Bupropion: function, dosage, side effects, how to use

What Drug Bupropion?

What is Bupropion for?

Bupropion is a drug used to treat depressive disorders. In addition, bupropion is a drug that is also used to treat attention deficit hyperactivity (ADHD) and helps overcome smoking addiction and bipolar disorder.

OTHER PURPOSES: This section lists uses of Bupropion that are not listed on approved labels, but may be prescribed by your healthcare professional. Use this medication for the conditions listed below only if it has been prescribed by your doctor and healthcare professional.

How do you use Bupropion?

Take this drug in accordance with the doctor's instructions and the instructions listed on the package. If you have questions, ask your doctor or pharmacist.

Do not increase or decrease the dose that has been prescribed without the doctor's knowledge, as there is a very large risk of side effects. Do not take more than 150 mg of the drug at a time and never take more than 450 g per day.

This medicine may cause sleep disturbances and reduce the risk of seizures. To prevent these sleep problems from occurring, do not take the drug close to your bedtime. Also, avoid driving or operating machinery that requires full concentration after you take the drug bupropion.

Take this medicine regularly to get optimal benefits. To help you remember, take this medication at the same time each day. Do not change or stop using this medication suddenly before consulting your doctor.

It can take about 4 weeks or more to get optimal benefits from this drug. Continue to take this medication as directed by your doctor. Immediately consult a doctor if your condition worsens.

How to store Bupropion?

This medication is best stored at room temperature, away from direct light and damp places. Don't keep it in the bathroom. Don't freeze it. Other brands of this drug may have different storage rules. Observe the storage instructions on the product package or ask your pharmacist. Keep all medicines away from children and pets.

Do not flush medicines down the toilet or down the drain unless instructed to do so. Discard this product when it has expired or when it is no longer needed. Consult your pharmacist or local waste disposal company about how to safely dispose of your product.

Bupropion dosage

The information provided is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist before starting treatment.

What is the dosage of Bupropion for adults?

The dosage for using the bupropion drug is:

To treat depression

Bupropion hydrochloride: Immediate-release tablets (Wellbutrin (R))

Initial dose: 100 mg orally twice a day, the dose of the drug will increase after 3 days of use, 100 mg 3 times a day
Follow-up dose: 100 mg orally three times a day
Maximum dose: 450 mg orally per day, up to 4 times usage; single use dose should not be more than 150 mg

Sustained-release tablets (Wellbutrin SR (R))

Initial dose: 150 mg orally once a day, taken in the morning, the dose of the drug will increase after 3 days of use, 150 mg twice a day
Follow-up dose: 150 mg orally twice a day
Maximum dose: 200 mg orally twice a day, single use dose should not be more than 200 mg

Extended-release tablets (Wellbutrin XL (R))

Initial dose: 150 mg orally once a day, taken in the morning, the dose of the drug will increase after 4 days of use, 300 mg once a day
Follow-up dose: 300 mg orally once a day
Maximum dose: 450 mg orally once a day

Bupropion hydrobromide: Extended-release tablets (Aplenzin (R))

Initial dose: 150 mg orally once a day, taken in the morning, the dose of the drug will increase after 4 days of use, 348 mg once a day
Follow-up dose: 348 mg orally once a day
Maximum dose: 522 mg orally once a day

Information:

Rapidly dissolving drugs should be taken at least every 6 hours
Slowly dissolving drugs should be taken at least every 8 hours
Long-dissolving drugs should be taken at least every 24 hours
The follow-up dose for the rapidly dissolving drug should not be more than 100 mg per day within the first 3 days of use
In order not to exceed the maximum dose (150 mg for fast-dissolving drugs), you should take 100 mg tablets that are taken 4 times a day as recommended.
Oral drug Bupropion hydrobromide (Aplenzin (R)) 174 mg equivalent to bupropion hydrochloride 150 mg
Patients should receive periodic checks to determine the correct dosage and medication

To stop smoking

Bupropion hydrochloride (Zyban (R))

Initial dose: 150 mg orally three times a day, the dose of the drug can be changed to 150 mg orally twice a day
Follow-up dose: 150 mg orally twice a day
Maximum dose: The daily dose of the drug should not be more than 300 mg, for single use should not be more than 150 mg
Duration: 7 to 12 weeks

Information:

Start taking this drug the first week without stopping; the time to stop using the drug should be determined within the first two weeks of treatment
The minimum time span for using the drug is 8 hours
Can use the transdermal nicotine system
If there is no improvement within 12 weeks of use, treatment should be stopped. Subsequent treatment must be closely monitored

What is the dosage of Bupropion for children?

