycholic acid for children?

The safety and effectiveness of the drug has not been determined for children (under 18 years).

In what dosage is chenodeoxycholic acid available?

Tablet

Chenodiol dosage (Chenodeoxycholic Acid)

What side effects can be experienced due to chenodiol?

Chenodiol is a drug that will cause side effects. You should contact your doctor if there are any side effects that may be associated with taking chenodeoxycholic acid, such as:

• black stool
• chest pain
• exuberant
• cough
• fever
• pain or difficulty urinating
• short breath
• sore throat
• sore, white patches on the lips or in the mouth
• swollen glands
• unusual bleeding or bruising
• feeling tired or weak is not uncommon

Some of the side effects associated with chenodeoxycholic acid may not require medical attention. When your body can adjust the medication during treatment, the side effects will gradually disappear. Your healthcare professional can tell you how to reduce these side effects. If these side effects persist, are bothersome, or if you have any questions about these side effects, you can check with your healthcare professional:

Common side effects:

• Diarrhea

Uncommon side effects:

• abdominal pain
• acid in the stomach
• burp
• swollen
• cramps
• have difficulty with bowel movements (bowel movements)
• there is angina in the stomach
• feel full
• burning feeling
• difficulty defecating
• lost appetite
• nausea and vomiting
• chest pain below the sternum
• pain or discomfort in the chest, above the stomach or throat
• fart
• stomach feels bad
• weight loss.

Not everyone experiences this side effect. There may be some side effects not listed above. If you have concerns about certain side effects, consult your doctor or pharmacist.

Chenodiol (Chenodeoxycholic Acid) side effects

What should be known before using chenodiol?

Chenodiol is a drug that can cause a reaction. Several medical conditions can interact with chenodiol. Tell your doctor or pharmacist if you have any medical conditions, especially if you:

• are pregnant, planning pregnancy, breastfeeding, or may be pregnant
• if you are taking prescription or nonprescription drugs, herbal medicines, or if you are taking dietary supplements
• if you are allergic to certain medications, foods, or substances
• if you have had liver problems, inflammation of the pancreas (pancreatitis), bile ducts (such as fistulas), or colon cancer.

Some DRUGS MAY INTERACT with chenodiol. Tell your health care professional if you are currently using drugs, especially the following drugs:

• • Anticoagulants (such as warfarin) because they can increase the risk of bleeding
  • Estrogens, fibrates (such as clofibrate), or oral contraceptives, because they reduce the effectiveness of chenodiol.

Perhaps the above list is not a complete list of drug interactions. Ask your healthcare professional if chenodiol can interact with any medications you are currently taking. Check with a health care professional before you use, stop, or change the dose of any medicine.

Is chenodeoxycholic acid safe for pregnant and lactating women?

There are no adequate studies regarding the risks of using this drug in pregnant or breastfeeding women. Always consult your doctor to weigh the potential benefits and risks before using this medication. This drug is included in the risk of pregnancy category X according to the US Food and Drug Administration (FDA). The following references the pregnancy risk categories according to the FDA:

• A = No risk,
• B = not at risk in several studies,
• C = May be risky,
• D = There is positive evidence of risk,
• X = Contraindicated,
• N = Unknown

Chenodiol (Chenodeoxycholic Acid) Drug Warnings and Cautions

What medicines may interact with chenodiol?

Although some drugs should not be taken at the same time, in other cases some drugs can also be used together even though interactions may occur. In such cases, the doctor may change the dose, or take other preventive measures as needed. Tell your doctor if you are taking any other over-the-counter or prescription drugs.

Can food or alcohol interact with chenodiol?

Certain drugs should not be used with meals or when eating certain foods because drug interactions can occur. Consuming alcohol or tobacco with certain drugs can also cause interactions to occur. Discuss your use of drugs with food, alcohol, or tobacco with your health care provider.

What health conditions can interact with chenodiol?

Chenodiol is a drug that can interact with certain conditions. Any other health conditions you have can affect the use of this drug. Always tell your doctor if you have other health problems, especially:

• bile duct problems (such as narrowing, fistula, swelling, intrahepatic cholestatis, primary biliary cirrhosis) or
• gallbladder problems (such as the gallbladder can't be seen using special dyes, or gallbladder complications) or
• liver problems (such as deterioration of the liver, sclerosing cholangitis) - should not be used in patients with these conditions.
• colon cancer or
• liver pain (including hepatitis) or
• high levels of enzymes in the liver — use with caution as they can worsen this condition.

Chenodiol Drug Interactions (Chenodeoxycholic Acid)

What should I do in an emergency or overdose?

In case of an emergency or overdose, contact the local emergency services provider (112) or immediately to the nearest hospital emergency department.

What should I do if I miss a dose?

If you forget a dose of this medicine, take it as soon as possible. However, when it is nearing the time of the next dose, skip the missed dose and return to the usual dosing schedule. Don't double the dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.