Aldesleukin: functions, dosage, side effects, how to use

Functions & Usage

What is Aldesleukin used for?

Aldesleukin is a drug used to treat advanced forms of kidney or skin cancer (cancer that has spread to other parts of the body). This medicine is the same substance that your body normally makes (interleukin-2). In the body, this drug is thought to work by affecting the body's natural defenses (immune system). This effect slows or stops the growth of cancer cells.

OTHER USES: This section lists uses for this drug that are not listed on approved labels, but may be prescribed by your healthcare professional. Use this medication for the conditions listed below only if it has been prescribed by your doctor and health care professional.

This drug can also be used to treat Kaposi's Sarcoma.

What are the rules for using the drug Aldesleukin?

This medication is given by injection into a vein for more than 15 minutes by a health care professional. This medication may also be given by other means as directed by your doctor.

This medicine is usually given every 8 hours for 5 consecutive days. However, your doctor may decide to delay or stop your treatment depending on how your body responds to this drug. After this treatment period, you will be given time to rest and recover before getting this medication again. A therapy can include up to 28 doses of this drug. To ensure that you receive each dose scheduled as directed, it is important to keep all your medical data while receiving this medication.

Depending on your response, your doctor may decide that a second therapy will be of great help.

Dosage is based on your medical condition, body weight, response to treatment, and your side effects.

How to store Aldesleukin?

Store at room temperature, away from direct light and damp places. Don't keep it in the bathroom. Don't freeze it. Other brands of this drug may have different storage rules. Observe the storage instructions on the product package or ask your pharmacist. Keep all medicines away from children and pets.

Do not flush medicines down the toilet or down the drain unless instructed to do so. Discard this product when it has expired or when it is no longer needed. Consult your pharmacist or local waste disposal company about how to safely dispose of your product.

Precautions & Warnings

What should be considered before using Aldesleukin drugs?

Before receiving Aldesleukin:

• Tell your doctor and pharmacist that you are allergic to Aldesleukin, other drugs or other ingredients contained in Aldesleukin injection. Ask your pharmacist for a list of raw materials for the drug.
• Tell your doctor and pharmacist about prescription or non-prescription medications, vitamins, nutritional supplements, and herbal products that you are currently taking or are planning to take. Make sure you mention the following types of drugs: beta blockers such as atenolol (Tenormin), labetalol (Normodyne), metoprolol (Lopressor, Toprol XL), nadolol (Corgard), and propranolol (Inderal); certain cancer chemotherapy drugs such as asparaginase (Elspar), cisplatin (Platinol), dacarbazine (DTIC-dome), doxorubicin (Doxil), interferon-alfa (Pegasys, PEG-Intron), methotrexate (Rheumatrex, Trexall), and tamoxifen ( Nolvadex); medicines for high blood pressure; medicines for nausea and vomiting; narcotics and other painkillers; sedatives, sleeping pills, and sedatives; steroids such as dexamethasone (Decadron, Dexone), methylprednisolone (Medrol), and prednisone (Deltasone); and steroid creams, lotions, or ointments such as hydrocortisone (Cortizone, Westcort). Also tell your doctor and pharmacist about all the drugs you take so they can check whether the drugs you are currently taking can increase the risk of potential kidney or liver damage during your treatment with Aldesleukin.
• Tell your doctor if you have had seizure, gastrointestinal (GI) bleeding requiring surgical treatment, or other serious GI, heart, nervous system, or kidney problems after you receive Aldesleukin or if you have had an organ transplant (surgery to replace an organ in the body ). Your doctor may not want you to receive Aldesleukin.
• Tell your doctor if you have or have had seizures, Crohn's disease, scleroderma (a disease that affects the tissues that support the skin and internal organs), thyroid disease, arthritis, diabetes, myasthenia gravis (a disease that weakens the muscles), or cholecystitis ( inflammation of the gallbladder causing severe pain).
• Tell your doctor if you are pregnant, or are planning to become pregnant or are breastfeeding. If you become pregnant while receiving Aldesleukin then contact your doctor. You should not be breastfeeding at the time of receiving this medicine.

Is Aldesleukin safe for pregnant and lactating women?

There are no adequate studies regarding the risks of using this drug in pregnant or breastfeeding women. Always consult your doctor to weigh the potential benefits and risks before using this medication. This medicine is included in the pregnancy risk category C. (A = No risk, B = No risk in some studies, C = Possible risk, D = There is positive evidence of risk, X = Contraindicated, N = unknown)

It is not known whether Aldesleukin passes into breast milk or the drug could harm a baby who is being breastfed by a mother receiving Aldesleukin treatment. Tell your doctor if you are breastfeeding a baby.

Side effects

What are the possible side effects of Aldesleukin?

Seek immediate medical help if you experience any of the following signs of an allergic reaction: hives, difficulty breathing, swelling of the face, lips, tongue, or throat.

Contact your doctor if you experience serious side effects such as the following:

• Sleepy
• Feelings like you might pass out
• Chest pain, fast or pounding heartbeat
• Runny or stuffy nose, coughing, fast breathing and heart rate, difficulty breathing, swelling and pain in any part of your body
• Problems with vision, speech and body coordination
• Changes in mood or behavior, confusion, agitation and hallucinations
• Seizures
• Swelling, rapid weight gain
• Black or bloody stools
• Urinating less than usual or not at all
• Rash and blisters
• Jaundice (yellowing of the eyes or skin)
• Signs of infection such as fever, chills, sore throat, flu symptoms, easy bruising or bleeding (nosebleeds, bleeding gums), nausea and vomiting, mouth sores, unusual weakness.