There is no provision for the dose of this drug for children. This medicine can be dangerous for children. It is important to understand the safety of drugs before use. Consult your doctor or pharmacist for more information.

In what dosage is Bupropion available?

The dosage and preparation of bupropion are:

Tablet, Oral, hydrochloride:

Wellbutrin: 75 mg, 100 mg
Generic: 75 mg, 100 mg

12 hour Extended Release Tablet, Oral:

Generic: 150 mg

12 hour Extended Release Tablets, Oral, hydrochloride:

Budeprion SR: 100 mg
Budeprion SR: 150 mg
Buproban: 150 mg
Wellbutrin SR: 100 mg, 150 mg, 200 mg
Zyban: 150 mg
Generic: 100 mg, 150 mg, 200 mg

24 hour Extended Release Tablets, Oral, hydrobromide:

Aplenzin: 174 mg, 348 mg, 522 mg

12 Hour Extended Release Tablets, Oral, as hydrochloride:

Forfivo XL: 450 mg
Wellbutrin XL: 150 mg, 300 mg
Generic: 150 mg, 300 mg

Bupropion side effects

What side effects can be experienced due to Bupropion?

Drug reactions will be different from person to person. However, some of the side effects that can arise after taking bupropion are:

Dry mouth, nausea and upset stomach
Headache, dizziness and ringing in the ears
Not interested in sexual intercourse
Sore throat, muscle aches
Itchy skin, easy sweating and frequent urination
Change in appetite, weight gain or loss

Not everyone experiences the above side effects. There may be some side effects not listed above. If you have concerns about certain side effects, consult your doctor or pharmacist.

Report any symptoms that appear to the doctor, such as mood changes and behavior, anxiety and panic easily, sleeping problems, or if you feel stressed, irritable, aggressive, hyperactive (mentally and physically), or have suicidal thoughts or self-harm .

Some of the conditions that make you need to contact your doctor immediately after taking bupropion are:

Unstable heartbeat.
Fever, swollen glands, hives, and joint pain.
Confusion, seizures, problems with concentration, hallucinations, and abnormal thoughts and behavior.
A severe skin reaction, such as a red or purple sore that then spreads until it peels off
Sore throat, swelling of the face or tongue, and hot eyes.

Bupropion Drug Warnings and Cautions

What should be known before using Bupropion?

Before using certain drugs, consider the risks and benefits first. This is a decision you and your doctor will have to make. Some things that must be considered before taking bupropion are:

Do not take other medicines that contain bupropion at one time.
Tell your doctor or pharmacist any medications, vitamins, supplements, and herbal products you are taking, such as atenolol (Tenormin), labetalol (Normodyne), metoprolol (Lopressor, Toprol XL), nadolol (Corgard), and propranolol (Inderal); cimetidine (Tagamet); clopidogrel (Plavix); cyclophosphamide (Cytoxan, Neosar); efavirenz (Sustiva, in Atripla); insulin or oral medications for diabetes; treatment for heart rate flecainide (Tambocor) and propafenone (Rythmol); treatment for mental illness such as haloperidol (Haldol), risperidone (Risperdal), and thioridazine (Mellaril); drugs for seizures such as carbamazepine (Tegretol), phenobarbital (Luminal, Solfoton), and phenytoin (Dilantin); levodopa (Sinemet, Larodopa); lopinavir and ritonavir (Kaletra); nelfinavir (Viracept); nicotine patch; oral steroids such as dexamethasone (Decadron, Dexone), methylprednisolone (Medrol), and prednisone (Deltasone); orphenadrine (Norflex); Antidepressant drugs such as citalopram (Celexa), desipramine (Norpramin), fluoxetine (Prozac, Sarafem, in Symbyax), fluvoxamine (Luvox), imipramine (Tofranil), nortriptyline (Aventyl, Pamelor), paroxetine (Paxil) and sertraline (Paxil); ritonavir (Norvir); sleeping pills; tamoxifen (Nolvadex, Soltamox); theophylline (Theobid, Theo-Dur, others); thiotepa; and ticlopidine (Ticlid). Your doctor may change the dose of medication to prevent side effects
Tell your doctor if you have had seizures, anorexia nervosa or bulimia (eating disorder). Also tell your doctor if you regularly consume large amounts of alcohol and want to quit but can't. Doctors will usually recommend that you do not take this drug
Tell your doctor if you have used illegal drugs, used over-the-counter drugs and if you have had a heart attack, have had head injuries, brain tumors, high blood pressure; diabetes; or liver, kidney or heart disease. In addition, you should also tell your doctor if you are doing nicotine-withdrawal therapy
Tell your doctor if you are or plan to become pregnant or are breastfeeding. If you become pregnant while taking this drug, call your doctor right away
You should know that this medicine can cause closed glaucoma (a condition in which fluid cannot enter and flow in the eye and causes eye problems and pressure and blurred vision). Also, if you feel nauseous, have changes in your eyes such as a change in color or shape, contact your doctor immediately before taking this drug.