Less serious side effects include:

• Mild stomach pain
• Tired feeling
• Drowsiness, dizziness, restlessness
• Diarrhea, loss of appetite

Not everyone experiences the following side effects. There may be some side effects not listed above. If you have concerns about certain side effects, consult your doctor or pharmacist.

Drug Interactions

What drugs can interfere with the drug Aldesleukin?

Drug interactions can change the performance of your medications or increase the risk of serious side effects. Not all possible drug interactions are listed in this document. Keep a list of all the products you use (including prescription / non-prescription drugs and herbal products) and consult your doctor or pharmacist. Do not start, stop, or change the dose of any medication without your doctor's approval.

Taking Aldesleukin with other drugs that make you drowsy or slow your breathing can increase this effect. Ask your doctor before taking Aldesleukin with sleeping pills, narcotic pain medication, muscle relaxants, or medication for anxiety, depression, or seizures.

Aldesleukin can harm your kidneys. This effect increases if you are also taking certain other medications, including: antivirals, chemotherapy, injectable antibiotics, drugs for intestinal disorders, drugs to prevent organ transplant rejection, and some painkillers or arthritis medications (including aspirin, Tylenol, Advil). , and Aleve).

Can certain foods and drinks interfere with the work of Aldesleukin drugs?

Certain drugs should not be used with meals or when eating certain foods because drug interactions can occur. Consuming alcohol or tobacco with certain drugs can also cause interactions to occur. Discuss your use of drugs with food, alcohol, or tobacco with your health care provider.

What health conditions can interfere with the performance of the drug Aldesleukin?

Any other health conditions you have can affect the use of this drug. Always tell your doctor if you have other health problems, especially:

• Abnormal lung function tests
• Abnormal thalium stress test
• Arrhythmia (heart rhythm problems) is uncontrollable or unresponsive
• Chest pain (with ECG changes), consistent with angina or heart attack
• Heart disease (for example, cardiac tamponade)
• Intubation for more than 72 hours
• Kidney failure (requires dialysis for more than 72 hours)
• Mental illness (for example, coma or psychosis for more than 48 hours)
• Allograft organ
• Seizures, recurring or uncontrollable
• Problems with the stomach or intestines (for example, bleeding requiring surgery, blockage, perforation)
• Ventricular tachycardia (abnormal heart rhythm problems), ongoing - Should not be given to patients with this condition.
• Allergic reactions (for example, Stevens-Johnson syndrome)
• Autoimmune diseases (eg, bullous pemphigoid, inflammatory arthritis, scleroderma
• Cerebral Vasculitis
• Cholecystitis (inflammation or inflammation of the gallbladder)
• Crohn's disease
• Diabetes
• Eye problems (for example, oculo-bulbar myasthenia gravis)
• Hypercalcemia (high calcium in the blood)
• Hypotension (low blood pressure)
• Kidney disease (for example, crescentic IgA glomerulonephritis)
• Liver disease
• Lung disease
• Seizures, have a history of having had seizures
• Thyroid disease - Use with caution. It might make things worse.
• Infection - May decrease your body's ability to fight infection.

Dose

The information provided is not a substitute for a doctor's prescription. ALWAYS consult your doctor or pharmacist before starting treatment.

What is the dose of the drug Aldesleukin for adults?

Usual Adult Dose for Renal Cell Carcinoma

0.037 mg / kg by IV infusion every 8 hours

Infusions can be given every 8 hours for a maximum of 14 doses. A further 9 days of rest, the schedule can be repeated for 14 doses, up to a maximum of 28 doses per therapy, with adjustments.

Usual adult dose for Malignant Melanoma

0.037 mg / kg by IV infusion every 8 hours

Infusions can be given every 8 hours for a maximum of 14 doses. A further 9 days of rest, the schedule can be repeated for 14 doses, up to a maximum of 28 doses per course, with adjustment.

What is the dosage of the drug Aldesleukin for children?

The dosage for children has not been determined. Consult your doctor for further information.

In what dosages and preparations is Aldesleukin available?

Lyophilized preservative-free powder for recovery 22 million units (1.3 mg) bottles (18 million units per mL when diluted)

What to do in an emergency or overdose?

In case of an emergency or overdose, contact the local emergency services provider (119) or immediately to the nearest hospital emergency department.

Symptoms of an overdose include:

• Seizures
• Fast or irregular heartbeat
• Coma
• The frequency of water money decreases
• Swelling of the face, arms, hands, feet, ankles, or lower legs
• Unusual fatigue or weakness
• Stomach ache
• Vomit that is bloody or looks like coffee grounds
• Blood in stool
• Black stool

What should I do if I forget to take medicine or forget to take medicine?

If you forget a dose of this medicine, take it as soon as possible. However, when it is nearing the time of the next dose, skip the missed dose and return to the usual dosing schedule. Don't double the dose.

Hello Health Group does not provide medical consultation, diagnosis or treatment.