Is Bupropion safe for pregnant and lactating women?

There are no adequate studies regarding the risks of using this drug in pregnant or breastfeeding women. Always consult your doctor to weigh the potential benefits and risks before using this medication. This drug is included in the risk of pregnancy category C according to the US Food and Drug Administration (FDA).

The following references the pregnancy risk categories according to the FDA:

A = No risk,
B = not at risk in several studies,
C = May be risky,
D = There is positive evidence of risk,
X = Contraindicated,
N = Unknown

Bupropion Drug Interactions

What medicines may interact with Bupropion?

Drug interactions can change the performance of your medications or increase the risk of serious side effects. Not all possible drug interactions are listed in this document. Keep a list of all the products you use (including prescription / non-prescription drugs and herbal products) and consult your doctor or pharmacist. Do not start, stop, or change the dose of any medication without your doctor's approval.

Taking this medication with the drugs below may increase your risk of side effects, but in some cases, a combination of these two drugs may be the best treatment. If both drugs are prescribed for you, your doctor will usually change the dosage or determine how often you should take them.

Furazolidone
Iproniazid
Isocarboxazid
Linezolid
Methylene Blue
Metoclopramide
Moclobemide
Nialamide
Phenelzine
Procarbazine
Rasagiline
Selegiline
Tranylcypromine

Aclidinium
Alcaftadine
Amantadine
Ambenonium
Amdinocillin
Amiloride
Amineptine
Aminophylline
Amitriptyline
Amitriptylinoxide
Amoxapine
Amoxicillin
Ampicillin
Anisotropine
Antazoline
Aripiprazole
Astemizole
Atomoxetine
Atropine
Azatadine
Azelastine
Azlocillin
Bacampicillin
Belladonna Alkaloids
Benperidol
Bepotastine
Betamethasone
Bromodiphenhydramine
Bromperidol
Brompheniramine
Buclizine
Budesonide
Bupivacaine
Butriptyline
Butylscopolamine
Carbamazepine
Carbenicillin
Carbimazole
Carbinoxamine
Carvedilol
Chlorambucil
Chlorotrianisene
Chlorpheniramine
Chlorphenoxamine
Cimetidine
Cimetropium
Cinnarizine
Citalopram
Clemastine
Clemizole
Clidinium
Clobetasone
Clomipramine
Clopidogrel
Cloxacillin
Clozapine
Codeine
Conjugated Estrogens
Corticotropin
Cortisone
Cosyntropin
Cyclacillin
Cyclizine
Cyclosporine
Cyproheptadine
Dabrafenib
Danazol
Darifenacin
Deflazacort
Delavirdine
Demecarium
Desipramine
Desonide
Desvenlafaxine
Dexamethasone
Dexbrompheniramine
Dexchlorpheniramine
Dextromethorphan
Dibenzepin
Dicloxacillin
Dicyclomine
Dienestrol
Diethylstilbestrol
Dimenhydrinate
Diphenhydramine
Diphenylpyraline
Distigmine
Donepezil
Dopamine
Dothiepin
Doxepin
Doxorubicin
Doxorubicin Hydrochloride Liposome
Doxylamine
Droperidol
Duloxetine
Ebastine
Echothiophate
Edrophonium
Efavirenz
Eliglustat
Emedastine
Enflurane
Epinastine
Escitalopram
Esterified Estrogens
Estradiol
Estramustine
Estriol
Estrone
Estropipate
Ethinyl Estradiol
Famotidine
Fesoterodine
Flavoxate
Flecainide
Floxacillin
Fludrocortisone
Flunarizine
Flunisolide
Fluoxetine
Fluticasone
Fluvoxamine
Fosphenytoin
Galantamine
Glycopyrrolate
Guanidine
Haloperidol
Hetacillin
Homatropine
Hydrocortisone
Hydroxyzine
Hyoscyamine
Imipramine
Indalpine
Iobenguane I 123
Isoflurophate
Isoniazid
Isopropamide
Ketamine
Ketotifen
Levocabastine
Levodopa
Levomilnacipran
Lidocaine
Lindane
Lofepramine
Lopinavir
Loxapine
Mebeverine
Mebhydrolin
Meclizine
Memantine
Mepenzolate
Mestranol
Metformin
Methantheline
Methdilazine
Methenolone
Methicillin
Methixene
Methylphenidate
Methylprednisolone
Methyltestosterone
Metronidazole
Mexiletine
Mezlocillin
Milnacipran
Mirtazapine
Mizolastine
Nafcillin
Nalidixic Acid
Nandrolone
Nefazodone
Neostigmine
Niaprazine
Nortriptyline
Olopatadine
Ondansetron
Opipramol
Ospemifene
Oxacillin
Oxaliplatin
Oxandrolone
Oxatomide
Oxybutynin
Oxymetholone
Paramethasone
Paroxetine
Penicillin G
Penicillin V
Phenindamine
Pheniramine
Phenobarbital
Phenyltoloxamine
Phenytoin
Physostigmine
Pimozide
Pinaverium
Pindolol
Piperacillin
Pirenzepine
Pivampicillin
Pizotyline
Polyestradiol Phosphate
Prasugrel
Prednisolone
Prednisone
Procainamide
Procaine
Promestriene
Promethazine
Propafenone
Propantheline
Propicillin
Propiverine
Propizepine
Propranolol
Protriptyline
Pyrilamine
Quinestrol
Ranitidine
Regorafenib
Rimexolone
Risperidone
Ritonavir
Rivastigmine
Scopolamine
Sertraline
Sibutramine
Solifenacin
Sorafenib
Stanozolol
Sultamicillin
Tacrine
Terfenadine
Testosterone
Theophylline
Thioridazine
Thiotepa
Thonzylamine
Tibolone
Ticarcillin
Ticlopidine
Timiperone
Tiotropium
Tolterodine
Tramadol
Trimeprazine
Trimipramine
Tripelennamine
Triprolidine
Tropicamide
Trospium
Umeclidinium
Valethamate
Varenicline
Venlafaxine
Vortioxetine

St. John's Wort
Tipranavir
Zolpidem

Can food or alcohol interact with Bupropion?

Certain drugs should not be used with meals or when eating certain foods because drug interactions can occur. Consuming alcohol or tobacco with certain drugs can also cause interactions to occur. Discuss your use of drugs with food, alcohol, or tobacco with your health care provider.

Ethanol

What health conditions can interact with Bupropion?

Any other health conditions you have can affect the use of this drug. Some conditions that require you to tell your doctor before taking bupropion are:

Consuming alcohol and illegal drugs
There is a problem in blood circulation
Brain tumor or infection
Have had or are currently suffering from a seizure
Having trouble sleeping and taking sleeping pills
Stroke or worse, do not take this drug
Depression and mental illness such as hypomania, psychosis and bipolar disorder
Diabetes
Glaucoma
Have high or low blood pressure
Hyponatremia (low blood sugar level) and hypoxia (low blood oxygen level)
Liver and kidney disease

Bupropion overdose

What should I do in an emergency or overdose?

In case of an emergency or overdose, contact the local emergency services provider (112) or immediately to the nearest hospital emergency department.

What should I do if I miss a dose?

If you forget a dose of this medicine, take it as soon as possible. However, when it is nearing the time of the next dose, skip the missed dose and return to the usual dosing schedule. Remember, do not double the dose on the next schedule of consumption.